Navigation Links
Mount Sinai pioneers new cardiac imaging device
Date:8/16/2010

Researchers from Mount Sinai School of Medicine have for the first time developed a way to visualize coronary artery plaques vulnerable to rupture using multi-color computed tomography (CT), an innovation that will lead to better and earlier diagnosis of cardiovascular disease. The data are published in the September issue of Radiology.

Ruptures of atherosclerotic plaques are the cause of nearly 70 percent of heart attacks. High density lipoproteins (HDL), the "good" cholesterol, are drawn to plaques vulnerable to rupture and remove them from the arterial wall. The Mount Sinai team harnessed HDL by encapsulating tiny gold particles within it and injected them into mice. By using a sophisticated multi-color CT scanner, the researchers were able to see the gold particles as the HDL was targeting macrophages, or the cells that cause inflammation in the arterial wall, therefore illuminating the location of the vulnerable plaques.

"The use of multi-color CT and gold nanoparticles to visualize plaque will revolutionize cardiac imaging," said the research team leader, Zahi A. Fayad, PhD, Professor of Radiology and Medicine and the Director of the Translational and Molecular Imaging Institute at Mount Sinai School of Medicine. "The acquisition of this technology and development of this method will help us improve cardiovascular disease diagnosis in our patients, furthering our commitment to translational research. We look forward to continuing our study of this technology in the clinical setting."

Conventional CT detectors provide a gray image of the artery being studied, and do not provide contrast to differentiate types and density of tissue. In addition to showing the impact of the gold particles, spectral CT can simultaneously distinguish calcium deposits and contrast agents used such as iodine, which is often used to identify stenoses, or the narrowing of arteries, informing the severity of atherosclerosis and heart attack risk. Mount Sinai is the first institution in the world to use this scanner, made by Phillips Medical Systems, in a pre-clinical setting.

"There is a significant unmet need for imaging technology that visualizes plaque vulnerable to rupture," said the lead author of the work, David Cormode, PhD, Postdoctoral Fellow, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine. "The fact that the multi-color CT technique shows the gold particles, iodine and calcifications, provides us with a more complete picture of the nature of the atherosclerotic arteries."

Multi-color CT technology may also be beneficial in imaging other biological process and diseases, including cancer, kidney disease, and bowel diseases. The Mount Sinai team plans to continue studying the new scanner in additional animal studies and in humans.

"Mount Sinai has a decades-long history of making advances in cardiac imaging that have had a significant impact on the field and in patient care," said Valentin Fuster, MD, PhD, Director of Mount Sinai Heart, the Zena and Michael A. Wiener Cardiovascular Institute and the Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, The Mount Sinai Medical Center. "As the first center in the world to pioneer this imaging method, we are leading the charge once more in improving diagnostic tools that lessen the potentially devastating impact of heart disease."


'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. Mount Sinai leads Consortium of Food Allergy Research with $29.9 million grant
2. The Marilyn B. Gula Mountains of Hope Foundation donates additional research funds to TGen
3. Chicago Father and Son Team to Climb Mount Kilimanjaro for ShelterBox
4. AAU Big Mountain Jam Basketball Tournament To Be Played On SnapSports Flooring
5. Mount Sinai researchers find structural basis for incidence of skin cancers in a genetic disorder
6. Women who consume large amounts of tea have increased risk of rheumatoid arthritis
7. Albeo Releases Six New Surface Mount LED Lighting Fixtures
8. Green Drinks NYC and Green Mountain Energy Company Present Summer Bash at Solar One
9. The Mount Sinai Hospital Ranked in Top 25 of Best Children's Hospitals in Two Specialties by U.S. News & World Report
10. Mount Sinai researchers approaching universal treatment for all strains of influenza
11. Mountain Retreat for Women Whose Lives Have Been Touched by Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 2016 , ... The OSHA Training Center at Chabot-Las ... headquartered in Northern California, has issued an important reminder to employers to prevent ... Employers with workers exposed to high temperatures should establish a complete heat illness ...
(Date:6/27/2016)... ... ... "FCPX editors can now reveal their media with growing colorful split screen ... - CEO of Pixel Film Studios. , ProSlice Color brings the split screens ... reveal the media of their split screens with growing colorful panels. , ProSlice Color ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... health professionals, announced today its affiliation with Tennessee Counseling Association. This ... the network of the Tennessee Counseling Association, adding exclusive benefits and promotional offers. ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... today announced its strategic partnership with Connance, a healthcare industry leader providing ... companies’ proven, proprietary technology combine to provide health systems, hospitals and ambulatory ...
(Date:6/27/2016)... , ... June 27, 2016 , ... ... edge technology to revolutionize the emergency ambulance transport experience for the millions of ... of how Uber has disrupted the taxi industry through the use of technology. ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... One of Australia,s successful biotechnology scientists, Dr ... biotechnology company, Noxopharm Limited [ABN 50 608 966 123] ("Noxopharm"). Noxopharm ... on the ASX. Noxopharm is a clinic-ready company with ... 1 clinical study later this year. ... problems facing cancer patients - the ability of cancers to become ...
(Date:6/26/2016)... DUBLIN , June 27, 2016 Jazz ... the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act ... proposed acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... 11:59 p.m. (Eastern Daylight Time). As previously ... entered into a definitive merger agreement under which Jazz ...
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
Breaking Medicine Technology: