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Mount Sinai first in US to implant aortic valve prosthesis to treat severe aortic stenosis
Date:12/21/2010

David H. Adams, MD, Marie-Jose and Henry R. Kravis Professor and Chairman of the Department of Cardiothoracic Surgery, Samin K. Sharma, MD, the Zena and Michael A. Weiner Professor and Director of the Cardiac Catheterization Laboratory, and Annapoorna S. Kini, MD, Associate Professor and Associate Director of the Cardiac Catheterization Laboratory at The Mount Sinai Medical Center, have performed the first implantation of the Medtronic CoreValve Transcatheter Aortic Valve Prosthesis in the United States. The CoreValve System is a new device that treats severe aortic stenosis, which affects about 300,000 people worldwide. Designed to replace a diseased aortic heart valve percutaneously via a catheter, CoreValve potentially provides a safe and less invasive alternative to open heart surgery.

The normal aortic valve opens and closes each time the heart beats to allow blood to leave the pumping chamber of the heart. In many patients of advanced aged, the leaflets of the valve become calcified, leading to a narrowing or stenosis of the valve and symptoms which include shortness of breath on activity. Severe aortic stenosis mostly affects patients older than 70 years of age, and the standard-of-care is open heart surgery to replace the diseased valve. It is estimated over one-third of patients with severe aortic stenosis are ineligible for conventional surgery, and many more are at high risk by undergoing it. Left untreated, about half of patients with symptomatic severe aortic stenosis will die within one year.

"There is an enormous unmet need in this patient population for a safe and effective treatment," said Dr. Adams, who is also the National Co-Principal Investigator for the Medtronic CoreValve U.S. FDA Pivotal Trial, along with Dr. Jeff Popma, of the Beth Israel Deaconess Medical Center and Harvard Medical School. "CoreValve provides an exciting new option for these patients without the invasiveness of open heart surgery. We hope this FDA tr
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The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

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