Navigation Links
Mount Sinai Researchers Report Clinical Utility of Personalized Medicine Program for Cancer Patients
Date:6/1/2016

Scientists from the Icahn School of Medicine at Mount Sinai developed and tested a personalized cancer therapy program using an integrated genomic approach that led to therapeutic recommendations for 91 percent of patients. In a paper released today in Genome Medicine, they report results of the pilot program and show that multidimensional genomic profiles outperform the targeted cancer panels in use at many clinical labs today.

The genetic variants specific to a patient’s tumor are important for guiding the choice of cancer treatment. As DNA sequencing has become more affordable, clinical labs rapidly adopted targeted sequencing panels which scan tumor DNA for some variants known to cause cancer. In the personalized cancer therapy program at Mount Sinai, researchers generated much more data about the genetic makeup of both patients and their tumors to determine whether this in-depth characterization led to better results.

“There is tremendous interest in tailoring cancer treatment for each patient, since every tumor has its own unique signature of genetic variants that shape progression and response to therapy,” said senior author of the study Rong Chen, PhD, Assistant Professor of Genetics and Genomic Sciences and Director of Clinical Genome Informatics at the Icahn Institute at Mount Sinai. “We launched this program with the idea that a more comprehensive view of that variant signature would make a difference in patient treatment, but even we were surprised by just how much is being missed with current testing.”

The scientists analyzed whole exomes, gene expression, copy number variation, and gene fusions of both tumor samples and matched normal samples for an initial group of 46 patients. Participants had a wide range of cancer types — including colon, thyroid, and breast — and many were in advanced stages of the disease. In 42 of the 46 cases, the integrated genomic profile led to medically actionable genetic variants with implications about drug response, toxicity, or prognosis. The team also ran commercially available targeted cancer panels for each sample, finding that these tools failed to detect medically actionable variants for many patients. All results were returned to patients and their physicians, and in several cases the information led to changes in treatment.

“The argument against this integrated approach is the added cost of using multiple analysis platforms. But for patients battling cancer, it’s hard to put a price on information that may lead to more successful outcomes,” said Eric Schadt, PhD, the Jean C. and James W. Crystal Professor of Genomics at the Icahn School of Medicine at Mount Sinai, and Founding Director of the Icahn Institute for Genomics and Multiscale Biology. “We believe labs could maximize benefit by implementing a staggered approach, starting with targeted panels and incorporating multiscale characterization for patients lacking medically actionable variants.”

Paper cited:
Andrew V. Uzilov, Wei Ding, et al. Development and clinical application of an integrative genomic approach to personalized cancer therapy. Genome Medicine. DOI: 10.1186/s13073-016-0313-0

About the Icahn School of Medicine at Mount Sinai
The Icahn School of Medicine at Mount Sinai is an international leader in medical and scientific training, biomedical research, and patient care. It is the medical school for the Mount Sinai Health System, an integrated health care system which includes seven hospitals and an expanding ambulatory network serving approximately 4 million patients per year.

The School has more than 1,800 students in MD, PhD, and Master’s programs and post-doctoral fellowships; more than 5,600 faculty members; over 2,000 residents and fellows; and 23 clinical and research institutes and 34 academic departments. It is ranked among the highest in the nation in National Institutes of Health funding per principal investigator. The School was the first medical school in the country to create a progressive admissions approach for students who seek early assurance of admission through the FlexMed program.

The Graduate School of Biomedical Science trains PhD and MD/PhD students, and offers master’s-level programs in areas such as genetic counseling, clinical research, biomedical sciences, and public health, and an online master’s degree in health care delivery leadership. The seamless connections between our medical school, graduate school, and hospital campuses provide an extraordinary environment for translating scientific discoveries into clinical treatments.

For more information, visit http://icahn.mssm.edu or find the Icahn School of Medicine at Mount Sinai on Facebook, Twitter, YouTube, and LinkedIn.

# # #

Read the full story at http://www.prweb.com/releases/2016/06/prweb13456485.htm.


'/>"/>
Source: PRWeb
Copyright©2016 Vocus, Inc.
All rights reserved


Related medicine news :

1. National Association of Professional Women Announces Elizabeth C. Abel, M.S.W., Project Director, CAPP of City of Mount Vernon-Youth Bureau, as VIP Woman of the Year
2. Pradaxa Lawsuits Continue to Mount, With Filing of New Pradaxa Wrongful Death Claim in Pennsylvania by Wright & Schulte LLC
3. Mount Sinai Dermatology Department in NY Opens New Practice in Chinatown
4. Mount Sinai Makes Innovation a Team Effort At Its Second Annual Sinainnovations Conference, November 18-19, 2013 In NYC
5. Mount Sinai's Novel Gene Therapy Works to Reverse Heart Failure
6. Lipitor Lawsuits Continue to Mount, as Bernstein Liebhard LLP Notes Filing of New Claim Alleging an Association Between Lipitor and Diabetes
7. Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Mounting Claims Involving Risperdal Gynecomastia Allegations in Pennsylvania Litigation
8. Mount Sinais Arvin Dar, Ph.D., receives NIH New Innovator Award for drug development
9. Mirena Lawsuits Continue to Mount, As Bernstein Liebhard LLP Notes Filing of New Claim on Behalf of Alleged Victim of Mirena Complications
10. A Best Manuscript Award Goes to the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai
11. A Best Manuscript Award goes to Icahn School of Medicine at Mount Sinai
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2020)... (PRWEB) , ... August 05, 2020 , ... AdventHealth Carrollwood ... for safely reopening for class on Monday, August 12, 2020. AdventHealth provided the school ... spread of COVID-19 in the classroom setting. , “We are taking extra steps ...
(Date:8/5/2020)... , ... August 05, 2020 , ... CentrAlert, Inc. ... help everyone gain access to essential COVID-19 information. Know NOW!, which is available for ... COVID-19 updates and unify them in one easy-to-use mobile application. , “When COVID-19 first ...
(Date:8/3/2020)... ... August 03, 2020 , ... Evolution Labs announced today ... Prevention program district-wide, developed to help students navigate a range of issues related ... and districts must provide their students with preventative lessons after recent studies of ...
(Date:7/31/2020)... ... 2020 , ... Dentists Drs. Tye Thompson, Jordon Green, and ... for groundbreaking laser dentistry treatment whether or not they have a ... the many advantages of laser dentistry including less invasive treatment, fewer visits, and ...
(Date:7/22/2020)... ... July 22, 2020 , ... ... Lives Matter movement, the world has changed, and there’s no going back. In ... While coping mechanisms help us temporarily manage emotional struggles, healing is the approach ...
Breaking Medicine News(10 mins):
(Date:7/10/2020)... ... July 10, 2020 , ... Precision ... advanced manufacturing solutions provider today announced that their CANSWAB™ nasopharyngeal swabs are the ... has engineered a new 3D-printed swab design and has trademarked the name CANSWAB™ ...
(Date:7/10/2020)... ... ... The Urgent Care Association (UCA), College of Urgent Care Medicine (CUCM) and ... education on acute flaccid myelitis (AFM), an uncommon but serious condition that most commonly ... 14, 2020. , AFM, which is most prevalent in children, is a rapidly ...
(Date:7/7/2020)... ... 2020 , ... To support those on the front-lines of the Covid-19 pandemic, ... meals to the employees of Southern Nevada Health District. WGC Las Vegas will be ... July 8th. , When asked why the Women of Global Change felt it was ...
Breaking Medicine Technology: