Navigation Links
Mount Sinai Researchers Develop First Successful Laboratory Model for Studying Hepatitis C
Date:8/5/2013

New York, NY (PRWEB) August 05, 2013

By differentiating monkey stem cells into liver cells and inducing successful infection, researchers from the Icahn School of Medicine at Mount Sinai have shown for the first time that the hepatitis C virus (HCV) can replicate in monkeys, according to research published in the journal Gastroenterology. The new findings may lead to the first new animal model and provide new avenues for developing treatments and vaccines for this disease, which impacts more than three million people in the United States.

Scientists have tried for decades to develop animal models to study HCV, but the virus was incapable of infecting any species except for humans and chimpanzees. With a recent National Institutes of Health-imposed moratorium restricting chimpanzee research, the Mount Sinai research team turned to a close relative of chimpanzees and humans—macaques. Led by Matthew Evans, PhD, and Valerie Gouon-Evans, PhD, of Mount Sinai, the research team sought to find out why previous attempts to infect macaques with HCV failed.

Dr. Gouon-Evans, who is Assistant Professor of in the Department of Developmental and Regenerative Biology at Mount Sinai, worked with a team at the Fred Hutchison Cancer Research Center in Seattle to differentiate macaque stem cells into liver cells. Dr. Evans, who is an Assistant Professor in the Department of Microbiology, and his team then attempted to infect these cells with HCV in a petri dish. They found that these differentiated cells were able to support HCV infection and replication, although not as effectively as in human liver cells.

“Now that we know that HCV infection in macaque cells is possible, we wanted to find out why it only worked in liver cells that were derived from stem cells,” said Dr. Gouon-Evans. “By identifying where in the viral life cycle the infection is dysfunctional, we can develop an effective animal model of HCV.”

Dr. Ev
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2

Related medicine news :

1. David H. Koch donates $10 million to Mount Sinais Jaffe Food Allergy Institute
2. Great recession reflux amounts to more hunger among seniors
3. Mount Sinai presents treatment trends, vaccine research, prognosis data at ASCO
4. Mount Sinai researchers develop a multi-target approach to treating tumors
5. Mount Sinai is first in New York state to perform new Alzheimers imaging test in clinical setting
6. Limited amounts of alcohol during pregnancy do not harm children
7. Mount Sinai researcher finds timing of ADHD medication affect academic progress
8. Americans Already Consuming the Right Amount of Salt
9. Mount Sinai finds common factors in autism spectrum disorders, schizophrenia, and bipolar disorder
10. Be Present Welcomes Wanderlust Festival to Copper Mountain, Colorado
11. Is acetazolamide effective and safe for preventing acute mountain sickness?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... GA (PRWEB) July 11, 2014 Datalogic ... step in improving sanitation hospital wide. With their new ... the spread of disease, like the devastating MRSA, which ... The Gryphon GD4400-HC 2D and the Gryphon ... 2D barcodes and can even read barcodes off of ...
(Date:7/11/2014)... -- U.S. health officials have concluded that it,s highly ... during a safety mishap last month. But, the ... announced a moratorium on the transfer of any dangerous ... a report issued Friday, the CDC outlined several measures ... incident doesn,t occur again. Last month, as many as ...
(Date:7/11/2014)... enterprises today are shifting towards the changing trend in ... offer these global enterprises a strategic method to cut ... operational costs to companies. The aim to minimize operational ... market driver for expanding the managed services market in ... estimated to grow from $142.75 billion in 2013 to ...
(Date:7/11/2014)... 10, 2014) Obese and overweight firefighters are ... care providers, according to new research from The ... (UTHealth). , National guidelines state that health care ... of maintaining a healthy weight. Firefighters have high ... leading cause of line-of-duty deaths in firefighters. This ...
(Date:7/11/2014)... 11, 2014 (HealthDay News) -- Prostate cancer patients are ... less effective treatment and die sooner if they also ... data from more than 41,200 American men who were ... They followed them through 2009. Nearly 1,900 of the ... years before their prostate cancer was discovered. "Men ...
Breaking Medicine News(10 mins):Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 2Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 3Health News:CDC Issues Tough Report on Anthrax Scare 2Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 4Health News:Depression May Make It Harder to Beat Prostate Cancer 2
... Germany and America who had treated injured protestors while ... to // leave Nepal by the King Gyanendra's government. ... detained Wednesday after he appeared on a private television ... brutally assaulted by the security forces. ,On ...
... at the McDonald’s or KFC restaurants, across the world, have ... levels of the same // food elsewhere. ,According to ... of Medicine, the researchers analysed various food items like McDonald's ... in many countries between 2004 and 2005, the Associated Press ...
... that been launched on a trial basis in Singapore would ... intensive care unit//. A camera hooked up beside the baby's ... to view the live footage on 3G-enabled mobile phones, Singapore ... on a three-month trial, during which the infants go online ...
... symposium titled ‘Challenging Intellectual Property’ will be analyzed and ... ,The Symposium will look into the aspects of ... production in economic development. It will also gauge the ... table, desirous of bringing a change in health research ...
... way to reverse the process of cell division. This ... could be an important milestone in the fight// against ... from the Oklahoma Medical Research Foundation have published their ... a million times in the human body each day. ...
... If you thought that McDonalds’ in USA serves the same ... and// think!,According to a study by three Danish doctors, fat ... as "trans fat" in foods purchased at McDonald's Corp and ... to the staggering research published in this week's New England ...
Cached Medicine News:
(Date:7/10/2014)... July 10, 2014  Breg, Inc., a premier ... launched the FreeRunner™ knee brace with new innovations ... patella mal-tracking return to active lifestyles.  FreeRunner,s patent-pending ... braces, providing support when patients need it most, ... don,t. Patellofemoral issues are the most ...
(Date:7/10/2014)...  Valeant Pharmaceuticals International, Inc. (NYSE: VRX ... the sale to Galderma of all rights to Restylane, ... Valeant for $1.4 billion in cash, pursuant to the ... its acquisition of Galderma. "We are ... a company that is firmly committed to the aesthetic ...
(Date:7/10/2014)... , July 10, 2014 Decision Resources ... awareness of the U.S. Food and Drug Administration,s (FDA) ... phosphate binder Velphoro, which was approved by the FDA ... chronic kidney disease (CKD) patients on dialysis. ... TreatmentTrends: Nephrology (US) Q2 2014 : ...
Breaking Medicine Technology:Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 3
... LAGUNA HILLS, Calif., Oct. 6 Minnow Medical, Inc., ... thermoplasty for the treatment of in-stent restenosis and other ... veteran medical device executives. Prabodh Mathur ... K. Handley has been named vice president of quality, ...
... Oct. 6 Ferring Pharmaceuticals Inc. today announced ... trials of LYSTEDA™ (tranexamic acid) tablets for cyclic ... of the peer-reviewed journal, Obstetrics & Gynecology ... significantly reduced menstrual blood loss from baseline, and ...
Cached Medicine Technology:Minnow Medical Bolsters Management Team 2Minnow Medical Bolsters Management Team 3Obstetrics and Gynecology Publishes Data From Pivotal Phase 3 LYSTEDA Study 2Obstetrics and Gynecology Publishes Data From Pivotal Phase 3 LYSTEDA Study 3Obstetrics and Gynecology Publishes Data From Pivotal Phase 3 LYSTEDA Study 4
Helmer's Horizon Series line of refrigerators are designed specifically for the cost conscious buyer. This line offers outstanding performance, quality, and the features you need to ensure the safety...
... presents i.Series refrigerators ... solutions for the blood ... features than ever before, ... are at the forefront ...
This storage freezer, which is based on our premium freezer line, maintain red cells safely below regulatory standards at -86C (-123F). Recorder is standard for model 8627. Model 8627 is UL Listed, C...
The TBR-360-1-GD is a large capacity upright style operating temperature +4C. It is specially designed refrigerators for the storage of blood in standard 500ml bags, complying with Australian Standar...
Medicine Products: