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Mount Sinai presents treatment trends, vaccine research, prognosis data at ASCO
Date:5/17/2012

atology and Medical Oncology at Mount Sinai, and his team will describe a new multicenter study investigating a vaccine targeting multiple myeloma, a currently incurable blood cancer. Dr. Cho's team discovered that a gene called Melanoma Antigen Gene (MAGE)-A3 is highly expressed in multiple myeloma, and when that gene is "turned off," the cancer cells die and the disease cannot proliferate. Dr. Cho and his team are investigating a vaccine based on the protein produced by the MAGE-A3 gene that triggers an immune system response intended to kill multiple myeloma cells.

Paired with an adjuvant, or a chemical that boosts immune response, and white blood cells primed with the vaccine, the MAGE-A3 vaccine is administered to patients undergoing autologous stem cell transplant. The first dose is delivered six weeks before stem cell transplant; the primed white blood cells are infused three days after the stem cell transplant and boosted by a second vaccination ten days after the transplant. Over the next 270 days, the patient receives six additional booster vaccinations.

The study plans to enroll 16 patients. If a 50 percent response to the vaccination is achieved, the research team will initiate a study in a larger patient population to further evaluate clinical efficacy.

"While currently available treatments for multiple myeloma help patients live longer and with a better quality of life, this disease remains incurable," said Dr. Cho. "Immunotherapies have enormous potential in this patient population, and we hope the MAGE-A3 protein vaccine will bring us closer to a cure."

  • New Gene Model Predicts Survival in Prostate Cancer Patients Resistant to Hormone Therapy (Abstract #4516, Tuesday, June 5, 2012, 12:00PM-12:15PM CT, E Arie Crown Theater)

    Patients with prostate cancer who do not respond to hormone therapy have varying rates of long-term survival, ranging from months to several years. To better predict s
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Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

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