Navigation Links
Mount Sinai researchers discover mechanism behind development of autoimmune hepatitis
Date:7/23/2013

A gene mutation disrupts the activity of certain immune cells and causes the immune system to erroneously attack the liver, according to a new animal study from the Icahn School of Medicine at Mount Sinai. The findings, published in the Journal of Clinical Investigation, will provide a new model for studying drug targets and therapies for Autoimmune Hepatitis (AIH), a condition for which the only treatment options are short-acting steroids or liver transplant.

T-cells, immune cells created in an organ called the thymus, grow into healthy T-cells with the help of medullary thymic epithelial cells (mTECs). mTECs act as coaches to T-cells to teach them when to attack tissue that might be harmful and when to leave it alone. T-cells that attack healthy body tissue are programmed to die. Led by Konstantina Alexandropoulos, PhD, Associate Professor of Medicine in the Division of Clinical Immunology at Mount Sinai, the research team sought to create a model for understanding why certain immune cells called T-cells inappropriately attack healthy tissues in the body, leading to inflammation and autoimmune diseases like lupus, rheumatoid arthritis, and AIH.

Dr. Alexandropoulos and her team, consisting of Anthony Bonito, first author and PhD candidate at Mount Sinai and contributing author Costica Aloman, PhD, former Assistant Professor of Medicine in the Division of Liver Diseases at Mount Sinai, created mutations in a gene called Traf6 in a mouse model, which caused depletion of mTECs. The research team hypothesized that without mTECs to coach them, T-cells would aberrantly attack healthy cells. Surprisingly, while the depletion of mTECs did cause an autoimmune reaction, the T-cells homed directly to the liver and attacked it rather than other healthy tissue.

"We thought that deleting Traf6 would trigger an autoimmune reaction due to a depletion of mTECs, but did not expect the autoimmune response to be specific to the liver," said Dr. Alex
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Mountain States Health Alliance Selects BESLER Consulting’s Revenue Recovery Services
2. World-Renowned Gastroenterologist Jean-Frédéric Colombel, MD, Joins the Icahn School of Medicine at Mount Sinai
3. Mesh Lawsuits Involving C.R. Bard, Ethicon Transvaginal Mesh Devices Continue to Mount in New Jersey State Litigation, Bernstein Liebhard LLP Reports
4. Women’s Choice Award® Honors Mount View Care Center As Most Recommended by Women
5. Biomet Hip Lawsuits Mount, as Cases in Federal Litigation Near 500, Bernstein Liebhard LLP Reports
6. The Mount Sinai Medical Center Awarded Advanced Certification as Comprehensive Stroke Center by The Joint Commission
7. Mount Sinai Queens Is Ranked In Top 10 Percent of Hospitals In the U.S. for Adoption of Electronic Medical Records
8. SouthEast Alaska Regional Health Consortium & Mount Edgecumbe Hospital Retain B. E. Smith to Recruit New CNO
9. Kenneth Davis, MD, President and CEO of The Mount Sinai Medical Center, to Speak on the Future of Medicine at the Aspen Ideas Festival in Colorado from June 26th to July 2nd, 2013
10. Mirena Lawsuit News: Bernstein Liebhard LLP Comments on Mounting Reports of Mirena Side Effects, Including Device Migration, Uterine Perforations
11. Mount Sinai Tops the List in New York Magazine’s 2013 “Best Doctors” Issue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2015)... FL (PRWEB) May 02, 2015 We ... selected The Delray Recovery Center as one of the ... is known in the addiction treatment field for their ... members to innovate and to continue their educational efforts. ... positive workplace environment, never forgetting their purpose – to ...
(Date:5/2/2015)... On Tuesday April 7th, the patient care ... celebrate improvements in patient care. In 2014 the hospital, ... zero acquired ventilator associated infections, zero central line associated ... also recently named a Top Performer by the Joint ... the teamwork of staff from all departments involved in ...
(Date:5/2/2015)... As a nonsurgical staple in ... face, neck and décolleté, radiofrequency energy is proving ... for the success of vulvovaginal rejuvenation. In a ... Council, ThermiGyn’s Women’s Health Clinical Advisory Board Chairman ... ThermiGyn’s temperature controlled radio frequency, specifically that of ...
(Date:5/2/2015)... With the success that Veatch Dental Consulting has ... Neida Miranda and Alex Shields to the team. With Neida ... years of combined experience working with dentists to ensure their ... for 8 years. She was certified as dental assistant ... positive attitude and showing the importance of oral hygiene to ...
(Date:5/1/2015)... and Caicos Islands, BWI (PRWEB) May 02, 2015 ... new website! It is http://www.thevenetiangracebay.com , and ... and it incorporates the stunning white and attractive turquoise ... a study of Google, sixty seven percent of leisure ... The study showed that smartphones were used in the ...
Breaking Medicine News(10 mins):Health News:The Delray Recovery Center Named 2015 Top Workplace 2Health News:East Liverpool City Hospital Celebrates Patient Care Improvements 2Health News:Study Demonstrates Efficacy of Temperature Controlled Radiofrequency for Vulvovaginal Laxity 2Health News:Study Demonstrates Efficacy of Temperature Controlled Radiofrequency for Vulvovaginal Laxity 3Health News:Veatch Dental Consulting Services Welcomes New Team Members 2Health News:Turks and Caicos Resort, The Venetian on Grace Bay, Launches New Web Presence 2
... TeleHealth Services , the nation,s ... staff interactive education solutions, today announced they will be ... the annual Healthcare Information and Management Systems Society (HIMSS) ... on-demand patient and staff education system, has been installed ...
... today announced the introduction of DNA shearing service ... years, Covaris instruments have become the gold standard ... step for next generation sequencing. The Covaris ... sequencing platforms. This process is highly reproducible ...
... Standards within HIT Solutions to Help Improve Patient ... Greenway Medical Technologies Inc., a leading ... practice management and interoperability solution has announced its ... Society (HIMSS) and Integrating the Health Enterprise (IHE) ...
... Ind., April 2 Despite government efforts to address ... 1998 Racial and Ethnic Health Disparities Initiative, there has ... and early death than Caucasians(1).The statistics are alarming:, ... African-Americans are 1.6 times more likely to have ...
... bouts of excessive consumption, CDC notes , , THURSDAY, April 2 ... most common among whites, males, people ages 18 to 34, ... to a study released Thursday. , The study defined binge ... , The U.S. Centers for Disease Control and Prevention (CDC) ...
... Discovery could lead to ways of regrowing damaged cardiac tissue, ... a longstanding mystery, scientists have found that the human heart ... although the rate of new cell production slows with age. ... of Science , could open a new path for ...
Cached Medicine News:Health News:TeleHealth Services Announces TIGR On-Demand Video Patient Education Version 7 Unveiling at HIMSS 2009 2Health News:TeleHealth Services Announces TIGR On-Demand Video Patient Education Version 7 Unveiling at HIMSS 2009 3Health News:Covaris Introduces DNA Shearing Service 2Health News:Greenway Medical Technologies Continues to Champion Interoperability Efforts with Extensive Participation in HIMSS' 2009 Interoperability Showcase 2Health News:Greenway Medical Technologies Continues to Champion Interoperability Efforts with Extensive Participation in HIMSS' 2009 Interoperability Showcase 3Health News:Greenway Medical Technologies Continues to Champion Interoperability Efforts with Extensive Participation in HIMSS' 2009 Interoperability Showcase 4Health News:Health Disparities Among Minority Populations Getting Worse 2Health News:Health Disparities Among Minority Populations Getting Worse 3Health News:Typical Binge Drinker Is Young White Male 2Health News:Human Heart Can Make New Cells 2Health News:Human Heart Can Make New Cells 3
(Date:5/1/2015)... , May 1, 2015  Misonix, Inc. (NASDAQ: ... that designs, manufactures and markets innovative therapeutic ultrasonic ... debridement, cosmetic surgery, laparoscopic surgery and other surgical ... results for the third quarter fiscal year 2015 ... scheduled a conference call that same day, Thursday, ...
(Date:5/1/2015)... NEW YORK , May 1, 2015  Shares ... over 70% of their value yesterday following the results ... company,s glaucoma therapy, Rhopressa.  Despite the trial failing to ... indicates that positive results may come from future studies. ... a brief company overview, current pipeline, financial review, analyst ...
(Date:4/30/2015)... 2015 Omnicell, Inc. (NASDAQ: OMCL ), a ... healthcare systems, today announced results for its first quarter ... for the first quarter of 2015 was $116.2 million, ... of 2014, and down $5.3 million or 4.4% from ... 2015 net income as reported in accordance with U.S. ...
Breaking Medicine Technology:Misonix, Inc. To Report Third Quarter Fiscal Year 2015 Financial Results On Thursday, May 7, 2015 2All is Not Lost for Aerie Pharmaceuticals - VLM Research Issued by BrokerBank Securities, Inc. 2Omnicell Announces First Quarter 2015 Results 2Omnicell Announces First Quarter 2015 Results 3Omnicell Announces First Quarter 2015 Results 4Omnicell Announces First Quarter 2015 Results 5Omnicell Announces First Quarter 2015 Results 6Omnicell Announces First Quarter 2015 Results 7Omnicell Announces First Quarter 2015 Results 8Omnicell Announces First Quarter 2015 Results 9Omnicell Announces First Quarter 2015 Results 10Omnicell Announces First Quarter 2015 Results 11Omnicell Announces First Quarter 2015 Results 12Omnicell Announces First Quarter 2015 Results 13Omnicell Announces First Quarter 2015 Results 14Omnicell Announces First Quarter 2015 Results 15Omnicell Announces First Quarter 2015 Results 16Omnicell Announces First Quarter 2015 Results 17Omnicell Announces First Quarter 2015 Results 18Omnicell Announces First Quarter 2015 Results 19Omnicell Announces First Quarter 2015 Results 20Omnicell Announces First Quarter 2015 Results 21Omnicell Announces First Quarter 2015 Results 22Omnicell Announces First Quarter 2015 Results 23Omnicell Announces First Quarter 2015 Results 24Omnicell Announces First Quarter 2015 Results 25Omnicell Announces First Quarter 2015 Results 26Omnicell Announces First Quarter 2015 Results 27
... Mont., Feb. 1, 2012 Bacterin International Holdings ... leader in the development of revolutionary bone graft material ... Hayden IR , a 15-year-old, highly recognized, national investor ... relations program and raise its visibility and strengthen its ...
... 1, 2012  Arena Pharmaceuticals, Inc. (NASDAQ: ARNA ... Food and Drug Administration (FDA) has notified Arena that ... discuss the lorcaserin New Drug Application (NDA) resubmission will ... and details of the meeting will be published in ...
Cached Medicine Technology:Bacterin Retains Hayden IR to Develop Strategic Investor Relations Program 2Bacterin Retains Hayden IR to Develop Strategic Investor Relations Program 3Bacterin Retains Hayden IR to Develop Strategic Investor Relations Program 4Arena Pharmaceuticals Receives Notice from FDA of Advisory Committee Meeting for Lorcaserin 2Arena Pharmaceuticals Receives Notice from FDA of Advisory Committee Meeting for Lorcaserin 3Arena Pharmaceuticals Receives Notice from FDA of Advisory Committee Meeting for Lorcaserin 4
... cardiovascular system PLUS ... high-performance transesophageal cardiovascular imaging system ... phased array echocardiography system that ... images, even on your most ...
MAGNETOM Symphony, an imaging system that offers 1.5T performance and top image quality in a short bore design....
MAGNETOM Avanto, the worlds first Tim MRI system, provides unsurpassed image quality, enhanced productivity, and greater patient comfort....
... Medical Billing Assistant (MBA) ... medical billing and practice management ... on Microsoft SQL Server technology ... reporting capabilities and account receivable ...
Medicine Products: