Navigation Links
Mother's flu during pregnancy may increase baby's risk of schizophrenia
Date:3/11/2010

CHAPEL HILL Rhesus monkey babies born to mothers who had the flu while pregnant had smaller brains and showed other brain changes similar to those observed in human patients with schizophrenia, a study at the University of Wisconsin-Madison in collaboration with the University of North Carolina at Chapel Hill has found.

The study, published online by the journal Biological Psychiatry, is the first study done with monkeys that examines the effects of flu during pregnancy. Results from this study support findings from rodent studies suggesting this type of infection may increase the risk of schizophrenia in the offspring, said lead author Sarah J. Short, Ph.D.

Short worked on the study while earning her doctorate at Wisconsin and now is a post-doctoral fellow at UNC working with John H. Gilmore, M.D., professor of psychiatry in the UNC School of Medicine.

"This was a relatively mild flu infection, but it had a significant effect on the brains of the babies," Short said. "While these results aren't directly applicable to humans, I do think they reinforce the idea, as recommended by the Centers for Disease Control and Prevention, that pregnant women should get flu shots, before they get sick."

In the study, 12 rhesus macaques were infected with a mild influenza A virus 1 month before their baby's due date, early in the third trimester of pregnancy. For comparison, the study also included 7 pregnant monkeys who did not have the flu.

When the babies were 1 year old, magnetic resonance imaging (MRI) scans were taken of their brains. Researchers also assessed the babies' behavioral development at that time.

The babies born to flu-infected mothers showed no evidence of direct viral exposure. Their birth weight, gestation length and neuromotor, behavioral and endocrine responses were all normal.

However, the MRI scans revealed significant reductions in overall brain size in the flu-exposed babies. In addition, the scans found significant reductions of "gray matter" (the portion of brain tissue that is dark in color) especially in areas of the brain called the cingulate and parietal lobe, and significant reductions of "white matter" (brain tissue that is lighter in color) in the parietal lobe.

The cingulate is located in the middle of the brain, but spans a broad distance from front to back and relays information from both halves of the brain. This structure is important for numerous cognitive function related to emotions, learning, memory, and executive control of these processes to aid in decision-making and anticipation of rewards. In addition this structure also plays a role in regulating autonomic processes, such as blood pressure and respiratory control. The parietal lobe comprises a large section on both sides of the brain between the frontal lobes and the occipital lobes, in the back of the brain. This part of the brain integrates information from all the senses and is especially important for combining visual and spatial information.

"The brain changes that we found in the monkey babies are similar to what we typically see in MRI scans of humans with schizophrenia," said Gilmore. "This suggests that human babies whose mothers had the flu while pregnant may have a greater risk of developing schizophrenia later in life than babies whose mothers did not have the flu. Normally that risk affects about 1 of every 100 births. Studies in humans suggest that for flu-exposed babies, the risk is 2 or 3 per 100 births."


'/>"/>

Contact: Tom Hughes
tahughes@unch.unc.edu
919-966-6047
University of North Carolina School of Medicine
Source:Eurekalert

Related medicine news :

1. California IVF Discount/Rebate Program Eases Risk for Older Mothers
2. Spanish-Speaking Mothers Less Likely to Turn on TV
3. Remuda Ranch, Programs for Eating and Anxiety Disorders, and MASK (Mothers Awareness on School-Age Kids), Partner to Help Educate Parents, Teachers and Students About Eating Disorders
4. The International Association of Pediatricians & Leading Physicians of the World Helps New Mothers Find Top Pediatricians in Their Area
5. March of Dimes Supports Urgent Needs of Mothers and Babies in Haiti Earthquake
6. Zambian study finds longer breastfeeding best for HIV-infected mothers
7. St. Louis Plastic Surgeon Renews Curves and Self-Esteem in New Mothers as Fresh Trends in Cosmetic Enhancement Emerge
8. Distrust of men doesnt stall low-income mothers romantic unions
9. Anthem Blue Cross and Blue Shield Offers Newborn and Parenting Resources to Ease New Mothers Transition Back to Work After Maternity Leave
10. WellPoints Affiliated Life and Disability Companies Offer Newborn and Parenting Resources to Ease New Mothers Transition Back to Work After Maternity Leave
11. Using science to save lives of mothers and children in Africa
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2017)... ... 14, 2017 , ... AgileMinder develops innovative products and services that bring "Care, ... available on Apple as a fun, free emoji sticker pack for iMessage. Use the ... ten color coded values on The Emoji Scale. , On Apple: "The Emoji ...
(Date:1/13/2017)... ... January 13, 2017 , ... ... sugar levels. Counting carbohydrates is as easy as checking the nutrition label on ... affects blood sugar levels. Despite being sugar-free, proteins can influence — either positively ...
(Date:1/13/2017)... , ... January 13, 2017 , ... A January 10 ... five procedures for 2017 according to the publication, with an emphasis on some new ... Jarrah-Nejad, M.D., F.I.C.S., F.A.C.S., who is known more casually to his patients and colleagues ...
(Date:1/13/2017)... (PRWEB) , ... January 13, 2017 , ... ... Moody Zook has taken on the challenge of providing additional organic alternatives for ... During the launch of the brand’s new line of all-natural activated charcoal products, ...
(Date:1/13/2017)... ... ... An inventor from Virginia Beach, Va., is always on the lookout for ... outfits, so he decided to design something that enhances the look of a belt, ... belt to allow for quick, easy changing of its look. This not only diversifies ...
Breaking Medicine News(10 mins):
(Date:1/12/2017)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), ... it has concluded agreements with the U.S. Department of ... (SEC) to resolve the previously disclosed U.S. Foreign Corrupt ... as in relation to the former deferred prosecution agreement ... with DOJ and SEC, respectively, on March 26, 2012.  ...
(Date:1/12/2017)... 2017  BioPharmX Corporation (NYSE MKT: BPMX), a specialty pharmaceutical ... findings at this week,s Orlando Dermatology Aesthetic & Clinical (ODAC) ... acnes -induced inflammation. The data will be shared ... Acne Pathogenesis," at ODAC, which is being held Jan. 13-16 ... ...
(Date:1/12/2017)... -- This new report from VPGMarketResearch contains 897 pages, ... German hospital microbiology testing market, including:  ... practice, as well as key economic, regulatory, demographic, social ... next ten years.  ... of major infectious diseases and microorganisms.  ...
Breaking Medicine Technology: