Navigation Links
Mount Sinai researchers discover new target for vaccine development in abundant immune cells
Date:7/24/2012

important because we discovered a completely new function in an immune cell that has been studied since immunology research began," said Dr. Cerutti. "The interactivity of the neutrophils in the innate immune system with the B-cells of the more sophisticated adaptive immune system shows that neutrophils operate at a much higher level than previously thought and play a very critical role in mounting a robust response to infection."

Dr. Cerutti's team also evaluated the spleens of people with a condition called neutropenia, which is characterized by a shortage in neutrophils and a compromised immune system, and found that the marginal zones in the spleens of these patients had fewer B-cells and antibodies. This demonstrates the necessity of having neutrophils interact with marginal zone B-cells to generate an innate layer of antibody defense. The fact that the research team found an abundance of neutrophils and marginal zone B-cells in the spleens from healthy individuals, but not neutropenic patients, indicates that these cells are primed and prepared to launch multi-level antibody production in healthy humans, even in the absence of a pathogen.

"Since neutrophils boost and reprogram B-cells to strengthen the immune system regardless of whether there is an infection, we may be able to harness them in vaccine development to enhance immune protection," said Dr. Cerutti. "This has significant promise in vaccinating against blood-borne infections, as B-cells are the first line of defense to antigens in the circulatory system. If we can improve vaccines with neutrophil-activating agents, we may have a chance to boost B-cell antibody production, and improve immune protection."

With this new knowledge, Dr. Cerutti and his collaborator Meimei Shan, PhD, from Mount Sinai, are evaluating neutrophil activation and B-cell antibody production in rhesus monkeys vaccinated against Simian Immunodeficiency Virus (SIV), or HIV as it occurs in monkeys, using
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Is acetazolamide effective and safe for preventing acute mountain sickness?
2. Be Present Welcomes Wanderlust Festival to Copper Mountain, Colorado
3. Mount Sinai finds common factors in autism spectrum disorders, schizophrenia, and bipolar disorder
4. Americans Already Consuming the Right Amount of Salt
5. Mount Sinai researcher finds timing of ADHD medication affect academic progress
6. Limited amounts of alcohol during pregnancy do not harm children
7. Mount Sinai is first in New York state to perform new Alzheimers imaging test in clinical setting
8. Mount Sinai researchers develop a multi-target approach to treating tumors
9. Mount Sinai presents treatment trends, vaccine research, prognosis data at ASCO
10. Great recession reflux amounts to more hunger among seniors
11. David H. Koch donates $10 million to Mount Sinais Jaffe Food Allergy Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Biology and Medicine a multidisciplinary research team ... in the Institute of Genomic Biology (IGB) on ... describe their recent work on subcellular redox homeostasis. ... functions including energy metabolism, signaling, and transcriptional processes. ... cellular behavior, redox status has been recognized as ...
(Date:4/17/2014)... a review published in the April issue of ... Feinstein Institute for Medical Research, says it,s time to ... approach to treating sepsis, which kills millions worldwide ... occurs when molecules released into the bloodstream to fight ... Inflammation is necessary for maintaining good health without ...
(Date:4/17/2014)... NY, April 17, 2014U.S. military personnel who served ... impact" concussive traumatic brain injury (TBI) were compared ... for other medical reasons. Differences in measures of ... 6-12 months after injury are reported in an ... peer-reviewed journal from Mary Ann Liebert, Inc., publishers. ...
(Date:4/17/2014)... YORK, NY (April 16, 2014) The cause of ... a new study proposes that neurons may be mistaken ... immune system, similar to the way autoimmune diseases like ... the body,s cells. The study was published April 16, ... a new, and likely controversial, idea in Parkinson,s disease; ...
(Date:4/17/2014)... School of Medicine (BUSM) have discovered that the ... experimental model. The findings, reported in the ... may lead to more effective treatments for alcoholism. ... the leading causes of illness and death in ... by limiting the productivity of workers and necessitating ...
Breaking Medicine News(10 mins):Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:Is Parkinson's an autoimmune disease? 2Health News:BUSM researchers find anti-seizure drug may reduce alcohol consumption 2
... more than 10% of preschoolers in the U.S. are ... toddlers are urgently needed to stop the progression of ... in Childhood Obesity , a peer-reviewed journal from ... free online ahead of print on the Childhood ...
... Deutsches rzteblatt International is focusing on medical ... of Statutory Health Insurance Physicians, and his coauthors ... future professional lives as doctors (Dtsch Arztebl Int ... Esther Ziemann and Jrg-Wilhelm Oestmann, who studied doctors, ...
... limits sexual activity is common among older patients with ... "We compared measures of well-being, depression and sexual function ... both of which are associated with dypnea during exertion," ... Hospital in Denmark. "A significantly higher percentage of COPD ...
... of heart disease already have heart damage, according to new ... Failure Congress 2012 , 19-22 May, in Belgrade, Serbia. The ... Association of the European Society of Cardiology., Obesity ... has shown that obese adults have structural and functional changes ...
... AND BOSTON (May 20, 2012) -- A collaborative expedition into ... subtype of the disease, one that appears to account for ... Weill Cornell Medical College, the Broad Institute of MIT and ... published online May 20 by the journal Nature Genetics ...
... (HealthDay News) -- ,Exposure to air pollution while in ... with asthma, a new study finds. Researchers conducted ... of 6 and 15 in Fresno, Calif., and used ... mothers, exposure to air pollution during pregnancy. The ...
Cached Medicine News:Health News:A systems approach to preventing obesity in early life 2Health News:University studies and career expectations of medical students 2Health News:Troublesome dyspnea during sexual activity is common in COPD patients 2Health News:Obese adolescents have heart damage 2Health News:Scientists discover distinct molecular subtype of prostate cancer 2Health News:Scientists discover distinct molecular subtype of prostate cancer 3Health News:Scientists discover distinct molecular subtype of prostate cancer 4
(Date:1/14/2014)... , Jan. 14, 2014   NuAire , a manufacturer of ergonomically ... with Hitachi Koki of Japan ... North America . NuAire will utilize its network of ... Canada to offer assistance in application use, ...
(Date:1/14/2014)... Oligomerix, Inc. , a privately held company pioneering the ... and related neurodegenerative disorders, announced today the relocation of ... as of January 15, 2014 and expanded lease ... College. Oligomerix, which is focused on the ...
(Date:1/14/2014)...   Evidera , a leading provider of evidence-based solutions ... Drug Evaluation and Research (CDER), U.S. Food and Drug ... for a patient-reported outcome (PRO) measure in drug development: ... [EXACT] for Measurement of Symptoms of Acute Bacterial Exacerbation ...
Breaking Medicine Technology:NuAire announces sales and service of Hitachi Koki centrifuges in North America 2Oligomerix Relocates Corporate Headquarters and Secures Additional Laboratory Space from New York Medical College 2Evidera Announces Release of FDA Draft Guidance on Use of the "EXACT" to Measure Symptoms of COPD Exacerbations 2Evidera Announces Release of FDA Draft Guidance on Use of the "EXACT" to Measure Symptoms of COPD Exacerbations 3Evidera Announces Release of FDA Draft Guidance on Use of the "EXACT" to Measure Symptoms of COPD Exacerbations 4
FlexiSlip™ Plastic coated malleable metal core. Single use, Sterile, Latex Free. Soft distal tip flexes to reduce risk of trauma to patient. Malleable metal core is easy to shape. Low friction ...
Surgical Stainless Steel Child Stylette....
Surgical Stainless Steel Adult 16.5....
Ultra-Slip™ endotracheal tube guide for single-patient use only., ,Caution: Not MRI Compatible....
Medicine Products: