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Mother-daughter breast density study points way to earlier cancer risk assessment
Date:4/29/2009

void exposure to radiation from mammograms. Blood was obtained from each woman within 10 days of the start of the most recent menstrual period. Mothers underwent mammography and a random sample of 100 also consented to have a breast MRI.

Results show that percent breast water variation is higher in 15-19 year olds than in 20-30 year olds, and decreases with age, as backed by analysis of the 100 mother-daughter pairs who both had MRI.

The researchers found that in mothers, percent breast water as measured by MRI was strongly linked with percentage of mammographic density. Percent breast water in daughters (median 45%) was significantly higher than in mothers (28%), and decreases as their age and weight increases, but increases with increasing height. It was also linked to increasing MD in their mothers. Weight, height, and the mothers MD are known risk factors for breast cancer.

Higher blood growth hormone concentrations were also linked to higher percent breast water. Results showed that each 5cm difference in height in daughters was associated with 3% increase in percent breast water, which suggests a mechanism by which growth might affect the risk of cancer.


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Contact: Jane Finlayson
jane.finlayson@uhn.on.ca
416-946-2846
University Health Network
Source:Eurekalert

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