Navigation Links
Mount Sinai Researchers Develop First Successful Laboratory Model for Studying Hepatitis C
Date:8/5/2013

New York, NY (PRWEB) August 05, 2013

By differentiating monkey stem cells into liver cells and inducing successful infection, researchers from the Icahn School of Medicine at Mount Sinai have shown for the first time that the hepatitis C virus (HCV) can replicate in monkeys, according to research published in the journal Gastroenterology. The new findings may lead to the first new animal model and provide new avenues for developing treatments and vaccines for this disease, which impacts more than three million people in the United States.

Scientists have tried for decades to develop animal models to study HCV, but the virus was incapable of infecting any species except for humans and chimpanzees. With a recent National Institutes of Health-imposed moratorium restricting chimpanzee research, the Mount Sinai research team turned to a close relative of chimpanzees and humans—macaques. Led by Matthew Evans, PhD, and Valerie Gouon-Evans, PhD, of Mount Sinai, the research team sought to find out why previous attempts to infect macaques with HCV failed.

Dr. Gouon-Evans, who is Assistant Professor of in the Department of Developmental and Regenerative Biology at Mount Sinai, worked with a team at the Fred Hutchison Cancer Research Center in Seattle to differentiate macaque stem cells into liver cells. Dr. Evans, who is an Assistant Professor in the Department of Microbiology, and his team then attempted to infect these cells with HCV in a petri dish. They found that these differentiated cells were able to support HCV infection and replication, although not as effectively as in human liver cells.

“Now that we know that HCV infection in macaque cells is possible, we wanted to find out why it only worked in liver cells that were derived from stem cells,” said Dr. Gouon-Evans. “By identifying where in the viral life cycle the infection is dysfunctional, we can develop an effective animal model of HCV.”

Dr. Evans and his team found that HCV was less efficient at entering macaque cells to initiate infection compared to human cells because changes in the macaque form of a certain cell surface receptor rendered it less functional than the human version. This cell entry block could be overcome by expressing the human version of this receptor in macaque cells. Furthermore, HCV infection of normal macaque cells was greatly enhanced by changes to the virus that loosened its requirements for that receptor.

“Our discovery shows that by manipulating either host or viral genetics we can efficiently infect macaque cells,” said Dr. Evans. “These findings may open doors for the field of HCV research, lead to new animal models, and hopefully vaccines and therapies.”

Next, Dr. Evans plans to take these experiments out of petri dishes by attempting to infect macaques in vivo with the mutant HCV that can use the receptors this animal naturally expresses. If successful, this work would provide a new, much-needed animal model for HCV studies and vaccine development.

This work was supported by the Pew Charitable Trust.

Read the full story at http://www.prweb.com/releases/2013/8/prweb10991135.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. David H. Koch donates $10 million to Mount Sinais Jaffe Food Allergy Institute
2. Great recession reflux amounts to more hunger among seniors
3. Mount Sinai presents treatment trends, vaccine research, prognosis data at ASCO
4. Mount Sinai researchers develop a multi-target approach to treating tumors
5. Mount Sinai is first in New York state to perform new Alzheimers imaging test in clinical setting
6. Limited amounts of alcohol during pregnancy do not harm children
7. Mount Sinai researcher finds timing of ADHD medication affect academic progress
8. Americans Already Consuming the Right Amount of Salt
9. Mount Sinai finds common factors in autism spectrum disorders, schizophrenia, and bipolar disorder
10. Be Present Welcomes Wanderlust Festival to Copper Mountain, Colorado
11. Is acetazolamide effective and safe for preventing acute mountain sickness?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... 24, 2017 , ... Mlynarek Insurance Agencies, a Detroit area ... owners across eastern Michigan, is connecting with the Oxford/Orion FISH Food Pantry for ... The Oxford/Orion FISH Food Pantry works to ensure homeless, hungry, and underprivileged families ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... that they are now offering treatments for sleep apnea and TMJ at their ... Sleep apnea , specifically the obstructive type, is increasingly being treated at ...
(Date:3/24/2017)... ... 2017 , ... Gastro Health (“GH”) ( http://www.gastrohealth.com ) ... colonoscopy at the HyGIeaCare® Center that is to be located adjacent to the ... The HyGIeaCare® Prep, cleared by the U.S. Food and Drug Administration (FDA), will ...
(Date:3/24/2017)... ... March 24, 2017 , ... “End Time GPS”: a dauntless and enlightened ... “End Time GPS” is the creation of published author, Wesley Gerboth, a World War ... munitions and space-vehicle projects. Now, at age ninety-one, he shares the Wisdom God bestowed ...
(Date:3/23/2017)... NC & Seattle, WA (PRWEB) , ... March 23, 2017 , ... ... public health emergency and now estimates that there could be four million Zika-related cases ... growing epidemics to date with numbers of US cases reported per year skyrocketing to ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... 24, 2017 The Board of Directors of ... Report 2016 including the complete 2016 Annual Accounts with notes. ... Nordic Nanovector,s website in the section Investor Relations/Reports and presentations/Annual ... ... Kvåle, Chief Financial Officer Cell: +47-91-51-95-76 Email: ir@nordicnanovector.com ...
(Date:3/23/2017)... 23, 2017  Transportation Insight, a multi-modal lead logistics ... chain management firm with expertise serving clients in the ... Rick Zaffarano was named a 2017 Food ... by the only publication exclusively dedicated to covering the ... "Rick has brought to Transportation Insight a ...
(Date:3/23/2017)... , March 23, 2017 ... Pharmaceutical and Healthcare disease pipeline guide Primary Hyperoxaluria ... of the Primary Hyperoxaluria (Genito Urinary System And ... a rare condition characterized by recurrent kidney and ... a substance called oxalate. Symptoms include blood in ...
Breaking Medicine Technology: