Navigation Links
Mount Sinai researchers discover mechanism behind development of autoimmune hepatitis
Date:7/23/2013

A gene mutation disrupts the activity of certain immune cells and causes the immune system to erroneously attack the liver, according to a new animal study from the Icahn School of Medicine at Mount Sinai. The findings, published in the Journal of Clinical Investigation, will provide a new model for studying drug targets and therapies for Autoimmune Hepatitis (AIH), a condition for which the only treatment options are short-acting steroids or liver transplant.

T-cells, immune cells created in an organ called the thymus, grow into healthy T-cells with the help of medullary thymic epithelial cells (mTECs). mTECs act as coaches to T-cells to teach them when to attack tissue that might be harmful and when to leave it alone. T-cells that attack healthy body tissue are programmed to die. Led by Konstantina Alexandropoulos, PhD, Associate Professor of Medicine in the Division of Clinical Immunology at Mount Sinai, the research team sought to create a model for understanding why certain immune cells called T-cells inappropriately attack healthy tissues in the body, leading to inflammation and autoimmune diseases like lupus, rheumatoid arthritis, and AIH.

Dr. Alexandropoulos and her team, consisting of Anthony Bonito, first author and PhD candidate at Mount Sinai and contributing author Costica Aloman, PhD, former Assistant Professor of Medicine in the Division of Liver Diseases at Mount Sinai, created mutations in a gene called Traf6 in a mouse model, which caused depletion of mTECs. The research team hypothesized that without mTECs to coach them, T-cells would aberrantly attack healthy cells. Surprisingly, while the depletion of mTECs did cause an autoimmune reaction, the T-cells homed directly to the liver and attacked it rather than other healthy tissue.

"We thought that deleting Traf6 would trigger an autoimmune reaction due to a depletion of mTECs, but did not expect the autoimmune response to be specific to the liver," said Dr. Alex
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Mountain States Health Alliance Selects BESLER Consulting’s Revenue Recovery Services
2. World-Renowned Gastroenterologist Jean-Frédéric Colombel, MD, Joins the Icahn School of Medicine at Mount Sinai
3. Mesh Lawsuits Involving C.R. Bard, Ethicon Transvaginal Mesh Devices Continue to Mount in New Jersey State Litigation, Bernstein Liebhard LLP Reports
4. Women’s Choice Award® Honors Mount View Care Center As Most Recommended by Women
5. Biomet Hip Lawsuits Mount, as Cases in Federal Litigation Near 500, Bernstein Liebhard LLP Reports
6. The Mount Sinai Medical Center Awarded Advanced Certification as Comprehensive Stroke Center by The Joint Commission
7. Mount Sinai Queens Is Ranked In Top 10 Percent of Hospitals In the U.S. for Adoption of Electronic Medical Records
8. SouthEast Alaska Regional Health Consortium & Mount Edgecumbe Hospital Retain B. E. Smith to Recruit New CNO
9. Kenneth Davis, MD, President and CEO of The Mount Sinai Medical Center, to Speak on the Future of Medicine at the Aspen Ideas Festival in Colorado from June 26th to July 2nd, 2013
10. Mirena Lawsuit News: Bernstein Liebhard LLP Comments on Mounting Reports of Mirena Side Effects, Including Device Migration, Uterine Perforations
11. Mount Sinai Tops the List in New York Magazine’s 2013 “Best Doctors” Issue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... considered nearly eradicated. Each year only a few hundred ... of Bonn, together with colleagues from Gabon, are reporting ... resist the vaccine protection to a considerable extent was ... in 2010. The pathogen could also potentially have infected ... the magazine PNAS . , The polio epidemic ...
(Date:8/21/2014)... Maryland (PRWEB) August 21, 2014 As ... the U.S. Pharmacopeial Convention (USP) has joined with the ... threat posed by the illegal online sale of medicines. ... benefits of medicines and foods is a core mission ... health around the world,” said Ronald T. Piervincenzi, chief ...
(Date:8/21/2014)... It's a terrible thing when a young adult, ... substance abuse issue. When that happens to a teenager in ... reliable help from the qualified substance abuse therapists at a ... easy for those young adults living in Pompano Beach, FL ... , Thankfully there is a new helpline operating for ...
(Date:8/21/2014)... CA (PRWEB) August 21, 2014 David ... is a short but powerful collection of quotes from ... uplift and inspire other budding entrepreneurs on their challenging ... proud to announce the inclusion of President and Founder ... from highly successful and self-made celebrities such as Oprah ...
(Date:8/21/2014)... by T-type calcium channels in the thalamic reticular ... calcium. These channels enable thalamic reticular nucleus neurons ... enter a hyper-excited state. , In order to ... seizures, the researchers conducted an experiment to induce ... to delete the T-type calcium channel CaV3.3. The ...
Breaking Medicine News(10 mins):Health News:Polio: Mutated virus breaches vaccine protection 2Health News:USP Joins Efforts to Halt Illegal Online Drug Sales 2Health News:Young Adults in Pompano Beach, FL Are Finding Success With Innovative New Helpline 2Health News:Earth Source Organics President Audrey Darrow Featured in New David Mullings Book 2
... , FRIDAY, July 29 (HealthDay News) -- Some ethnic groups are ... organs as they gain weight, according to a new study. ... artery disease, is more common among people from South Asia, the ... journal PLoS ONE . "The new study showed South ...
... may also be contributing to hearing loss. Scientists mapped ... The distinctive roar of a Harley,s engine is ... noise for motorcyclists is actually generated by air whooshing ... sound can exceed safe levels. Now, scientists have identified ...
... testing at local emergency departments shows that hospitals miss opportunities ... with HIV, even when a regular testing program is in ... to the July issue of Annals of Emergency Medicine ... (CDC). The supplement includes a series of studies on HIV ...
... When people recognize voices, part of what helps make ... differently. But individuals with dyslexia don,t experience this familiar ... impairment." Tyler Perrachione with the Massachusetts Institute of ... language use the same words, they say those words ...
... protect skin cells from the sun,s ultraviolet radiation, according ... Barcelona and the CSIC (Spanish National Research Council). The ... in sun protection products. Ultraviolet (UV) rays emitted ... skin complaints, causing skin cancer, sunburn and solar erythema, ...
... The U.S. Food and Drug Administration should gather the ... the 35-year-old 510(k) clearance process for medical devices, says a ... process lacks the legal basis to be a reliable premarket ... devices and cannot be transformed into one, concluded the committee ...
Cached Medicine News:Health News:Some Ethnic Groups More Vulnerable to Dangerous Fat 2Health News:Study shows missed opportunities for HIV diagnosis in emergency departments 2Health News:Study shows missed opportunities for HIV diagnosis in emergency departments 3Health News:Dissecting dyslexia: Linking reading to voice recognition 2Health News:Dissecting dyslexia: Linking reading to voice recognition 3Health News:Grapes protect against ultraviolet radiation 2Health News:FDA should invest in developing a new regulatory framework to replace flawed 510(k) medical device clearance process 2Health News:FDA should invest in developing a new regulatory framework to replace flawed 510(k) medical device clearance process 3
(Date:8/20/2014)... NEW YORK , Aug. 20, ... a new market research report is ... The Market for Hospital-Acquired Infection Control ... http://www.reportlinker.com/p01618925/The-Market-for-Hospital-Acquired-Infection-Control-Sterilization-Disinfection-Testing-and-Treatment.html ... and healthcare-associated infections (HAIs), demand has ...
(Date:8/20/2014)... 20, 2014 Reportlinker.com announces that ... in its catalogue: Personal Accident ... and Opportunities to 2018 ... report provides in depth market analysis, information ... and health insurance segment, including: - The ...
(Date:8/20/2014)... , Aug. 20, 2014 Torrance ... be using advanced, ventilator technology from Covidien to ... care for patients. The acute ... naturally, compared to conventional mechanical ventilation, and help ... as possible. Patients on mechanical ventilation are often ...
Breaking Medicine Technology:The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 2The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 3The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 4The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 5The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 6Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 2Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 3Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 4Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 5Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 6Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 7Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 8Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 9Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 10Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 11Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 12Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 13Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 14Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 15Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 16Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 17Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 18Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 19Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 20Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 21Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 22Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 23Torrance Memorial Medical Center Acquires Advanced Ventilator Technology to Enhance Patient Care 2
... Corporation (NASDAQ: DYNT ) today announced results for ... 2011. Sales for the quarter ended December 31, ... the quarter ended December 31, 2010. Sales for the six ... $16,272,232, compared to $16,118,635 for the six months ended December ...
... Company (Nasdaq: PRGO ; TASE) announced that ... tablets, the store brand equivalent to Schering-Plough,s Claritin-D® 12 ... is indicated for the treatment of nasal allergy symptoms. ... to data provided by Wolters, Kluwer. ...
Cached Medicine Technology:Dynatronics Announces Second Quarter Results 2Dynatronics Announces Second Quarter Results 3Dynatronics Announces Second Quarter Results 4Perrigo Announces the Launch of Loratadine-D 12 Store Brand Labels -- the First Store Brand Launch That Compares to Claritin-D® 12 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: