Navigation Links
Mount Sinai finds promising clue to mechanism behind gene mutation that causes Parkinson's disease

Researchers at Mount Sinai School of Medicine have discovered a way that mutations in a gene called LRRK2 may cause the most common inherited form of Parkinson's disease. The study, published online this month in the journal Public Library of Science, shows that upon specific modification called phosphorylation, LRRK2 protein binds to a family of proteins called 14-3-3, which has a regulatory function inside cells. When there is a mutation in LRRK2, 14-3-3 is impaired, leading to Parkinson's. This finding explains how mutations lead to the development of Parkinson's, providing a new diagnostic and drug target for the disease.

Using one-of-a-kind mouse models developed at Mount Sinai School of Medicine, Zhenyu Yue, PhD, Associate Professor of Neurology and Neuroscience, and his colleagues, found that several common Parkinson's disease mutationsincluding one called G2019Sdisturb the specific phosphorylation of LRRK2.This impairs 14-3-3 binding with varying degrees, depending on the type of mutation.

"We knew that the LRRK2 mutation triggers a cellular response resulting in Parkinson's disease, but we did not know what processes the mutation disrupted," said Dr. Yue. "Now that we know that phosphorylation is disturbed, causing 14-3-3 binding to be impaired, we have a new idea for diagnostic analysis and a new target for drug development."

Dr. Yue's team also identified a potential enzyme called protein kinase A (PKA), responsible for the phosphorylation of LRRK2. Although the exact cellular functions disrupted by these changes are unclear, their study provides a starting point for understanding brain signaling that contributes to the disease. Recent studies have shown that 14-3-3 binds to other proteins implicated in inherited Parkinson's disease and has a neuroprotective function, and when the binding is impaired due to these mutations, the protection may be lost. The findings also demonstrate additional insight into the functional relevance of the LRRK2 and 14-3-3 interaction.

The presence of 14-3-3 in spinal fluid is already used as a biomarker for the presence of neurodegenerative diseases. Further applications of these findings could point to the use of 14-3-3 as a biomarker in testing for Parkinson's disease.


Contact: Mount Sinai Press Office
The Mount Sinai Hospital / Mount Sinai School of Medicine

Related medicine news :

1. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
2. Childhood obesity: Its not the amount of TV, its the number of junk food commercials
3. New York and Connecticut Drug Rehab Center Mountainside Weighs In on Latest White House Budget
4. Mountain Home 'Doing the Right Thing Really is the Best Business Approach'
5. Dominos Pizza(R) Raises Record Amount for St. Jude Childrens Research Hospital
6. Excitement Surrounding "Unveil Your Pink" Mounts!
7. Connecticut Governor Jodi Rell Honors Mountainside Addiction Treatment Center for its Twelve Years of Operating in Connecticut
8. Healthcare Trust of America, Inc. Executes Agreement to Acquire an Approximately 60,800 Square Foot Medical Office Building in Mount Pleasant, South Carolina
9. Mount Sinai researchers are the first to identify heart abnormalities in World Trade Center workers
10. Rutgers University Offers Fundamentals of Finance and Accounting Workshop at Mount Laurel, New Jersey Location Aimed at Non-Financial Managers
11. BOTOX Cosmetic & Wrinkle Filler Specialist Hosts Advanced Training Event at Ageless Beauty in Mountain Home, ID
Post Your Comments:
(Date:11/30/2015)... ... 01, 2015 , ... The National Association of Professional Women (NAPW) ... the Year Circle. She is recognized with this prestigious distinction for leadership in estate ... boasting more than 850,000 members and over 200 operating Local Chapters. , “I’m pleased ...
(Date:11/30/2015)... ... 30, 2015 , ... 1Heart Caregiver Services’ Executive Team actively ... Philippine American Chambers of Commerce held from November 6-8, 2015 at the Monte ... as an active delegate from the Philippine American Chamber of Commerce of Greater ...
(Date:11/30/2015)... ... November 30, 2015 , ... Being a caregiver for someone ... Maryland Health Care System, the Caregiver Support Program promotes the health and wellbeing ... job. Seventy-four percent report that their role as a caregiver has created marital ...
(Date:11/30/2015)... ... November 30, 2015 , ... During the National Family Caregivers ... held two webinars on topics of ‘Medical and Palliative Care Decisions,’ and ‘Self-Care ... . , With a loved one's diagnosis of mesothelioma, the closest family ...
(Date:11/30/2015)... ... November 30, 2015 , ... According to research by the ... dental technicians to be certified or obtain continuing education. To increase awareness of ... Your Mouth?” campaign to inform dentists that the technicians they trust could lack ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 30, 2015 ... adds a 2015 publication on ... 2015 with comprehensive analysis of recent ... deal types, such as Mergers & ... . --> ...
(Date:11/30/2015)... 30, 2015  The fee-for-service reimbursement model ... medical imaging is on its way to ... payer-provider contracts are set to phase out ... alter provider-vendor relationships. The shift to value-based, ... new purchasing frameworks in the medical imaging ...
(Date:11/30/2015)... MOUNTLAKE TERRACE, Wash. and ST. ... Cross and Express Scripts (NASDAQ: ESRX ) today ... benefit agreement. The partnership, which began in 1999, will ... --> --> After evaluating pharmacy ... process, Premera concluded that Express Scripts continues to offer ...
Breaking Medicine Technology: