Navigation Links
Mount Sinai researchers discover new target for vaccine development in abundant immune cells
Date:7/24/2012

White blood cells called neutrophils, which are the first line of defense against infection, play an unexpected role by boosting antibody production, according to research led by Mount Sinai School of Medicine. The findings suggest neutrophils have multiple roles within the immune system and function at levels previously unknown to the scientific community. The research, published in Nature Immunology, provides groundbreaking insight into possible new approaches in vaccine development for blood-borne infections and HIV.

Neutrophils are part of the so-called innate immune systemthe immune system encoded at birth that remains unchangedand are at the front lines defending against infection and inflammation. The research was led by Andrea Cerutti, MD, Professor of Medicine at Mount Sinai School of Medicine, and included an international team of investigators that also involved Irene Puga, PhD, of IMIM-Hospital del Mar in Barcelona, Spain, and Montserrat Cols, PhD, of Mount Sinai.

Researchers evaluated healthy human tissues key to the immune system to assess the abundance of neutrophils in the lymph nodes, tonsils, lymphoid tissue in the intestine, and the spleen. They found very few neutrophils in all areas but onethe region of the spleen called the marginal zone. The spleen is an organ whose primary role is as a filtration system for agents that cause infection and inflammation in the body. Looking more closely at these cells, they found that their role spanned beyond the innate immune system.

According to the study, neutrophils in the marginal zone express two molecules called BAFF and APRIL, which then activate immune cells called B-cells in the adaptive immune system, which is more sophisticated and dynamic than the innate immune system. Neutrophils signal BAFF and APRIL to reprogram B-cells to create different classes of antibodies, allowing the immune system to mount a more potent antibody response.

"Our study is
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Is acetazolamide effective and safe for preventing acute mountain sickness?
2. Be Present Welcomes Wanderlust Festival to Copper Mountain, Colorado
3. Mount Sinai finds common factors in autism spectrum disorders, schizophrenia, and bipolar disorder
4. Americans Already Consuming the Right Amount of Salt
5. Mount Sinai researcher finds timing of ADHD medication affect academic progress
6. Limited amounts of alcohol during pregnancy do not harm children
7. Mount Sinai is first in New York state to perform new Alzheimers imaging test in clinical setting
8. Mount Sinai researchers develop a multi-target approach to treating tumors
9. Mount Sinai presents treatment trends, vaccine research, prognosis data at ASCO
10. Great recession reflux amounts to more hunger among seniors
11. David H. Koch donates $10 million to Mount Sinais Jaffe Food Allergy Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... July 31, 2015 , ... Nutritional ... variety of nutritional and wellness products, announced the addition of Vincent Aquilino to ... therapy, active isolated stretching and the prevention and rehabilitation of injuries, has spent ...
(Date:7/31/2015)... ... July 31, 2015 , ... India Network Foundation ... temporary work, study or family visit for the past 25 years. As India Network ... are able to travel and spend time with their children and grand children. ...
(Date:7/31/2015)... ... July 31, 2015 , ... People love ... purchasing disability insurance, where price is an important factor to clients when choosing ... insurance carrier, offers the Preferred Producer Multi-Life Discount program, where advisers pass savings ...
(Date:7/31/2015)... ... July 31, 2015 , ... With the recent buzz ... individuals who remain undiagnosed, treatment options for patients are becoming more prevalent than ... therapy due to its overall lack of comfort and highly invasive nature, oral ...
(Date:7/30/2015)... ... July 30, 2015 , ... Dale Sky Jones, Executive Chancellor of ... the International Cannabis Professionals Expo held at the Caribe Royal All Suites Hotel and ... Professionals Expo is the largest medical cannabis expo in the country and this ...
Breaking Medicine News(10 mins):Health News:NPI Welcomes Vincent Aquilino to Board of Directors 2Health News:India Network Visitor Health Insurance Announces Completion of Food Grains Distribution to Godavari Pushkaram Visitors, Andhra Pradesh, India 2Health News:India Network Visitor Health Insurance Announces Completion of Food Grains Distribution to Godavari Pushkaram Visitors, Andhra Pradesh, India 3Health News:Secura Consultants Gives Advisers Competitive New Edge with Multi-Life Discount Program 2Health News:Oravan Sleep Apnea Device Gains Traction in Sleep Industry 2Health News:Finally…First Ever Professional Training Event for Doctors and Nurses Wanting to Offer Medical Marijuana Recommendations to Patients 2Health News:Finally…First Ever Professional Training Event for Doctors and Nurses Wanting to Offer Medical Marijuana Recommendations to Patients 3Health News:Finally…First Ever Professional Training Event for Doctors and Nurses Wanting to Offer Medical Marijuana Recommendations to Patients 4Health News:Finally…First Ever Professional Training Event for Doctors and Nurses Wanting to Offer Medical Marijuana Recommendations to Patients 5
... Gordon HealthDay Reporter , TUESDAY, Jan. 24 ... heartburn and other signs of gastroesophageal reflux don,t get ... research. And, taking these medications when there ... developing a respiratory infection, reports the study. "There,s ...
... least 10 percent of students at a single college could ... live off campus are drinking more and engaging in more ... research suggests. In contrast, hosts of parties held on ... their gatherings, according to the study. The research also ...
... 24 (HealthDay News) -- If you have gout, drinking enriched ... new research suggests. The new study included 120 patients ... four months. They were divided into three treatment groups that ... powder enriched with glycomacropeptide (GMP) and G600 milk fat extract ...
... HealthDay Reporter , TUESDAY, Jan. 24 (HealthDay News) -- New ... enlarged prostate gland, may help slow the progression of early ... some men. Prostate cancer can grow and spread slowly, ... so-called watchful waiting when the cancer is first diagnosed. Avodart ...
... paper from Rhode Island Hospital reports on the impact ... the upcoming revision to the Diagnostic and Statistical Manual, ... believe these changes could result in false-negative diagnoses for ... of Clinical Psychiatry and is now available online ...
... 2012, the annual scientific meeting of the American College ... health care journalists. Don,t miss the opportunity to report ... physician group in the United States. More than 250 ... its subspecialties, and issues in practice management and health ...
Cached Medicine News:Health News:Heartburn Meds Won't Help, May Harm Kids With Asthma 2Health News:Heartburn Meds Won't Help, May Harm Kids With Asthma 3Health News:Study: Off-campus college party hosts drink more than attendees 2Health News:Study: Off-campus college party hosts drink more than attendees 3Health News:Enriched Skim Milk Good for Gout, Study Suggests 2Health News:Drug May Slow Early Prostate Cancer: Study 2Health News:The impact of deleting 5 personality disorders in the new DSM-5 2
(Date:7/30/2015)... SAN DIEGO, July 30, 2015  ResMed Inc. (NYSE: ... ended June 30, 2015.  Revenue for the quarter was ... quarter ended June 30, 2014 (a 17 percent increase ... million, consistent with the quarter ended June 30, 2014. ... consistent with the quarter ended June 30, 2014.  ...
(Date:7/30/2015)... , July 30, 2015  Unichem Pharmaceuticals ( ... one lot of Hydrochlorothiazide tablets 25 mg 1000-count bottle ... as a precautionary measure due to the identification of ... product. The risk associated with mistakenly ... is the increased probability of experiencing Clopidogrel,s side effects ...
(Date:7/30/2015)... , July 30, 2015  Amgen (NASDAQ: AMGN ... partner and managing director of Warburg Pincus LLC, to the ... to welcome Fred Hassan and the deep, global ... Board," said Robert A. Bradway , chairman and chief ... to innovation will serve Amgen well." Mr. Hassan ...
Breaking Medicine Technology:ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 3ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 4ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 5ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 6ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 7ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 8ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 9ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 10ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 11ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 12ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 13ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 14ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 15ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 16Unichem Pharmaceuticals (USA), Inc. Issues a Voluntary Nationwide Recall of Hydrochlorothiazide Tablets Due to the Potential Presence of Foreign Tablets 2Amgen Announces Appointment Of Fred Hassan To Board Of Directors 2Amgen Announces Appointment Of Fred Hassan To Board Of Directors 3
... Feb. 3, 2011 Hospira, Inc. (NYSE: ... today announced U.S. Food and Drug Administration (FDA) approval ... oncology drug approved in the United States. The medication ... U.S. sales of more than $140 million. Hospira,s topotecan ...
... Feb. 3, 2011 Carrot Medical, a leading designer ... for 2010. During the year, Carrot Medical achieved significant ... secured additional private financing. Carrot Medical, recognized ... an Information Technology solution that integrates medical images and ...
Cached Medicine Technology:Hospira Announces FDA Approval of Topotecan Injection 2Carrot Medical Reports 2010 Growth in Sales and Financing, Optimism for 2011 2
... epTIPS Filter have an integrated ... without "self-sealing" additives. This filter provides ... by aerosols, and it does not ... incorrect pipetting. Samples can then be ...
... Designed To Mark The X & Y ... For Accurate Axial Alignment. 11mm Inner Diameter & ... Limbus. , ,Removes The Guess Work Associated With Hand-Held ... Tonometer Tip Slit-Lamp Housing To Ensure A More ...
Inquire...
... bottom allows easy withdrawal of solution ,• ... Nesting ring allows easy separation ... 4, 8, and 12 channel pipettors. Angled ... of practically all of the solution. The ...
Medicine Products: