Navigation Links
Mount Sinai pioneers new cardiac imaging device
Date:8/16/2010

Researchers from Mount Sinai School of Medicine have for the first time developed a way to visualize coronary artery plaques vulnerable to rupture using multi-color computed tomography (CT), an innovation that will lead to better and earlier diagnosis of cardiovascular disease. The data are published in the September issue of Radiology.

Ruptures of atherosclerotic plaques are the cause of nearly 70 percent of heart attacks. High density lipoproteins (HDL), the "good" cholesterol, are drawn to plaques vulnerable to rupture and remove them from the arterial wall. The Mount Sinai team harnessed HDL by encapsulating tiny gold particles within it and injected them into mice. By using a sophisticated multi-color CT scanner, the researchers were able to see the gold particles as the HDL was targeting macrophages, or the cells that cause inflammation in the arterial wall, therefore illuminating the location of the vulnerable plaques.

"The use of multi-color CT and gold nanoparticles to visualize plaque will revolutionize cardiac imaging," said the research team leader, Zahi A. Fayad, PhD, Professor of Radiology and Medicine and the Director of the Translational and Molecular Imaging Institute at Mount Sinai School of Medicine. "The acquisition of this technology and development of this method will help us improve cardiovascular disease diagnosis in our patients, furthering our commitment to translational research. We look forward to continuing our study of this technology in the clinical setting."

Conventional CT detectors provide a gray image of the artery being studied, and do not provide contrast to differentiate types and density of tissue. In addition to showing the impact of the gold particles, spectral CT can simultaneously distinguish calcium deposits and contrast agents used such as iodine, which is often used to identify stenoses, or the narrowing of arteries, informing the severity of atherosclerosis and heart attack risk. Mount Sinai is the first institution in the world to use this scanner, made by Phillips Medical Systems, in a pre-clinical setting.

"There is a significant unmet need for imaging technology that visualizes plaque vulnerable to rupture," said the lead author of the work, David Cormode, PhD, Postdoctoral Fellow, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine. "The fact that the multi-color CT technique shows the gold particles, iodine and calcifications, provides us with a more complete picture of the nature of the atherosclerotic arteries."

Multi-color CT technology may also be beneficial in imaging other biological process and diseases, including cancer, kidney disease, and bowel diseases. The Mount Sinai team plans to continue studying the new scanner in additional animal studies and in humans.

"Mount Sinai has a decades-long history of making advances in cardiac imaging that have had a significant impact on the field and in patient care," said Valentin Fuster, MD, PhD, Director of Mount Sinai Heart, the Zena and Michael A. Wiener Cardiovascular Institute and the Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, The Mount Sinai Medical Center. "As the first center in the world to pioneer this imaging method, we are leading the charge once more in improving diagnostic tools that lessen the potentially devastating impact of heart disease."


'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. Mount Sinai leads Consortium of Food Allergy Research with $29.9 million grant
2. The Marilyn B. Gula Mountains of Hope Foundation donates additional research funds to TGen
3. Chicago Father and Son Team to Climb Mount Kilimanjaro for ShelterBox
4. AAU Big Mountain Jam Basketball Tournament To Be Played On SnapSports Flooring
5. Mount Sinai researchers find structural basis for incidence of skin cancers in a genetic disorder
6. Women who consume large amounts of tea have increased risk of rheumatoid arthritis
7. Albeo Releases Six New Surface Mount LED Lighting Fixtures
8. Green Drinks NYC and Green Mountain Energy Company Present Summer Bash at Solar One
9. The Mount Sinai Hospital Ranked in Top 25 of Best Children's Hospitals in Two Specialties by U.S. News & World Report
10. Mount Sinai researchers approaching universal treatment for all strains of influenza
11. Mountain Retreat for Women Whose Lives Have Been Touched by Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding emergency ... its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. Ogunleye ... M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. Ogunleye ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, ... Elite. The attorneys chosen by their peers for this recognition are considered among the ... Traurig Shareholders received special honors as members of this year’s Legal Elite Hall of ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The ... published in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Jazz Pharmaceuticals plc (Nasdaq: JAZZ ... Antitrust Improvements Act of 1976, as amended ("HSR"), with ... ("Celator"; Nasdaq: CPXX ) expired effective June ... As previously announced on May 31, 2016, Jazz ... under which Jazz Pharmaceuticals has commenced a tender offer ...
(Date:6/26/2016)... VEGAS , June 26, 2016 ... to value-based care operating models within the health care ... enable greater financial efficiency , Deloitte offers a ... the key business issues impacting efficient cost optimization: labor ... , These services facilitate better outcomes and better ...
(Date:6/24/2016)... OAKLAND, N.J. , June 24, 2016 /PRNewswire/ ... in the design, development and manufacturing of collagen ... and regeneration announced today that Bill Messer ... Sales and Marketing to further leverage the growing ... surgery medical devices. Bill joins the ...
Breaking Medicine Technology: