Navigation Links
Mount Sinai researcher finds unexpected temperature sensation for a light detector
Date:3/11/2011

New research from Mount Sinai School of Medicine has discovered that rhodopsin, a pigment of the retina that is responsible for the first events in the perception of light, may also be involved in temperature sensation. This detection had not been revealed in previous studies.

The work emerged from a collaboration between the laboratory of Andrew Chess, M.D., Professor in the Departments of Neuroscience, Developmental and Regenerative Biology and Genetics and Genomic Sciences at Mount Sinai, and the laboratory of Craig Montell, Ph.D., Professor of Biological Chemistry at Johns Hopkins School of Medicine. Their paper, titled "Function of rhodopsin in temperature discrimination in Drosophila," is published in the March 11 edition of Science.

The research focused on rhodopsin in Drosophila larvae, commonly known as fruit flies. The temperature-detection function of rhodopsin allows the Drosophila larvae to move to their preferred temperature of 18 degrees Celsius (64.4 degrees Fahrenheit). This ability depends on a thermosensory signaling pathway that includes a heterotrimeric guanine nucleotide-binding protein, or G-protein.

"It is very surprising that rhodopsin has a role in temperature sensation, as it was thought to be completely devoted to its well-known role as a light sensor," said Dr. Chess, Mount Sinai School of Medicine. "This function of rhodopsin allows temperature discrimination in the comfortable range."

This new role for rhodopsin emerged from studies of the process that results in the activation of a temperature-sensor protein known as a TRPA1, which Dr. Montell's group has been studying.

The researchers released about 75 larvae onto a plate with two temperature zones. Half of the plate was kept at 18 degrees Celsius and the other half ranged from 14 to 32 degrees Celsius. After ten minutes, the larvae lacking rhodopsin could not discriminate temperatures in comfortable range, just like the larvae lacking TRPA1.

The mouse gene melanopsin is the closest mouse gene to Drosophila rhodopsin. Mouse melanopsin can functionally replace the thermosensory function of Drosophila rhodopsin.

The Drosophila larva has peripheral neurons that mediate thermosensation. These neurons are distinct from neurons that allow detection of light. Since the rhodopsins generally have low susceptibility to thermal activation, there is likely a distinct, yet-to-be-discovered, protein that allows thermal activation of rhodopsin.


'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. Number of Mountain Bike Injuries Dropping
2. Long- and short-sleeved physician workwear receive same amount of bacterial and MRSA contamination
3. New national study finds mountain bike-related injuries down 56 percent
4. FDA Lowers Amount of Acetaminophen Allowed in Prescription Painkillers
5. Mount Sinai develops first screening tool for war veterans to assess traumatic brain injury
6. Mount Sinai researchers make major breakthrough in melanoma research
7. Mount Sinai first in US to implant aortic valve prosthesis to treat severe aortic stenosis
8. Mount Sinai researchers discover origin of immune cells in the brain
9. Mount Sinai researchers discover why cocaine is so addictive
10. Mount Sinai researchers find new target to improve pain management
11. Small Amounts of Dark Chocolate May Guard Against Heart Failure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... ... , ... People across the U.S. are sharpening their pencils and honing their ... in which patients and their families pay tribute to a genetic counselor by nominating ... of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, ...
(Date:6/24/2016)... York, NY (PRWEB) , ... June 24, 2016 ... ... publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as a ... that “the most beautiful women in the world, and the most handsome men, ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... feeding the Frederick area economy by obtaining investment capital for emerging technology companies. ... 2½ years that have already resulted in more than a million dollars of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group ... Tournament held on June 20th at the Woodmont Country Club at 1201 Rockville ... an organization dedicated to helping service members that have been wounded in battle and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Research and Markets has announced ... Applications, Technologies, Forecasts" report to their offering. ... Smart Skin, Structural Health Monitoring, Composite Smart Structures, ... involves electronic and/or electrical components and circuits that ... such as vehicle bodies or conformally placed upon ...
(Date:6/24/2016)... 2016 Research and Markets has announced ... Diagnostic Tests" report to their offering. ... The World Market for Companion Diagnostics covers ... Market analysis in the report includes the following: ... Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... June 24, 2016  Arkis BioSciences, a leading ... and more durable cerebrospinal fluid treatments, today announced ... Series-A funding is led by Innova Memphis, followed ... other private investors.  Arkis, new financing will accelerate ... the market release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: