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Most Newer Antipsychotics No Better Than Older Ones, Just Different
Date:12/5/2008

lth, believes efforts are needed to find ways to tell which patients will respond to which of the many drugs available.

"Neither class of drugs is homogenous," Insel said. "There is not a huge difference between the classes when you look at efficacy. Where the differences emerge is largely with side effects."

"It would be wonderful," he added, "if we could know how to predict which patient is going to respond to which medication, but we don't know that yet. But we do know that just because somebody doesn't respond to the first one doesn't mean they are not going to respond to the next one."

Finding "biomarkers" that would predict which drug will work for a given patient is going to be the focus of new research, Insel said. "We really need to get serious about personalized medicine for psychiatric illnesses," he said.

More information

To learn more about antipsychotic drugs, visit the U.S. National Institute of Mental Health.



SOURCES: John Davis, M.D., research professor, psychiatry, University of Illinois at Chicago; Peter Tyrer, M.D., Department of Psychological Medicine, Imperial College London, England; Thomas R. Insel, M.D., director, U.S. National Institute of Mental Health, Bethesda, Md.; Dec. 5, 2008, The Lancet, online


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