Navigation Links
Mount Sinai researchers discover why cocaine is so addictive
Date:10/18/2010

Mount Sinai researchers have discovered how cocaine corrupts the brain and becomes addictive. These findingsthe first to connect activation of specific neurons to alterations in cocaine rewardwere published in Science on October 15. The results may help researchers in developing new ways of treating those addicted to the drug.

Led by Mary Kay Lobo, PhD, Postdoctoral Fellow in the Department of Neuroscience at Mount Sinai School of Medicine and first author of the study, researchers found that the two main neurons (D1 and D2) in the nucleus accumbens region of the brain, an important part of the brain's reward center, exert opposite effects on cocaine reward. Activation of D1 neurons increases cocaine reward whereas activation of D2 neurons decreases cocaine reward.

"The data suggest a model whereby chronic exposure to cocaine results in an imbalance in activity in the two nucleus accumbens neurons: increased activity in D1 neurons combined with decreased activity in D2 neurons," said Dr. Lobo. "This further suggests that BDNF-TrkB signaling in D2 neurons mediates this decreased activity in D2 neurons."

The study was conducted using optogenetics, a technology to optically control neuronal activity in freely moving rodents.

Opposite cocaine reward similar to those found when activating each neuron is achieved by disrupting brain-derived neurotrophic factor, which is a protein in the brain known for its involvement in neuronal survival, learning, and memory and drug abuse signaling through its receptor TrkB in D1 or D2 neurons.

"This new information provides fundamentally novel insight into how cocaine corrupts the brains reward center, and in particular how cocaine can differentially effect two neuronal subtypes that are heterogeneously intermixed in the nucleus accumbens," said Eric Nestler, MD, PhD, Chair of Neuroscience, Nash Family Professor, and Director of The Friedman Brain Institute at Mount Sinai and co-author on the study. "We can use this information to potentially develop new therapies for cocaine addiction, possibly aimed at altering neuronal activity selectively in either neuronal subtype."


'/>"/>

Contact: Mount Sinai Press Office
newsnow@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. Mount Sinai researchers find new target to improve pain management
2. Small Amounts of Dark Chocolate May Guard Against Heart Failure
3. Mount Sinai pioneers new cardiac imaging device
4. Mount Sinai leads Consortium of Food Allergy Research with $29.9 million grant
5. The Marilyn B. Gula Mountains of Hope Foundation donates additional research funds to TGen
6. Chicago Father and Son Team to Climb Mount Kilimanjaro for ShelterBox
7. AAU Big Mountain Jam Basketball Tournament To Be Played On SnapSports Flooring
8. Mount Sinai researchers find structural basis for incidence of skin cancers in a genetic disorder
9. Women who consume large amounts of tea have increased risk of rheumatoid arthritis
10. Albeo Releases Six New Surface Mount LED Lighting Fixtures
11. Green Drinks NYC and Green Mountain Energy Company Present Summer Bash at Solar One
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/1/2017)... ... March 01, 2017 , ... ... announce the release of its 2017 update to Compass, the popular online ... physician advisors. , Suitable for standardizing both new-hire on-boarding and annual competency-validation, ...
(Date:3/1/2017)... ... , ... Expert on international living and leading a healthy lifestyle, Alina Reyzelman, ... & Go app is the ultimate strategic compass that helps users to achieve goals ... people to work smarter, not harder, that's why Time & Go app provides tools ...
(Date:3/1/2017)... ... ... is Comfort for the Soul”: a loving account of a very special dog, the ... soul-healing comfort provided by God’s presence in the face of deep sorrow. “There is ... dog-loving medical professional whose work takes her to remote areas in the American Northwest, ...
(Date:3/1/2017)... ... ... to the Law of God”: a message about the revelation of God to our dark ... God” is the creation of published author Brent Chrishon, a former sales professional who left ... dedicated their lives to spreading God’s word both in the United States and abroad. , ...
(Date:2/28/2017)... ... February 28, 2017 , ... Answering strong demand for its medical ... will open a branch office in the Soma neighborhood in San Francisco on March ... factors, FDA regulatory and software systems architecture subject matter experts. , Orthogonal serves a ...
Breaking Medicine News(10 mins):
(Date:3/1/2017)... Research and Markets has announced the addition of the ... report to their offering. ... The latest research Acute Myeloid Leukemia Drugs Price ... in the global Acute Myeloid Leukemia market. This research ... find out how the marketed products for Acute Myeloid Leukemia are ...
(Date:3/1/2017)... El mismo sistema se mostrará en el Congreso Europeo de Radiología (CER) ... ... The open MRI scanner - MROpen engineered and developed by Paramed in the ... Paramed ... primera en Gales. El escáner se localizará en el nuevo centro del European Scanning Centre ...
(Date:2/28/2017)... 2017 Persistence Market Research tables a ... market in a new publication named, "Dysphagia Management ... the name suggests, we have forecasted the global ... on the basis of the various market segments ... opportunities available to all the companies operating in ...
Breaking Medicine Technology: