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Mount Sinai Researchers Succeed in Programming Blood Forming Stem Cells
Date:6/13/2013

hn.mssm.edu/research/institutes/black-family-stem-cell-institute" onclick="linkClick(this.href)">The Black Family Stem Cell Institute at The Mount Sinai Medical Center.

“The combination of gene factors that we used was not composed entirely of the most obvious or expected proteins,” said Dr. Lemischka. “Many investigators have been trying to grow hematopoietic stem cells from embryonic stem cells, but this process has been problematic. Instead, we used mature mouse fibroblasts, picked the right combination of proteins, and it worked.”

“This discovery is just the beginning of something new and exciting and can hopefully be used to identify a treatment for blood disorders,” said Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean of the Icahn School of Medicine at Mount Sinai and Executive Vice President for Academic Affairs at The Mount Sinai Medical Center.

According to Dr. Pereira, there is a critical shortage of suitable donors for blood stem cell transplants. Donors are currently necessary to meet the needs of patients suffering from blood diseases such as leukemia, aplastic anemia, lymphomas, multiple myeloma and immune deficiency disorders. “Programming of hematopoietic stem cells represents an exciting alternative,” said Pereira.

“Dr. Lemischka and I have been working together for over 20 years in the fields of hematopoiesis and stem cell biology,” said Dr. Moore, senior author of the study. “It is truly exciting to be able to grow these blood forming cells in a culture dish and learn so much from them. We have already started applying this new approach to human cells and anticipate similar success.”

Mount Sinai Innovation Partners is managing the intellectual property for this cell replacement technology on behalf of the Mount Sinai researchers and is actively engaged with commercial collaboration opportunities.


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