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Mount Sinai presents treatment trends, vaccine research, prognosis data at ASCO
Date:5/17/2012

uate to Determine Patient Risk (Abstract #10001, Monday, June 4, 2012, 3:15 PM-3:30 PM CT, Room S406)

A research team found that the staging system used in soft tissue sarcomatumors that develop in tissues such as muscles, tendons, fat, or blood vesselswas inadequate in helping clinicians evaluate disease severity, undermining their ability to determine prognosis and treatment course. Led by Robert Maki, MD, PhD, Medical Director of the Sarcoma Medical Oncology Program and Chief of Pediatric Hematology and Oncology at Mount Sinai School of Medicine, researchers evaluated a database of more than 8,000 patients using the criteria of versions six and seven of a staging system created by the American Joint Committee on Cancer (AJCC).

They found that in both of these versions, tumor size is not adequately addressed in determining relapse-free and overall survival. Tumor depth appears to be a less important factor than previously considered, if the size characteristics are taken into account. Patients with lymph node involvement without other metastases fared statistically worse than patients with large, high-grade tumors without nodal metastasis, findings that are not addressed in either version of the staging system.

According to Dr. Maki and his team, the primary tumor site, histology, and a larger number of size categories are critical factors in learning disease prognosis. They suggest patient-specific nomograms, i.e. charts detailing tumor characteristics, or other techniques as a better predictive model.

"Our research shows that the staging system for soft tissue sarcomas requires significant modification, and that a single staging system for this complex tumor type does not suffice to determine patient prognosis," said Dr. Maki. "Newer techniques may be more accurate to determine prognosis, help communicate risk, and choose the ideal treatment."

  • Predictive Model of Survival In a Subtype of Patients
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Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

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