Navigation Links
Mother-daughter breast density study points way to earlier cancer risk assessment
Date:4/29/2009

(Toronto April 30, 2009) A unique mother-daughter study that used magnetic resonance to measure breast density in younger women shows that percent of breast water could be linked to the risk of breast cancer in middle age and older.

The findings, published online today in Lancet Oncology, add another key piece to the puzzle of understanding more about breast density, an inheritable characteristic known to be a cancer risk factor, that could aid in developing prevention methods, says principal investigator Dr. Norman Boyd, a scientist at The Campbell Family Institute for Breast Cancer Research at Princess Margaret Hospital.

Dr. Boyd initially verified breast density (mammographic density, or MD) as a strong risk factor for breast cancer in middle aged and older women in a landmark study published in the New England Journal of Medicine in 2007. Until now, little was known about the development of breast density in early life, or how it relates to a young woman's height, weight and age, and the breast density of their mothers.

The findings of the current study indicate that risk assessment using less harmful techniques such as magnetic resonance imaging (MRI) instead of X-ray should start much earlier in life.

Says Dr. Boyd: "It is known that the breast is most susceptible to the effects of carcinogens at early ages. Our findings suggest that differences in breast tissue composition in early life may be a potential mechanism for this increased susceptibility. By identifying the environmental and genetic factors that influence breast tissue composition in early life we may be able to develop safe and effective methods of prevention."

In this study, between 2003-2006, the researchers recruited 400 mother-daughter pairs and used MRI to examine breast tissue in daughters, aged 15-30-years, and a random sample of 100 of the mothers. In the young women, MRI was used to measure breast water concentration to avoid exposure to radiation from mammograms. Blood was obtained from each woman within 10 days of the start of the most recent menstrual period. Mothers underwent mammography and a random sample of 100 also consented to have a breast MRI.

Results show that percent breast water variation is higher in 15-19 year olds than in 20-30 year olds, and decreases with age, as backed by analysis of the 100 mother-daughter pairs who both had MRI.

The researchers found that in mothers, percent breast water as measured by MRI was strongly linked with percentage of mammographic density. Percent breast water in daughters (median 45%) was significantly higher than in mothers (28%), and decreases as their age and weight increases, but increases with increasing height. It was also linked to increasing MD in their mothers. Weight, height, and the mothers MD are known risk factors for breast cancer.

Higher blood growth hormone concentrations were also linked to higher percent breast water. Results showed that each 5cm difference in height in daughters was associated with 3% increase in percent breast water, which suggests a mechanism by which growth might affect the risk of cancer.


'/>"/>

Contact: Jane Finlayson
jane.finlayson@uhn.on.ca
416-946-2846
University Health Network
Source:Eurekalert

Related medicine news :

1. Medifast Announces Winners of Mother-Daughter Challenge
2. Mother-daughter conflict, low serotonin level may be deadly combination
3. Survival differences by race most apparent in advanced stages of breast cancer
4. MRI finds breast cancer before it becomes dangerous
5. Pathway links inflammation, angiogenesis and breast cancer
6. Drop in breast cancer incidence linked to hormone use, not mammograms
7. Breast cancer prevention practices vary across Canada
8. Eating junk food whilst pregnant and breastfeeding may lead to obese offspring
9. Acrylamide Wont Raise Breast Cancer Risk
10. New link between estrogen and breast cancer
11. Hypnosis Eases Pain of Breast Cancer Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Dickinson ... offers insurance and financial preparation services, is providing an update on a charitable ... , Rock City Rescue is a locally recognized nonprofit that provides shelter and ...
(Date:10/13/2017)... Nevada (PRWEB) , ... October 13, 2017 , ... ... Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil ... required and providing a CBD form that can be easily incorporated into liquid products, ...
(Date:10/13/2017)... , ... October 13, 2017 , ... The Visiting Nurse ... Market. Featuring a collection of specialty vendors and unique items from across the nation, ... quality-focused health and wellness services offered by the VNA. The boutique will be ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in agile ... a contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise ... use of Agile methodologies in a consistent and high value manner across CMS ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and fastest ... to open a flagship location in Covington, LA at 401 N. U.S. Highway 190, ... next to Office Depot in the Holiday Square shopping center. Its location allows it ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical Services, ... solutions for injectable drug administration, today shared the results ... Adapter for improving the intradermal administration of polio vaccines. ... Vaccination Summit in May 2017 by Dr. Ondrej ... Department, World Health Organization (WHO), and recently published in ...
(Date:10/4/2017)... , Oct. 4, 2017 ... single-use, self-contained, illuminating medical devices, today announced regulatory ... Health Surveillance Agency (or Agência Nacional de Vigilância ... first single-use, cordless surgical retractor with integrated LED ... optimal access, illumination and exposure of a tissue ...
(Date:10/2/2017)... The Rebound mobile app is poised to become a vital ... prescription drug addiction. The app empowers users to develop an ... their dosage in a safe, controlled manner while maximizing well-being. ... 100,000 people to sign up will enjoy 3 months of ... ...
Breaking Medicine Technology: