Navigation Links
Most common brain cancer may start in neural stem cells
Date:6/2/2009

ANN ARBOR, Mich. University of Michigan scientists have found that a deficiency in a key tumor suppressor gene in the brain leads to the most common type of adult brain cancer. The study, conducted in mice that mimic human cancer, points the way to more effective future treatments and a way to screen for the disease early.

Appearing June 2 in Cancer Cell, the U-M team's findings in mice show for the first time that:

  • Glioblastoma, the type of cancer that afflicts U.S. Sen. Edward Kennedy and is diagnosed in about 10,000 Americans each year, may originate in neural stem cells located in a brain region known as the subventricular zone, or SVZ.
  • In mice, neural stem cells that normally live in this niche give rise to more specialized nerve cells that migrate out of the niche. Cancer could begin with a single genetic mutation in the p53 gene, which makes stem cells migrate out of the niche like their specialized progenies.

Much research on cancer has focused on the p53 gene, known as the "guardian of the genome" because it initiates a wave of other gene actions that normally thwart cancer.

Implications

The finding of a specific zone of origin could lead to treatments that may improve the dire median survival rate of 12 months for this type of brain cancer, says Yuan Zhu, Ph.D., the study's senior author and assistant professor in the departments of internal medicine and cell and developmental biology at the U-M Medical School.

"We have to pay more attention to the stem cell niche" in both early detection and treatment, says Zhu. If glioblastoma originates in neural stem cells in the subventricular zone in humans as it does in mice, the study suggests that doctors need to direct treatments there, as well as to the tumor, to eliminate the source of the cancer and keep it from returning, Zhu says.

The findings in mice also may lead in time to effective early screening tests for g
'/>"/>

Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Most common brain cancer may originate in neural stem cells
2. Bioniche Represented at House of Commons Sub-Committee on Food Safety
3. Common migraine pain condition also prevalent in cluster headache
4. WeissComm Group Acquires Common Sense Media Group, Appoints Founder Bob Pearson Chief Technology and Media Officer to Help Clients Evaluate and Optimize Social Media
5. Cogdell Spencer Announces Commencement of Common Stock Offering
6. Medivation Announces Offering of 2,750,000 Shares of Common Stock
7. Americans United for Life: Obama Nominates Avowed Judicial Activist Judge Who Undermines Common Ground
8. PET scan can non invasively measure early assessment of treatment for common type of breast cancer
9. Among Obese Diabetics, Sleep Apnea May Be Common
10. Gene Gives Clues to Why Autism More Common in Boys
11. Beckman Coulter, Inc. Announces Common Stock Offering
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... PA (PRWEB) January 22, 2015 Woodloch Pines, ... Mountains, has been selected by TripAdvisor as the number one ... the 6th best in the world for their annual Travelers’ ... online travel community . The website is home to millions ...
(Date:1/22/2015)... January 22, 2015 Padre Murphy's and Owner ... of Pro Player Health Alliance (PPHA). The PPHA's ... in getting everyone, including NFL greats, treated for obstructive sleep ... leading groups supporting the cause in the valley. The most ...
(Date:1/22/2015)... The Incredible Bulk is a revolutionary method ... lean muscle by up to 30lbs in less than 12 ... HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. , “Our ... scientific diet formula that allows the body to pack on ...
(Date:1/22/2015)... EAGAN, Minn. (PRWEB) January 22, 2015 Blue ... discover those Minnesotans who exemplify what it means to “Live ... a chance for people to share their stories about how ... adversity or simply inspired others by living in the moment. ...
(Date:1/22/2015)... The federal court overseeing thousands of vaginal ... Southern District of West Virginia has upheld a $2 million ... bellwether trial. In an Order dated January 21st, the Court ... that C.R. Bard had not proven a miscarriage of justice. ...
Breaking Medicine News(10 mins):Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4
... 11 The Substance Abuse and,Mental Health Services ... Survey on Drug Use and Health (NSDUH) indicate,3.1 ... to 25 have abused non-prescription,over-the- counter (OTC) cough ... once,in their lifetime. This announcement and the data ...
... announced,today that a new generic prescription drug program will ... drugstores., The program offers a 30-day supply of ... The medicines on the list include antibiotics and drugs,that ... digestive issues., There are no forms to fill ...
... system should fight tumors, researchers say , , FRIDAY, ... fight ovarian and breast cancer are in the ... safety and effectiveness, researchers report. , The vaccine ... an assistant professor at the University of Pennsylvania,s ...
... aging and the declining health,status of the 78 ... in the United States, U.S. Preventive Medicine, Inc. ... years ahead., "According to a recent Forrester ... include wellness and disease management,programs in their health ...
... the ... BOLINGBROOK, Ill., Jan. 11 The first new ... open its doors on Monday,January 14. After three years ... reviews from the Illinois,Department of Public Health and is ...
... to make sure people are adequately informed about the ... trial can be field-tested for effectiveness as vigorously as ... Johns Hopkins bioethicist suggests. , Informed consent, ... by which potential research subjects are asked to decide ...
Cached Medicine News:Health News:Statement of Steve Pasierb, President and CEO, Partnership for a Drug-Free America on New SAMHSA Study On Cough Medicine Abuse 2Health News:Statement of Steve Pasierb, President and CEO, Partnership for a Drug-Free America on New SAMHSA Study On Cough Medicine Abuse 3Health News:Statement of Steve Pasierb, President and CEO, Partnership for a Drug-Free America on New SAMHSA Study On Cough Medicine Abuse 4Health News:Hy-Vee Unveils New Generic Drug Program 2Health News:Vaccines for Ovarian and Breast Cancer in Early Trials 2Health News:Vaccines for Ovarian and Breast Cancer in Early Trials 3Health News:U.S. Preventive Medicine(R) Predicts Robust Growth Ahead 2Health News:Adventist Bolingbrook Hospital Opens to the Public 2Health News:Ways to improve informed consent are testable, study says 2
(Date:1/23/2015)... 23, 2015  Now available for sale, The Armor1 Ankle ... prevents ankle sprains by cushioning the ankle from an ... around the outside of any shoe type and allows ... still offering protection against sprains. With customers in physical ...
(Date:1/23/2015)... JUNCTION, N.J. , Jan. 23, 2015  CytoSorbents ... company commercializing its CytoSorb® extracorporeal cytokine adsorber to ... patients, announced the receipt of $385,642, net of ... participant of the Technology Business Tax Certificate Transfer ...
(Date:1/22/2015)... a privately held medical device company, announced today that ... ITOCHU Corporation (Tokyo Stock Exchange TYO: 8001) to sell ... cancer in Japan . ViewRay,s technology, ... only MRI-guided radiation therapy system that images and treats ...
Breaking Medicine Technology:The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2
... the C-terminal cleavage product produced during processing ... insulin molecule. Although the C-peptide of insulin ... liver or extra-renal metabolism and therefore has ... [1]. In addition, C-peptide assays may be ...
... C19 steroid, is one of the most ... males, testosterone is secreted primarily by the ... from peripheral conversion of androstenedione [2]. In ... over 50% of serum testosterone is derived ...
... Thyroid-stimulating hormone (TSH) is a 32 kDa ... the anterior pituitary gland [1]. The structure ... of the pituitary and placental gonadotropins, consisting ... identical between these hormones and a unique ...
... (T3) is produced primarily by 5-monodeioination of ... thyroid gland, T3 production occurs at a ... for T4. Release of T3 from the ... micrograms/day as compared to 80-100 micrograms/day for ...
Medicine Products: