Navigation Links
Mount Sinai researchers discover novel mechanisms that might causally link type-2 diabetes to Alzheimer's disease
Date:4/10/2009

of the clinical disease and positively correlates with brain accumulation of β-amyloid, an abnormal protein highly linked to Alzheimer' disease dementia and brain degeneration. This evidence is of high interest to the field and suggests, for the first time, a strong relationship between decreased content of a gene responsible for type-2 diabetes in Alzheimer's disease dementia cases, says Dr. Pasinetti.

"Of considerable interest," continues Dr. Pasinetti, "is the evidence found in further mechanistic studies in our laboratory, indicating that promoting PGC-1 content in brain cells, using a transgenic mouse model of Alzheimer's disease, attenuates hyperglycemic-mediated production of β-amyloid, highly linked to Alzheimer' disease dementia. These findings are very exciting, and for the first time tentatively link type-2 diabetic metabolic defects to increasing dementia mediated by β-amyloid production."

The discovery in Dr. Pasinetti's laboratory has staggering societal implications: there are currently more than 5 million Americans affected by Alzheimer's disease dementia, and the disease incidence is expected to skyrocket in the three decades as the population ages. The question now is how we can translate this evidence into the development of novel approaches for disease prevention and treatment.

Dr. Pasinetti and his colleagues are optimistic that if they find that PGC-1α can be manipulated pharmacologically, these studies will provide important insights to be used in the formulation of novel treatments and possible preventative strategies in Alzheimer's disease.


'/>"/>

Contact: Mount Sinai Press Office
newsnow@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Obama Notre Dame Abortion Tension Mounts: Good Friday Protests at White House, and in Dallas, Los Angeles, and Fort Wayne
2. According to Frost & Sullivan, Mounting Clinical Evidence Underlines Benefits of Bone Growth and Spinal Fusion Stimulators
3. Mount Sinai first in US to implant FDA-cleared ring for mitral valve repair
4. Drug Rehab Mountainside Treatment Center is an Effective and Quality Option for Those Seeking Drug Treatment - Located Close to NY MA
5. U.S. Preventive Medicine(R), The Mount Sinai Medical Center Sign Affiliation Agreement to Jointly Deliver Preventive Medicine Services
6. Local Infertility Specialist, Dr. Rachel Bennett, Westchester Reproductive Medicine, Opens New Office in Mount Kisco
7. Astronauts on International Space Station lose alarming amounts of hipbone strength
8. Peanut Butter Product Recalls Mount
9. Identity Theft on Agenda at Rocky Mountain Dental Conference
10. Grubb & Ellis Healthcare REIT Acquires Mountain Plains Portfolio in Texas
11. White Mountains Re Announces Management Changes -- Chokel to Retire and Remain Risk Advisor at WTM
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2015)... Carinsurancequotesinfo.com has released a new blog post that explains ... for flatbed trucks. , Flatbed trucks are used ... are mainly used for commercial purposes and thus require ... that by comparing multiple offers, drivers can find low ... , It is now possible to compare free online ...
(Date:4/25/2015)... Gardant Management Solutions will lead sessions ... and sales and marketing at the LeadingAge Illinois ... held from April 29 through May 1 in ... eldercare association in Illinois. The statewide association represents ... including senior housing, assisted living and supportive living ...
(Date:4/25/2015)... On Friday, April 17, Interstate Batteries was ... Implementation Award. This award is given to the ... RFID technology to improve its manufacturing, supply chain or ... demonstrates how RFID is delivering real value to shareholders. ... 2015 in San Diego, the RFID industries annual trade ...
(Date:4/24/2015)... Multi Customer Discount , Rules: This ... http://www.zeitersseptics.com/multi-customer-discount.html ) of 1000-1500 gallons in Zeiter's Septics service ... does not include any Dig fees, or any other ... If someone is part of this group event and ... 2500 gallons or more, the cost would be $300.00. ...
(Date:4/24/2015)... Houston, TX (PRWEB) April 24, 2015 The ... Dan Long, after their great success of the Xtreme Fat ... the industry. The fat loss blueprint that claims to ... caught the attention of HealthyandFitZone.com's Stan Stevenson, prompting an investigative ... shows that the creators spent years researching and experimenting ...
Breaking Medicine News(10 mins):Health News:Auto Insurance Quotes for Flatbed Trucks Available Online! 2Health News:Gardant Management Solutions Staff Shares Operational Expertise 2Health News:Seeonic’s Industry Leading Technology Powers Interstate Batteries to Winning Award 2Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 2Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 3Health News:Fastest Fat Loss Week Ever Review Revealed on Healthy & Fit Zone 2
... executive, has warned that acute hospitals and Action and Emergency (A&E) ... health services deficit of ?512million. He added that ... may be combined in fewer units. ,He pointed out ... have to be maintained along with ...
... Tshwane University of Technology (TUT) have recommended shopping till ... not revenge on your husband or even your bank ... ,Department of sport and physical rehabilitation sciences ... the group of 40 students stumbled upon this finding ...
... has claimed 49 lives and affected 20,000 people in West ... Das told the West Bengal Assembly today. // ... as those of malignant malaria, Das said during mention hour., ... he said that it was far from adequate. Besides, there ...
... (INSH) ASHVINI located in Mumbai has been named the best ... ,Defence Minister Pranab Mukherjee awarded the Running trophy and a ... the hospital, Rear Admiral V K Saxena here today., ... functioning hospital among the Command Hospitals of the Indian Army ...
... moghul and UN Messenger for Peace, Vijay Amritraj, has ... India among HIV/AIDS victims. // ,The UN ... HIV/AIDS in India and only a fraction is getting ... medicines for the disease., ,Launching the `Amritraj Foundation' ...
... levels of benzene in two diet drinks, which has ... market. , ,The two drinks that have been ... Rose's Diabetic Squash Concentrate. Stricter guidelines have been enabled ... benzene formation in the drinks., ,Benzene, a ...
Cached Medicine News:
(Date:4/24/2015)... LONDON , April 24, 2015 ... leader in the development of biosimilar therapies, spoke about ... today at the European Generics Association (EGA) annual European ... The company also announced the publication of ... paramount to achieving the full promise of biosimilars." ...
(Date:4/23/2015)... -- Edwards Lifesciences Corporation (NYSE: EW ), the global ... monitoring, today reported net income for the quarter ended ... share.  Net income for the same period a year ... and non-GAAP net income was $82.1 million, or $0.76 ... quarter ended March 31, 2015 increased 13.0 percent to $590.3 ...
(Date:4/23/2015)...  Jazz Pharmaceuticals plc (Nasdaq: JAZZ ) today ... financial results on Thursday, May 7, 2015, after the ... a live audio webcast immediately following the announcement at ... 2015 financial results and provide a business and financial ... audio webcast via the Investors & Media section of ...
Breaking Medicine Technology:Hospira Leadership Presents at Preeminent European Biosimilars Forum, Announces New White Paper on Extrapolation 2Hospira Leadership Presents at Preeminent European Biosimilars Forum, Announces New White Paper on Extrapolation 3Hospira Leadership Presents at Preeminent European Biosimilars Forum, Announces New White Paper on Extrapolation 4Hospira Leadership Presents at Preeminent European Biosimilars Forum, Announces New White Paper on Extrapolation 5Hospira Leadership Presents at Preeminent European Biosimilars Forum, Announces New White Paper on Extrapolation 6Hospira Leadership Presents at Preeminent European Biosimilars Forum, Announces New White Paper on Extrapolation 7Edwards Lifesciences Reports First Quarter Results 2Edwards Lifesciences Reports First Quarter Results 3Edwards Lifesciences Reports First Quarter Results 4Edwards Lifesciences Reports First Quarter Results 5Edwards Lifesciences Reports First Quarter Results 6Edwards Lifesciences Reports First Quarter Results 7Edwards Lifesciences Reports First Quarter Results 8Edwards Lifesciences Reports First Quarter Results 9Edwards Lifesciences Reports First Quarter Results 10Edwards Lifesciences Reports First Quarter Results 11Edwards Lifesciences Reports First Quarter Results 12Edwards Lifesciences Reports First Quarter Results 13Edwards Lifesciences Reports First Quarter Results 14Edwards Lifesciences Reports First Quarter Results 15Edwards Lifesciences Reports First Quarter Results 16Jazz Pharmaceuticals to Report 2015 First Quarter Financial Results on May 7, 2015 2
... June 4 After three long years of ... of Phoebe Sumter Medical Center welcomed the arrival of a ... Siemens Healthcare. The new MRI scanner premiered today at the ... destroyed the hospital in 2007. State and local political dignitaries ...
... Mylan Inc. (Nasdaq: MYL ) today announced that its subsidiary ... and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) ... version of Pfizer,s Neurontin® Tablets for the treatment of postherpetic neuralgia, ... Pharmaceuticals Inc. , , ...
Cached Medicine Technology:Siemens Donates MRI Scanner to Help Rebuild Phoebe Sumter Medical Center 2Siemens Donates MRI Scanner to Help Rebuild Phoebe Sumter Medical Center 3Mylan Receives Approval for Generic Version of Neurontin® Tablets 2
The Linvatec 3mm and 5mm Universal Light Guides are autoclavable. They offer flexibility, superior light transmission, and universal fittings in a lightweight package....
ACMI™ offers an assortment of fiberoptic light guides, high transmission autoclavable fiberoptic light guides, and light guide adapters to connect our scopes to other manufacturers' light sourc...
... MicroDigital IP 6.2 Series Image Processing Video ... for all surgical specialties. This camera incorporates ... such as brightness, enhancement, gain, and white ... Multiple-range image enhancement and adjustable picture level ...
... electrokinetic lithotripter particularly for lower ureteral ... in application to all kinds of ... salivary gland stones. It may also ... energy transmitted by direct contact between ...
Medicine Products: