Navigation Links
Mother's immunosuppressive medications not likely to put fetus at risk

Women with chronic autoimmune diseases who take immunosuppressive medications during their first trimester of pregnancy are not putting their babies at significantly increased risk of adverse outcomes, according to a Vanderbilt study released online by the journal Arthritis and Rheumatism.

The paper is one of the first to describe risks for medications used to treat autoimmune diseases when taken during pregnancy, according to first author William Cooper, M.D., MPH, Cornelius Vanderbilt Professor of Pediatrics and professor of Health Policy at Monroe Carell Jr. Children's Hospital at Vanderbilt in Nashville, Tenn.

"This study is important because these conditions affect nearly 4.5 million persons in the U.S., including many women of childbearing age," Cooper said. "Currently, there are almost no data to guide women who are pregnant, or planning to become pregnant, who may need to continue their medications during pregnancy."

Study authors used health plan data from Tennessee Medicaid, Kaiser Permanente Northern California and Southern California, linked with vital records and medical records. The three geographically diverse health plans collectively provide coverage for more than 8 million persons each year.

The cohort included 608 infants, including 437 with exposure during pregnancy and 171 whose mothers filled prescriptions for immunosuppressives before, but not during, pregnancy.

Women with rheumatoid and psoriatic arthritis, ankylosing spondylitis, lupus, scleroderma, and inflammatory bowel disease who filled prescriptions for immunosuppressive treatments during pregnancy were included in the study.

The drugs studied included hydroxychloroquine, tumor necrosis factor (TNF) inhibitors and other immunosuppressives such as sulfasalazine and azathioprine.

When compared with the women who had medication treatment before, but not during, pregnancy the risk ratios for adverse fetal outcomes associated with immunosuppressive use during pregnancy were not statistically significant, the authors reported.

Cooper said some of the medications in the study are relatively new and therefore haven't been extensively used in pregnancy. As use continues to expand, follow-up studies will be important to ensure that new safety signals aren't detected.

"One of the things we find in studying drug exposures in pregnancy is that, because up to 50 percent of pregnancies are unplanned, women may be taking a medication and become pregnant while still taking a potentially harmful drug," Cooper said. "Therefore, it's very important for women who have conditions that require medical treatments to talk with their providers about potential risks of medications in pregnancy."


Contact: Craig Boerner
Vanderbilt University Medical Center

Related medicine news :

1. Concerns about MRSA for expectant mothers may be unfounded
2. Low-Income Mothers May Overfeed Their Infants
3. Canadian teen moms run higher risk of abuse, depression than older mothers
4. Study finds that single mothers can reduce stress by playing, engaging with children
5. Study suggests poor mothers favor daughters
6. Making bad worse for expectant mothers
7. New hospital guidelines to help mothers at risk of postpartum depression
8. Lower iron levels seen in newborns of obese mothers
9. Babies Born to Obese Mothers May Have Low Iron: Study
10. Study Ties Infant Birth Weight to Mothers Breast Cancer Risk
11. Pregnant Mothers Gut Changes May Support Fetal Growth
Post Your Comments:
(Date:12/1/2015)... ... December 01, 2015 , ... SAN FRANCISCO, Calif. ... that the organization has awarded Education and Developmental Therapies (EDT), an Applied Behavior ... award celebrates exceptional special needs providers that excel in synthesizing the areas of ...
(Date:12/1/2015)... ... , ... Lutronic, a leading innovator of aesthetic and medical laser and energy-based ... sale in the United States. Clarity is a Superior Dual Wavelength Platform which ... a single platform that is easy to own and operate. , For over ...
(Date:12/1/2015)... ... December 01, 2015 , ... XTC Semifinals 2016 - ... to head to Las Vegas for CES 2016, the world’s largest Consumer Electronic Show, ... Technology Association Gary Shapiro, Founding Partner of Pacific Investments Veronica Serra, and venture capitalist ...
(Date:12/1/2015)... ... December 01, 2015 , ... Nurotron Biotechnology Co., Ltd., maker ... order to date. , The order will be from the China Disabled Persons’ ... Implant System is an effective solution for children and adults suffering from severe ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... Authorized Technology Provider (ATP) status from Cisco. This designation recognizes Tympani as having ... Unified Contact Center solutions targeted to the high-end enterprise contact center marketplace. , ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... a leader in intelligent sensors and analytic software for sensor network-based systems, announced the OS-3008 ... of vital signs. Photo - ... ... ... This ...
(Date:12/1/2015)... Dec. 1, 2015  ImmunoCellular Therapeutics, Ltd. ... Andrew Gengos , President and Chief Executive ... December 3, 2015. Mr. Gengos plans to ... program in patients with newly diagnosed glioblastoma ... TIME:    12:15p.m. ET/9:15a.m. PT LINK: ...
(Date:12/1/2015)... December 1, 2015 ... addition of the  "2016 Shigella Testing ... Technologies, Competitive Strategies, Emerging Opportunities--US, Europe ...  report to their offering. --> ... addition of the  "2016 Shigella Testing ...
Breaking Medicine Technology: