Navigation Links
Mother's immunosuppressive medications not likely to put fetus at risk
Date:11/8/2013

Women with chronic autoimmune diseases who take immunosuppressive medications during their first trimester of pregnancy are not putting their babies at significantly increased risk of adverse outcomes, according to a Vanderbilt study released online by the journal Arthritis and Rheumatism.

The paper is one of the first to describe risks for medications used to treat autoimmune diseases when taken during pregnancy, according to first author William Cooper, M.D., MPH, Cornelius Vanderbilt Professor of Pediatrics and professor of Health Policy at Monroe Carell Jr. Children's Hospital at Vanderbilt in Nashville, Tenn.

"This study is important because these conditions affect nearly 4.5 million persons in the U.S., including many women of childbearing age," Cooper said. "Currently, there are almost no data to guide women who are pregnant, or planning to become pregnant, who may need to continue their medications during pregnancy."

Study authors used health plan data from Tennessee Medicaid, Kaiser Permanente Northern California and Southern California, linked with vital records and medical records. The three geographically diverse health plans collectively provide coverage for more than 8 million persons each year.

The cohort included 608 infants, including 437 with exposure during pregnancy and 171 whose mothers filled prescriptions for immunosuppressives before, but not during, pregnancy.

Women with rheumatoid and psoriatic arthritis, ankylosing spondylitis, lupus, scleroderma, and inflammatory bowel disease who filled prescriptions for immunosuppressive treatments during pregnancy were included in the study.

The drugs studied included hydroxychloroquine, tumor necrosis factor (TNF) inhibitors and other immunosuppressives such as sulfasalazine and azathioprine.

When compared with the women who had medication treatment before, but not during, pregnancy the risk ratios for adverse fetal outcomes associated with immunosuppressive use during pregnancy were not statistically significant, the authors reported.

Cooper said some of the medications in the study are relatively new and therefore haven't been extensively used in pregnancy. As use continues to expand, follow-up studies will be important to ensure that new safety signals aren't detected.

"One of the things we find in studying drug exposures in pregnancy is that, because up to 50 percent of pregnancies are unplanned, women may be taking a medication and become pregnant while still taking a potentially harmful drug," Cooper said. "Therefore, it's very important for women who have conditions that require medical treatments to talk with their providers about potential risks of medications in pregnancy."


'/>"/>

Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Related medicine news :

1. Concerns about MRSA for expectant mothers may be unfounded
2. Low-Income Mothers May Overfeed Their Infants
3. Canadian teen moms run higher risk of abuse, depression than older mothers
4. Study finds that single mothers can reduce stress by playing, engaging with children
5. Study suggests poor mothers favor daughters
6. Making bad worse for expectant mothers
7. New hospital guidelines to help mothers at risk of postpartum depression
8. Lower iron levels seen in newborns of obese mothers
9. Babies Born to Obese Mothers May Have Low Iron: Study
10. Study Ties Infant Birth Weight to Mothers Breast Cancer Risk
11. Pregnant Mothers Gut Changes May Support Fetal Growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... HOUSTON, TEXAS (PRWEB) , ... May 31, 2016 ... ... is live in Greater Houston Healthconnect’s (Healthconnect) regional health information exchange, which enables ... prior medical records for their patients from other participating organizations in the exchange. ...
(Date:5/31/2016)... ... 31, 2016 , ... CallTrackingMetrics's software gives healthcare ... the performance of sales and support staff, and to efficiently route calls to ... customers to record, transcribe, route, document, and report on everything going on in ...
(Date:5/31/2016)... Miami, FL (PRWEB) , ... May 31, 2016 , ... ... the wellness industry, today released ten predictions on the future of wellness, travel, spa ... CEOs of top travel, spa and beauty companies to leading economists and researchers - ...
(Date:5/31/2016)... , ... May 31, 2016 , ... Interest is on ... screening tool and as an orthogonal tool for RNAi hit validation. A key reason ... specific guide RNAs—allows rapid generation of CRISPR RNA (crRNA) collections in arrayed formats. ...
(Date:5/31/2016)... Scotch Plains, NJ (PRWEB) , ... May 31, 2016 , ... ... University of Medicine and Dentistry of New Jersey in the class of 1986, where ... family and cosmetic dentistry at his current location in Livingston since 1989. He has ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... NESS ZIONA, Israel , ... a regenerative medicine company utilizing its proprietary plant-based rhCollagen ... has received authorization from the Chief Scientist of ... approximately 50% of its NIS 12 million development project ... million, measurably higher than last year,s authorized grant, which ...
(Date:5/30/2016)... York , May 30, 2016 ... report titled, "Advanced (3D/4D) Visualization Systems Market - Global ... - 2024." According to the report, the global advanced ... Bn in 2015 and is anticipated to expand at ... reach US$ 3.2 Bn in 2024. Advanced ...
(Date:5/30/2016)... 30, 2016 On 28 May, 194 ... by 2030. At the 69 th World Health Assembly, ... Hepatitis Strategy, signalling the greatest global commitment in viral hepatitis ... eliminating hepatitis B and C by 2030 and includes a ... reduce annual deaths by 65% and increase treatment to 80%, ...
Breaking Medicine Technology: