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Mount Sinai presents treatment trends, vaccine research, prognosis data at ASCO
Date:5/17/2012

tly better overall survival after three years ( 89.1 percent) and progression-free survival (81.7 percent) compared to HPV-negative patients (70.5 and 58.8 percent, respectively). The outcomes were similar in the induction chemotherapy plus chemoradiotherapy group, with a three-year overall survival rate of 89.7 percent in the HPV-positive group and 68.2 percent in the HPV-negative group.

"The dramatic increase in the incidence of HPV-positive head and neck cancer is concerning," said Dr. Posner. "However, our research indicates that these patients have a much better prognosis with standard treatments than the traditional 'smoker-drinker' head and neck cancer patient. At Mount Sinai, we are pursuing opportunities to reduce the toxicity and long term complications of therapy in HPV-positive patients."

  • The PARADIGM Trial: Comparison of Two First-Line Therapies for Locally Advanced Head and Neck Cancer (Abstract #5501, Sunday, June 3, 2012, from 8:15AM-8:30AM CT, E354b)

    PARADIGM is a multicenter, Phase III trial of 145 patients randomized to receive sequential therapy with three chemotherapy drugs or chemoradiotherapy, in which the drugs are delivered at the same time. The enrollment goal for PARADIGM was 300 patients, but patient accrual was stopped at 145 due to limited enrollment in U.S. sites. In the sequential therapy group, three-year survival was 73 percent and progression-free survival was 67 percent. In the chemoradiotherapy group, three-year survival was 78 percent and progression-free survival was 73 percent.

    "Despite the early termination of PARADIGM, the results of treatment with sequential therapy and chemoradiotherapy are consistent," said Dr. Posner. "Excellent survival was seen in both treatment arms, a finding that warrants further study to help determine the best treatment course and tolerability of these therapies."

  • Current Staging System for Soft Tissue Sarcoma Inadeq
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Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

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