Navigation Links
Mount Sinai researcher finds unexpected temperature sensation for a light detector
Date:3/11/2011

New research from Mount Sinai School of Medicine has discovered that rhodopsin, a pigment of the retina that is responsible for the first events in the perception of light, may also be involved in temperature sensation. This detection had not been revealed in previous studies.

The work emerged from a collaboration between the laboratory of Andrew Chess, M.D., Professor in the Departments of Neuroscience, Developmental and Regenerative Biology and Genetics and Genomic Sciences at Mount Sinai, and the laboratory of Craig Montell, Ph.D., Professor of Biological Chemistry at Johns Hopkins School of Medicine. Their paper, titled "Function of rhodopsin in temperature discrimination in Drosophila," is published in the March 11 edition of Science.

The research focused on rhodopsin in Drosophila larvae, commonly known as fruit flies. The temperature-detection function of rhodopsin allows the Drosophila larvae to move to their preferred temperature of 18 degrees Celsius (64.4 degrees Fahrenheit). This ability depends on a thermosensory signaling pathway that includes a heterotrimeric guanine nucleotide-binding protein, or G-protein.

"It is very surprising that rhodopsin has a role in temperature sensation, as it was thought to be completely devoted to its well-known role as a light sensor," said Dr. Chess, Mount Sinai School of Medicine. "This function of rhodopsin allows temperature discrimination in the comfortable range."

This new role for rhodopsin emerged from studies of the process that results in the activation of a temperature-sensor protein known as a TRPA1, which Dr. Montell's group has been studying.

The researchers released about 75 larvae onto a plate with two temperature zones. Half of the plate was kept at 18 degrees Celsius and the other half ranged from 14 to 32 degrees Celsius. After ten minutes, the larvae lacking rhodopsin could not discriminate temperatures in comfortable range, just like the larvae lacking TRPA1.

The mouse gene melanopsin is the closest mouse gene to Drosophila rhodopsin. Mouse melanopsin can functionally replace the thermosensory function of Drosophila rhodopsin.

The Drosophila larva has peripheral neurons that mediate thermosensation. These neurons are distinct from neurons that allow detection of light. Since the rhodopsins generally have low susceptibility to thermal activation, there is likely a distinct, yet-to-be-discovered, protein that allows thermal activation of rhodopsin.


'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. Number of Mountain Bike Injuries Dropping
2. Long- and short-sleeved physician workwear receive same amount of bacterial and MRSA contamination
3. New national study finds mountain bike-related injuries down 56 percent
4. FDA Lowers Amount of Acetaminophen Allowed in Prescription Painkillers
5. Mount Sinai develops first screening tool for war veterans to assess traumatic brain injury
6. Mount Sinai researchers make major breakthrough in melanoma research
7. Mount Sinai first in US to implant aortic valve prosthesis to treat severe aortic stenosis
8. Mount Sinai researchers discover origin of immune cells in the brain
9. Mount Sinai researchers discover why cocaine is so addictive
10. Mount Sinai researchers find new target to improve pain management
11. Small Amounts of Dark Chocolate May Guard Against Heart Failure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... April 28, 2017 , ... Datta ... M.D. has joined the revolutionary endoscopic practice under Dr. Datta. Patel is a ... Pain Medicine. The patented, revolutionary eDiscSculpt Technique created and used by Datta Endoscopic ...
(Date:4/28/2017)... ... April 28, 2017 , ... People are starting to ... “Wearing a hearing aid doesn’t have the stigma it had when great-grandpa wore his ... of Greater Boston, in a NALA North American Speaker Series (NASS) segment. ...
(Date:4/28/2017)... ... April 28, 2017 , ... ... the Brooke Grove Foundation implement a Microsoft Dynamics GP solution that integrates to ... ERP expert that specializes in long-term care, Brooke Grove now has the capability ...
(Date:4/28/2017)... ... 2017 , ... Christie Medical Holdings, Inc. , with its market-leading ... Medical Inc. , a leader in infusion therapy and pain management. , Intravenous ... percent of hospital patients receiving a peripheral IV catheter as part of their treatment ...
(Date:4/27/2017)... ... April 27, 2017 , ... The American Brain Foundation ... Leadership in Neurology Award (PLINA). The couple joins a prestigious list of past ... Walter Mondale, actor Michael J. Fox and former U.S. Attorney General Janet Reno. ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017 Research and ... Pharmaceutical Contract Manufacturing Services Market Analysis By Service (Manufacturing, Research), ... Forecasts, 2014 - 2025" report to their offering. ... The Latin American pharmaceutical ... billion by 2025 Low drug registration cost in ...
(Date:4/19/2017)... The Mobile X-Ray product segment is the most ... the forecast period Mobile X-Ray segment is the ... X-Ray devices market, which is estimated to be valued at ... CAGR of 7% over the forecast period. Mobile X-Ray segment ... US$ 100 Mn in 2017 over 2016. The segment,s revenue ...
(Date:4/19/2017)... Global Prostate Cancer Therapeutics Market: Overview ... cancer therapeutics market analyzes the current and future ... prostate cancer, launch of promising emerging therapies, as ... drugs & therapeutic biological products, and high growth ... side effects are some of the drivers expected ...
Breaking Medicine Technology: