Navigation Links
Mother-daughter breast density study points way to earlier cancer risk assessment
Date:4/29/2009

(Toronto April 30, 2009) A unique mother-daughter study that used magnetic resonance to measure breast density in younger women shows that percent of breast water could be linked to the risk of breast cancer in middle age and older.

The findings, published online today in Lancet Oncology, add another key piece to the puzzle of understanding more about breast density, an inheritable characteristic known to be a cancer risk factor, that could aid in developing prevention methods, says principal investigator Dr. Norman Boyd, a scientist at The Campbell Family Institute for Breast Cancer Research at Princess Margaret Hospital.

Dr. Boyd initially verified breast density (mammographic density, or MD) as a strong risk factor for breast cancer in middle aged and older women in a landmark study published in the New England Journal of Medicine in 2007. Until now, little was known about the development of breast density in early life, or how it relates to a young woman's height, weight and age, and the breast density of their mothers.

The findings of the current study indicate that risk assessment using less harmful techniques such as magnetic resonance imaging (MRI) instead of X-ray should start much earlier in life.

Says Dr. Boyd: "It is known that the breast is most susceptible to the effects of carcinogens at early ages. Our findings suggest that differences in breast tissue composition in early life may be a potential mechanism for this increased susceptibility. By identifying the environmental and genetic factors that influence breast tissue composition in early life we may be able to develop safe and effective methods of prevention."

In this study, between 2003-2006, the researchers recruited 400 mother-daughter pairs and used MRI to examine breast tissue in daughters, aged 15-30-years, and a random sample of 100 of the mothers. In the young women, MRI was used to measure breast water concentration to avoid exposure to radiation from mammograms. Blood was obtained from each woman within 10 days of the start of the most recent menstrual period. Mothers underwent mammography and a random sample of 100 also consented to have a breast MRI.

Results show that percent breast water variation is higher in 15-19 year olds than in 20-30 year olds, and decreases with age, as backed by analysis of the 100 mother-daughter pairs who both had MRI.

The researchers found that in mothers, percent breast water as measured by MRI was strongly linked with percentage of mammographic density. Percent breast water in daughters (median 45%) was significantly higher than in mothers (28%), and decreases as their age and weight increases, but increases with increasing height. It was also linked to increasing MD in their mothers. Weight, height, and the mothers MD are known risk factors for breast cancer.

Higher blood growth hormone concentrations were also linked to higher percent breast water. Results showed that each 5cm difference in height in daughters was associated with 3% increase in percent breast water, which suggests a mechanism by which growth might affect the risk of cancer.


'/>"/>

Contact: Jane Finlayson
jane.finlayson@uhn.on.ca
416-946-2846
University Health Network
Source:Eurekalert

Related medicine news :

1. Medifast Announces Winners of Mother-Daughter Challenge
2. Mother-daughter conflict, low serotonin level may be deadly combination
3. Survival differences by race most apparent in advanced stages of breast cancer
4. MRI finds breast cancer before it becomes dangerous
5. Pathway links inflammation, angiogenesis and breast cancer
6. Drop in breast cancer incidence linked to hormone use, not mammograms
7. Breast cancer prevention practices vary across Canada
8. Eating junk food whilst pregnant and breastfeeding may lead to obese offspring
9. Acrylamide Wont Raise Breast Cancer Risk
10. New link between estrogen and breast cancer
11. Hypnosis Eases Pain of Breast Cancer Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... August 18, 2017 , ... August 18, 2017 — ... advocating for active, healthy lifestyles and highlighting the importance of proactive eye and ... impairments and shares the latest innovations in hearing aid technology. , According ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... The Dawn ... is inaugurating a new charity drive to generate community support for efforts to educate ... into cures and treatments for all types of cancer. , Each day in ...
(Date:8/18/2017)... ... August 18, 2017 , ... Moore Insurance, ... communities in east Texas, is launching a regional charity effort to provide publicity ... 1991, the Pediatric Brain Tumor Foundation (PBTF) has raised nearly $30 million in ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... planning firm that serves residential and commercial clients in the greater Houston region, ... raise community support for the fight against cancer. , Founded by Tony and ...
(Date:8/18/2017)... ... August 18, 2017 , ... With over ... in bioidentical hormone replacement therapy and integrative medicine, has become a frontrunner for ... aging, such as menopause, andropause, thyroid disorder and adrenal insufficiencies. , Founded ...
Breaking Medicine News(10 mins):
(Date:8/8/2017)... Second-quarter 2017 revenues of $876 ... from continuing operations Second-quarter ... $110 million Second-quarter 2017 ... Second-quarter 2017 adjusted diluted ... percent to $0.93 Second-quarter ...
(Date:8/7/2017)... Aug. 7, 2017  Endo International plc (NASDAQ: ... to resolve virtually all known U.S. mesh product liability ... resolve the known remaining U.S. claims at reasonable values. ... in the fourth quarter of 2017 and continuing through ... second quarter 2017 results, the Company intends to increase ...
(Date:8/2/2017)... BENTON, Ky. , Aug. 2, 2017   Marshall County Hospital in ... (ES) team to proactively reduce the risk of hospital-acquired infections (HAIs). The new addition, ... uses UVC light energy to kill deadly pathogens such as C. diff , MRSA, ... Tru-D SmartUVC ... Tru-D in action in a patient room ...
Breaking Medicine Technology: