Navigation Links
Most Childhood Cancer Survivors Have Healthy Babies
Date:10/6/2009

But pregnancies should be closely monitored, researchers say

TUESDAY, Oct. 6 (HealthDay News) -- Most female and male childhood cancer survivors have normal pregnancies and healthy children, according to two U.S. studies.

Treatments -- chemotherapy, radiation and surgery -- that save the lives of children with cancer may affect their future reproductive health. As the number of childhood cancer survivors increases, it's becoming increasingly important to identify possible problems, including the effects on their babies, the study authors pointed out.

In one study, researchers looked at 1,898 infants born to women diagnosed with cancer before they were 20 and compared them with 14,278 infants born to women who didn't have childhood cancer.

Infants born to the childhood cancer survivors weren't at increased risk for birth defects or death, but were 54 percent more likely to be born preterm and 31 percent more likely to weigh less than 2,500 grams (5.5 pounds) at birth. However, the infants weren't at increased risk for being small for gestational age, the study authors noted.

The researchers also studied infant outcomes by type of mother's cancer and treatments.

"Risk of preterm delivery was greatest after leukemia but also was associated with lymphoma, bone tumors, soft-tissue sarcomas and an abdominal primary cancer site. Among treatment exposures, chemotherapy was associated with a twofold increased risk of preterm delivery, but relative risks were significantly increased for most other modalities as well," wrote Beth A. Mueller, of the Fred Hutchinson Cancer Research Center and the University of Washington in Seattle, and colleagues.

Rates of diabetes, preeclampsia and anemia during pregnancy were similar in both groups of women. But diabetes was more common among bone cancer survivors; anemia among brain tumor survivors and those treated with chemotherapy; and preeclampsia among those treated with a combination of chemotherapy, surgery and radiation.

"Children and adolescents with cancer can be reassured that we did not find an increased risk of malformations or infant death among their first subsequent offspring," the researchers concluded. "The increased occurrence of low birth weight and preterm delivery among childhood cancer survivors and of preterm delivery among young genital tract carcinoma survivors that we and others have observed may indicate relatively less severe potential problems among offspring. However, these outcomes can still greatly affect families, are associated with significantly increased costs and indicate a need for close monitoring of pregnancies among childhood and adolescent cancer survivors."

The study appears in the October issue of the journal Archives of Pediatrics & Adolescent Medicine.

Another study in the same issue of the journal looked at 470 children of men who had childhood cancer and found that the infants had a "borderline risk" of weighing less than 2,500 grams at birth, especially if their father had cancer at an early age or underwent chemotherapy.

"However, they were not at risk of being born prematurely, being small for gestational age, having malformations or having an altered male to female ratio," wrote Dr. Eric J. Chow, of the Fred Hutchinson Cancer Research Center, and colleagues.

In general, female partners of male childhood cancer survivors weren't at increased risk for pregnancy complications, the study found. However, women did have a higher risk of preeclampsia if their male partner had certain types of childhood cancer, especially brain tumors.

"Most pregnancies resulting in live births among partners of male childhood cancer survivors were not at significantly greater risk of complications versus comparison subjects. However, our findings of increased low birth weight and preeclampsia associated with some diagnostic groups raises the possibility that prior cancer therapy may affect male germ cells (cells that will become sperm) with effects on female partners and progeny of male survivors," the study authors concluded.

More information

The Nemours Foundation has more about childhood cancer.



-- Robert Preidt



SOURCE: JAMA/Archives journals, news release, Oct. 5, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Pediatrics: Doctors Must Find Better Ways to Talk To Parents about Childhood Obesity
2. Daily Candy in Childhood Linked to Violence in Adulthood
3. Studies find few risks to newborn offspring of parents who are childhood cancer survivors
4. Training clinicians helps reduce rates of early childhood cavities
5. Northern California Cancer Center Finds Increased Risk of Most Common Form of Childhood Leukemia Associated With Residential Proximity to Agricultural Pesticides
6. Childhood Stroke More Common Than Thought
7. Presentation at Annual Meeting Highlights Increased Risk of Heart Failure in Childhood Cancer Survivors
8. Treating Childhood Leukemia With Fewer Side Effects
9. Video: U.S. Department of Health and Human Services Joins Ad Council and Warner Bros. Pictures to Combat Childhood Overweight and Obesity
10. COSHAR Foundation Promotes Importance of Timely Childhood Immunization at Black Family Reunion Celebration in Washington, D.C.
11. Doctors Efforts to Fight Childhood Obesity Not Working
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... December 07, 2016 , ... "Today, MHA ... most comprehensive mental health systems reform legislation in more than fifty years. We ... the commitment of our elected officials to improving mental health services and supports ...
(Date:12/7/2016)... ... December 07, 2016 , ... Silhouette Instalift is a simple, ... and tightening the skin of the face to create more youthful features. While ... very little downtime, Silhouette Instalift is a novel, minimally invasive facial procedure that ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... a purchase price of approximately $17.4 million (net of the cash acquired), ... approximately $13.2 million. Headquartered in Barcelona, Spain, Presence is a leading provider ...
(Date:12/7/2016)... Valley, CA (PRWEB) , ... December 07, 2016 , ... ... be used in several ways to restore a more youthful appearance to the face. ... now offer Sculptra, along with a variety of other treatments, to rejuvenate and renew ...
(Date:12/7/2016)... , ... December 07, 2016 , ... They are musicians ... sisters and wives, brothers and fathers, from New England and around the nation. What ... stigma, and are brought together in a beautiful and compelling new photographic exhibit debuting ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016 Henry Schein, Inc. ... health care products and services to office-based dental, animal health ... percent equity investment in Marrodent, one of Poland,s ... approximately $32 million. This transaction was announced on August 30, ... in Poland since 2014, and Marrodent ...
(Date:12/8/2016)... Research and Markets has announced the addition of ... their offering. ... The report provides separate comprehensive analytics for the ... Rest of World. Annual estimates and forecasts are provided ... provided for these markets. Market data and analytics are derived from primary ...
(Date:12/7/2016)... , Dec. 7, 2016 "Lantus (Insulin Glargine) Biosimilar Clinical ... on 37 biosimilar version of Lantus drug in clinical pipeline. Currently 5 ... , Japan , Kenya , ... Germany , China , Slovakia ... 1 & 2 diabetes mellitus. The patent on Lantus expired in 2014. ...
Breaking Medicine Technology: