Navigation Links
Mount Sinai researchers discover possible new target for sarcoma treatment and prevention
Date:5/23/2011

Researchers from Mount Sinai School of Medicine have discovered a protein signaling pathway that becomes hyperactivated in human sarcoma cells, suggesting that medications to inhibit this pathway may be effective in the treatment of human sarcomas. The research is published in the current issue of the journal Cancer Cell.

A team of researchers led by Stuart Aaronson, MD, Jack and Jane B. Aron Professor and Chairman of the Department of Oncological Sciences at Mount Sinai School of Medicine, compared normal human mesenchymal stem cells to human sarcoma cells and found that the sarcoma cells displayed hyperactive signaling along the Wnt pathway a complex network of proteins that interact with each other in a highly ordered manner to regulate numerous biological functions of various species.

The hyperactive Wnt signaling increased the growth of several subtypes of human sarcoma cells by increasing the expression of CDC25A, a gene previously shown to be deregulated in various types of cancer. Increased protein levels of CDC25A enhances the rate of cell proliferation, and cancer cells often exhibit very high CDC25A protein levels compared to normal cells.

"The prevalence of Wnt signaling hyperactivity in human sarcoma cells gives researchers a potential new target as they develop medications to target human sarcoma," said Dr. Aaronson.

"Since several cancer types show increased CDC25A levels, it is regarded as a good target to generate therapeutic agents to dampen its functions and thus will be an important candidate in future drug development," said Sapna Vijayakumar, PhD, Instructor of Oncological Sciences, Mount Sinai School of Medicine, who was the first author of the study.

Normal Wnt functioning is critical for maintaining tissue homeostasis. Hyperactive (deregulated) Wnt signaling is reported to be one of the early causes of colon cancer, and it is also implicated in several other cancer types.


'/>"/>
Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Amount of HIV in Genital Fluid Linked to Transmission
2. Mount Sinai finds promising clue to mechanism behind gene mutation that causes Parkinsons disease
3. Trace Amounts of Radiation Reach California; No Health Risk, Experts Say
4. Mount Sinai researcher finds unexpected temperature sensation for a light detector
5. Number of Mountain Bike Injuries Dropping
6. Long- and short-sleeved physician workwear receive same amount of bacterial and MRSA contamination
7. New national study finds mountain bike-related injuries down 56 percent
8. FDA Lowers Amount of Acetaminophen Allowed in Prescription Painkillers
9. Mount Sinai develops first screening tool for war veterans to assess traumatic brain injury
10. Mount Sinai researchers make major breakthrough in melanoma research
11. Mount Sinai first in US to implant aortic valve prosthesis to treat severe aortic stenosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... 2015 "I wanted to live ... a healthful juice that contained essential vitamins, minerals ... "It increases my energy, improves skin elasticity and ... developed Tapp's Juice to contain fruits, vegetables and ... physical and mental fatigue. It features a great ...
(Date:4/18/2015)... 18, 2015 Insuranceautoquote.info has released a ... auto insurance quotes . , Clients can review ... website. The online environment provides important advantages for clients ... , Drivers who do not have coverage for their ... any season, day or hour. Many agencies offer important ...
(Date:4/18/2015)... Lower-auto-insurance.com has released a new blog post explaining how ... , Drivers can find accurate information about various ... brokerage website can help drivers compare the newest and ... The whole process is designed to be convenient, free ... insurance quotes is advantageous because it allows clients to ...
(Date:4/18/2015)... 18, 2015 Thousand of DePuy Pinnacle ... of individuals who were allegedly harmed by a metal-on-metal ... forward in the U.S. District Court, Northern District of ... Court has amended an earlier Case Management Order to ... things, the new amendment permits the claims of up ...
(Date:4/18/2015)... More than 2000 styles of newly designed prom dresses ... store carrying celebrity inspired special occasion dresses. With the ... dresses for their prom. For those who are still ... would be an ideal choice. , "We have ... by the most loved styles seen at this years ...
Breaking Medicine News(10 mins):Health News:Clients Can Review Car Insurance Quotes Online To Find Low Cost Offers! 2Health News:Auto Insurance Quotes Can Provide Accurate Results! 2Health News:DePuy Pinnacle Hip Lawsuits: Federal Litigation Amends Case Management Order to Allow for Joinder of Unrelated Claims 2Health News:DePuy Pinnacle Hip Lawsuits: Federal Litigation Amends Case Management Order to Allow for Joinder of Unrelated Claims 3Health News:Prom Dresses 2015 on Sale at TheCelebrityDresses.com 2
... , ... Pacific Dental Services (PDS) participated in the ... awareness about the importance of oral health. Forty PDS-affiliated offices – ... schools, churches and homeless shelters – provided a day of free ...
... Utah study emphasizes need for unused pills to be tossed out, ... people who illegally use or abuse opioid painkillers such as Oxycontin ... had a prescription, a new report shows. , In the study, ... almost 2 percent of respondents said they had taken an opioid ...
... wartime camaraderie extend far beyond the battlefield, a new UCLA ... Veterans who served in military units characterized by a strong ... die of a stroke or heart condition than veterans from ... "On the battlefield, you,d expect your buddy to have ...
... ... that provide customized allergy information to its users. MyPollen automatically provides users with allergy ... track of their allergy symptoms. , ... (Vocus) February 18, 2010 -- Pollen.com , the most visited ...
... ... Physicians Health Choice exceeded its Annual Enrollment Period sales goals. , ... San Antonio, TX (Vocus) February 18, ... for their affordable health plans and pro-active approach to wellness — is celebrating a ...
... , ... Recently, the Facility of the Year Awards (FOYA) were announced by the program’s ... projects that incorporate innovative technologies into their operations to yield top quality products. ... facilities. , ...
Cached Medicine News:Health News:Pacific Dental Services Gives Smiles to More Than 400 Children 2Health News:Pacific Dental Services Gives Smiles to More Than 400 Children 3Health News:Oxycontin Abusers Often Rely on 'Leftover' Meds From Friends 2Health News:Oxycontin Abusers Often Rely on 'Leftover' Meds From Friends 3Health News:Battlefield camaraderie yields long-term dividends for veterans, study finds 2Health News:Battlefield camaraderie yields long-term dividends for veterans, study finds 3Health News:Battlefield camaraderie yields long-term dividends for veterans, study finds 4Health News:Pollen.com Launches Features to Customize Allergy Information - ,Top Allergy Web Site Provides ZIP-specific Allergy Information and Diary to Track Symptoms 2Health News:Pollen.com Launches Features to Customize Allergy Information - ,Top Allergy Web Site Provides ZIP-specific Allergy Information and Diary to Track Symptoms 3Health News:Pollen.com Launches Features to Customize Allergy Information - ,Top Allergy Web Site Provides ZIP-specific Allergy Information and Diary to Track Symptoms 4Health News:Top-Rated Medicare Advantage Plan Reaches 27,000-Member Milestone 2Health News:Awards Strengthen Stonhard's Reputation for High-Performing Floors in the World's Most Prominent Pharmaceutical Facilities 2
(Date:4/17/2015)... , Apr. 17, 2015 Steven Rash ... ALGA ), and its operating subsidiary American Seed & ... exclusive presentation to investors yesterday in New York City.  ... The American Seed & Oil Company has ... Hippie Butter Hemp Seed Foods , the ...
(Date:4/17/2015)... Apr. 16, 2015 Research and Markets ... "Corporate Reputation of Pharma in 2014 - a ... report to their offering. This independent study, ... patient groups with an interest in diabetes on the ... the pharma industry as a whole) in 2014. The ...
(Date:4/17/2015)... Research and Markets ( http://www.researchandmarkets.com/research/kh5kqg/the_corporate ... "The Corporate Reputation of Pharma - The Patient ... report to their offering. The Corporate ... in its fourth edition. This report contains the ... each annual Corporate Reputation report, the author surveys ...
Breaking Medicine Technology:American Seed & Oil Company Benchmarks its Consumer Product Development Strategy Against Proctor & Gamble 2American Seed & Oil Company Benchmarks its Consumer Product Development Strategy Against Proctor & Gamble 3Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 2Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 3Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 4Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 5The Corporate Reputation of Pharma - The Global Patient Perspective in 2014 2
... Switzerland, April 3, 2007 (PRIME NEWSWIRE) -- ... and,pharmacokinetic profiles of Basilea's (SWX:BSLN) two late-stage,drug ... ceftobiprole, the first anti-MRSA broad-spectrum,cephalosporin in late-stage ... the treatment of invasive fungal infections,yielded further ...
... 4, 2007 - CytRx Corporation,(NASDAQ:CYTR) today announced ... that CytRx's lead drug candidate,arimoclomol significantly accelerated ... an experimental rat model of stroke, even ... hours after stroke was,induced. These data confirm ...
Cached Medicine Technology:Scientific Results Presented At ECCMID Demonstrate Well-,Differentiated Profile of Basilea's Two Phase III Anti- infective,Compounds 2Scientific Results Presented At ECCMID Demonstrate Well-,Differentiated Profile of Basilea's Two Phase III Anti- infective,Compounds 3Scientific Results Presented At ECCMID Demonstrate Well-,Differentiated Profile of Basilea's Two Phase III Anti- infective,Compounds 4Scientific Results Presented At ECCMID Demonstrate Well-,Differentiated Profile of Basilea's Two Phase III Anti- infective,Compounds 5Scientific Results Presented At ECCMID Demonstrate Well-,Differentiated Profile of Basilea's Two Phase III Anti- infective,Compounds 6Scientific Results Presented At ECCMID Demonstrate Well-,Differentiated Profile of Basilea's Two Phase III Anti- infective,Compounds 7CytRx Announces Positive Results of Arimoclomol in Preclinical,Stroke Recovery Studies 2CytRx Announces Positive Results of Arimoclomol in Preclinical,Stroke Recovery Studies 3CytRx Announces Positive Results of Arimoclomol in Preclinical,Stroke Recovery Studies 4CytRx Announces Positive Results of Arimoclomol in Preclinical,Stroke Recovery Studies 5
XL STABI Hydrophilic Acrylic Lens....
XL OCTO Hydrophilic Acrylic Lens....
One piece multifocal acrylic intraocular lens....
MemoryLens Prefolded Acrylic Lens....
Medicine Products: