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Mount Sinai presents treatment trends, vaccine research, prognosis data at ASCO
Date:5/17/2012

urvival in these patients, Mount Sinai researchers led by William K. Oh, MD, Chief of the Division of Hematology and Medical Oncology of The Tisch Cancer Institute, have created a whole-blood molecular biomarker and successfully identified a robust six-gene model. Using blood from 202 men, the research team determined which patients were high risk and died within 2.2 years, and which were lower risk, living beyond 2.2 years. Having a clear prognosis for these patients will help determine treatment course and clinical trial suitability. The genes noted in the model suggest possible changes in the immune system related to late-stage disease that warrant further study as a target for immune-based therapies.

"There is an urgent need for predictive models that help assess how aggressive the disease is in prostate cancer patients," said Dr. Oh. "Our six-gene model will allow clinicians to better determine the course of action for their patients, determine clinical trial eligibility, and lead to more targeted studies in late stage disease."

  • Survival of Patients with Head and Neck Cancer Derived from Human Papillomavirus (HPV) (Abstract #5582, Saturday, June 2, 2012, 1:15-5:15 PM CT, S Hall A2

    For patients with a type of head and neck cancer called oropharyngeal squamous cell cancer, determining whether the cancer is HPV-positive or negative is an important predictive factor in assessing clinical outcomes. A team of researchers led by Marshall Posner, MD, Professor of Medicine and Medical Director of the Head and Neck Oncology Center at Mount Sinai, analyzed 280 patients treated between 2002 and 2011: 201 with HPV-positive cancer and 79 with HPV-negative cancer. Of the 280 patients, 106 were treated with induction chemotherapy followed by chemoradiotherapy, and 174 were treated with chemoradiotherapy alone.

    Patients with HPV-positive oropharyngeal squamous cell cancer treated with chemoradiotherapy alone had significan
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Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

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