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Motor proteins may be vehicles for drug delivery
Date:3/20/2009

length of the tether and the communication between the motor domains could offer new targets for drugs that inhibit kinesins.

"There are a lot of kinesins involved in cell division, and cancer is uncontrolled cell division," said Hancock. "Our hope is that this knowledge will help in the design of new drugs that block the motors during cell division and thereby slow the growth of tumors."

The researchers also believe that the kinesin transport system could in the future be engineered onto microchips.

"Our idea is that you can hook up cargo -- drugs, antibodies, sequences of DNA or RNA -- and the motors would carry them through microchannels on a lab-on-a-chip type of device," added Hancock. "We have already had success with incorporating these proteins into microengineered channels and achieving transport in these systems."


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Contact: Amitabh Avasthi
aem1@psu.edu
814-865-9481
Penn State
Source:Eurekalert

Page: 1 2 3

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