Navigation Links
Mother-daughter breast density study points way to earlier cancer risk assessment

(Toronto April 30, 2009) A unique mother-daughter study that used magnetic resonance to measure breast density in younger women shows that percent of breast water could be linked to the risk of breast cancer in middle age and older.

The findings, published online today in Lancet Oncology, add another key piece to the puzzle of understanding more about breast density, an inheritable characteristic known to be a cancer risk factor, that could aid in developing prevention methods, says principal investigator Dr. Norman Boyd, a scientist at The Campbell Family Institute for Breast Cancer Research at Princess Margaret Hospital.

Dr. Boyd initially verified breast density (mammographic density, or MD) as a strong risk factor for breast cancer in middle aged and older women in a landmark study published in the New England Journal of Medicine in 2007. Until now, little was known about the development of breast density in early life, or how it relates to a young woman's height, weight and age, and the breast density of their mothers.

The findings of the current study indicate that risk assessment using less harmful techniques such as magnetic resonance imaging (MRI) instead of X-ray should start much earlier in life.

Says Dr. Boyd: "It is known that the breast is most susceptible to the effects of carcinogens at early ages. Our findings suggest that differences in breast tissue composition in early life may be a potential mechanism for this increased susceptibility. By identifying the environmental and genetic factors that influence breast tissue composition in early life we may be able to develop safe and effective methods of prevention."

In this study, between 2003-2006, the researchers recruited 400 mother-daughter pairs and used MRI to examine breast tissue in daughters, aged 15-30-years, and a random sample of 100 of the mothers. In the young women, MRI was used to measure breast water concentration to avoid exposure to radiation from mammograms. Blood was obtained from each woman within 10 days of the start of the most recent menstrual period. Mothers underwent mammography and a random sample of 100 also consented to have a breast MRI.

Results show that percent breast water variation is higher in 15-19 year olds than in 20-30 year olds, and decreases with age, as backed by analysis of the 100 mother-daughter pairs who both had MRI.

The researchers found that in mothers, percent breast water as measured by MRI was strongly linked with percentage of mammographic density. Percent breast water in daughters (median 45%) was significantly higher than in mothers (28%), and decreases as their age and weight increases, but increases with increasing height. It was also linked to increasing MD in their mothers. Weight, height, and the mothers MD are known risk factors for breast cancer.

Higher blood growth hormone concentrations were also linked to higher percent breast water. Results showed that each 5cm difference in height in daughters was associated with 3% increase in percent breast water, which suggests a mechanism by which growth might affect the risk of cancer.


Contact: Jane Finlayson
University Health Network

Related medicine news :

1. Medifast Announces Winners of Mother-Daughter Challenge
2. Mother-daughter conflict, low serotonin level may be deadly combination
3. Survival differences by race most apparent in advanced stages of breast cancer
4. MRI finds breast cancer before it becomes dangerous
5. Pathway links inflammation, angiogenesis and breast cancer
6. Drop in breast cancer incidence linked to hormone use, not mammograms
7. Breast cancer prevention practices vary across Canada
8. Eating junk food whilst pregnant and breastfeeding may lead to obese offspring
9. Acrylamide Wont Raise Breast Cancer Risk
10. New link between estrogen and breast cancer
11. Hypnosis Eases Pain of Breast Cancer Surgery
Post Your Comments:
(Date:11/25/2015)... ... 25, 2015 , ... On November 10, 2015, Bohrer Brady, LLC filed a ... behalf of a home health care worker who provided companionship services for the elderly, ... workers employed by Humana, Inc., Humana at Home, Inc., and SeniorBridge Family Companies (CT), ...
(Date:11/25/2015)... ... November 25, 2015 , ... According to an article published November ... more widely heralded as a breakthrough for performing hernia repairs. The article explains that ... surgery is that it can greatly reduce the pain that a patient might otherwise ...
(Date:11/25/2015)... OH (PRWEB) , ... November 25, 2015 , ... Dental ... implants in Cleveland, OH , are invited to attend Dr. Mark Iacobelli’s Advanced Implant ... this year in Cleveland, OH. , As the co-founders of Advanced Implant Mentoring ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... athletic programs, launches new Wimbledon Athletics Facebook page to educate the ... for unsuspected cardiac abnormalities. About 2,000 people under the age of 25 die ...
(Date:11/25/2015)... ... November 25, 2015 , ... On November 23rd 2015 Cozy Products, ... personal heating products business. Cozy Products explains what this means for business moving forward. ... with the Cozy Products business model: to sell personal heaters that reduce energy consumption, ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... PUNE, India , November 26, ... --> --> ... Research Report" and "Investigation Report on ... 2019 and 2021 forecasts data and ... library. . ...
(Date:11/26/2015)... , Nov. 26, 2015 Research ... addition of the "2016 Future Horizons and ... (TDM) Market: Supplier Shares, Country Segment Forecasts, Competitive ... --> --> ... analysis of the Italian therapeutic drug monitoring market, ...
(Date:11/26/2015)... , November 26, 2015 ... the addition of the  "2016 Future ... European Cell Surface Marker Testing Market: ...  report to their offering.  --> ... addition of the  "2016 Future Horizons ...
Breaking Medicine Technology: