Navigation Links
Mount Sinai researchers discover origin of immune cells in the brain
Date:10/22/2010

Mount Sinai researchers have discovered that microglia, the immune cells that reside in the brain, have a unique origin and are formed shortly after conception. It was previously thought that microglia originated at the same time as macrophages, which are other immune cells that are thought to develop at birth. This groundbreaking discovery has the potential to lead to future treatments of degenerative brain diseases such as Alzheimer's and autoimmune diseases such as multiple sclerosis. The study is published online October 21 in Science Express.

Microglia are thought to play an important role in the development of many brain diseases, and that defective microglia could lead to the release of inflammatory molecules, which could participate in the development of degenerative brain diseases.

"This really is a startling discovery," said Miriam Merad, MD, PhD, Associate Professor of Gene and Cell Medicine at Mount Sinai School of Medicine and Principal Investigator of the study. "We've shown that the precursor cells develop into microglia only during a short period after conception. Now that we know that microglia originate in early embryos, theoretically we should be able to generate microglia from embryonic stem cells to treat brain diseases caused by defective microglia. This is a very good example of why scientists need to be able to conduct research with embryonic stem cells."

For the first part of the study, researchers transplanted blood cell precursors, which are precursors for all macrophages, from one newborn mouse to another. The transplanted cells could not be differentiated in the recipient animal. These results suggest that microglia originated prior to birth during embryonic life.

Next, researchers used a mouse model that expresses fluorescent biosensors in blood precursors to determine when, during embryonic age, precursors develop into microglia. Once activated the fluorescence does not go away and
'/>"/>

Contact: Mount Sinai Press Office
newsnow@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
2. Childhood obesity: Its not the amount of TV, its the number of junk food commercials
3. New York and Connecticut Drug Rehab Center Mountainside Weighs In on Latest White House Budget
4. Mountain Home 'Doing the Right Thing Really is the Best Business Approach'
5. Dominos Pizza(R) Raises Record Amount for St. Jude Childrens Research Hospital
6. Excitement Surrounding "Unveil Your Pink" Mounts!
7. Connecticut Governor Jodi Rell Honors Mountainside Addiction Treatment Center for its Twelve Years of Operating in Connecticut
8. Healthcare Trust of America, Inc. Executes Agreement to Acquire an Approximately 60,800 Square Foot Medical Office Building in Mount Pleasant, South Carolina
9. Mount Sinai researchers are the first to identify heart abnormalities in World Trade Center workers
10. Rutgers University Offers Fundamentals of Finance and Accounting Workshop at Mount Laurel, New Jersey Location Aimed at Non-Financial Managers
11. BOTOX Cosmetic & Wrinkle Filler Specialist Hosts Advanced Training Event at Ageless Beauty in Mountain Home, ID
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... Columbus, Ohio (PRWEB) , ... August 28, 2015 ... ... Saturday’s Imagine No Malaria Day at the Zoo to celebrate children helping children, ... people and their congregations throughout West Ohio have contributed to the United Methodist ...
(Date:8/28/2015)... ... , ... For Dallas, the time is nearing for the annual Heart Walk, ... , The American Heart Association hosts their well-known Heart Walk to raise money in ... difference can be made. Walkers can participate in the cause and someone can also ...
(Date:8/28/2015)... ... August 28, 2015 , ... On May 30th, 2015, Best Drug Rehabilitation, ... the “Music With A Mission” benefit concert in Mendon, IL. Held in the Show ... money to support music education programs in the underfunded local school districts of Mendon ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... documenting and diagramming network and data center assets and audio-video devices, recently released ... Cisco Nexus 5000 Series, HP ProLiant Gen9, EMC VNX Series , Super Micro ...
(Date:8/28/2015)... Utah (PRWEB) , ... August 28, 2015 , ... ... awarded a three-year accreditation for its adolescent residential, counseling, day treatment and intensive ... that it meets international standards for quality and its pursuit of excellence. As ...
Breaking Medicine News(10 mins):Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 2Health News:Saturday’s United Methodist Event at Columbus Zoo Celebrates Imagine No Malaria 3Health News:North Central Surgical Center’s Subsidiary Participates in Walk 2Health News:New Video Released on "Music With A Mission" Benefit Concert Headlining Artist Cadillac Three & Best Drug Rehabilitation 2Health News:Altima Updates NetZoom™ Visio® Stencil Library for Cisco, HP, and EMC Devices 2Health News:Altima Updates NetZoom™ Visio® Stencil Library for Cisco, HP, and EMC Devices 3Health News:West Ridge Academy Awarded CARF Three-Year Accrediation 2
... for tuberculosis has revealed that nearly 40% of the doctors ... levels// in those who work in TB clinics. The research ... is a growing problem worldwide. Russia is one country where ... the world's population are infected with the bacterium that causes ...
... breast cancer therapy drug tamoxifen, to another one exemestane//, could ... their findings in the online version of The Lancet, researchers ... and team, stood for changing treatments tracks to exemestane after ... reduced deaths by 17 percent. ,Their findings stem ...
... drug that aids patients who suffer from persistent iron overload ... ,Patients suffering from a rare genetic condition or ... transfusions. Generally these people are given a painful infusion at ... hours. ,But the new drug Exjade is an ...
... Carnegie Institution's Department of Plant Biology have discovered ... regulation—neighboring pore-like structures at the cell's surface physically ... nutrient, nitrogen. It is the first time scientists ... is essential to this regulation. Since plants, animals, ...
... new technique that uses ozone to preserve grapes could help ... reports Jennifer Rohn in Chemistry & Industry, the magazine of ... wine-making process to produce healthier wines without the added sulphites ... ,Mass-marketed grapes can remain in storage for months ...
... research currently underway brings hope of dramatic advances ... review//. The review reveals that new approaches in ... chemotherapy, and research on breast cancer vaccines may ... physician treating breast cancer patients. These new tools ...
Cached Medicine News:Health News:New Drug Therapy for Breast Cancer Offers Hope 2Health News:New Mechanism for Nutrient Uptake Discovered 2Health News:New Mechanism for Nutrient Uptake Discovered 3Health News:Grape Expectations for Healthier Wine 2Health News:Emerging Research Heralds New Era of Breast Cancer Management 2
(Date:8/28/2015)... , Aug. 28, 2015 ... the addition of the "Investigation Report on ... their offering. Developed by Novo Nordisk, ... is an important drug for the treatment of ... a fast- acting insulin analog, starts working fast ...
(Date:8/28/2015)... -- IP Shakti, LLC, today announced that it has changed its ... Logo - http://photos.prnewswire.com/prnh/20150827/261551LOGO ... signifies our transformation into a company focused on patent claim ... claim validity." ... platform, the Company commenced a corporate re-branding initiative in order ...
(Date:8/28/2015)... England and PITTSBURGH ... MYL ) today announced that its shareholders ... plc (NYSE: PRGO ; TASE) and the ... shareholders at an extraordinary general meeting of shareholders ... the votes cast at the extraordinary general meeting. ...
Breaking Medicine Technology:China Insulin Aspart Market Report 2010-2019 - Developed by Novo Nordisk 2IP Shakti, LLC Changes Company Name to Prediqtus, LLC 2Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 2Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 3Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 4Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 5Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 6Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 7Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 8Mylan Shareholders Overwhelmingly Approve Proposed Acquisition of Perrigo 9
... Reportlinker.com announces that a new market research ... Global Pico Projector By Application, Technology ... http://www.reportlinker.com/p0304770/Global-Pico-Projector-By-Application-Technology--Products-Market-2010-2014.html REPORT ... revolutionize the global projector market by making projectors ...
... Sept. 28 Today Governor Deval Patrick and Massachusetts ... state and local officials, Organogenesis, Inc. CEO Geoff MacKay ... new headquarters building at 85 Dan Road in Canton. ... announcing that its Apligraf®  living cell based product has ...
Cached Medicine Technology:Reportlinker Adds Global Pico Projector By Application, Technology & Products Market (2010-2014) 2Reportlinker Adds Global Pico Projector By Application, Technology & Products Market (2010-2014) 3Reportlinker Adds Global Pico Projector By Application, Technology & Products Market (2010-2014) 4Reportlinker Adds Global Pico Projector By Application, Technology & Products Market (2010-2014) 5Reportlinker Adds Global Pico Projector By Application, Technology & Products Market (2010-2014) 6Governor Patrick, Life Sciences Center Celebrate Organogenesis' New Headquarters 2Governor Patrick, Life Sciences Center Celebrate Organogenesis' New Headquarters 3Governor Patrick, Life Sciences Center Celebrate Organogenesis' New Headquarters 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: