Navigation Links
Most Breast Tumors Have Unique Genetic 'Fingerprint,' Study Finds
Date:4/2/2011

SATURDAY, April 2 (HealthDay News) -- Researchers who sequenced the entire genomes of tumors from 50 breast cancer patients identified more than 1,700 mutations, most of which were unique to individual patients.

The findings help explain why it's difficult to predict breast cancer patient outcomes and to find new treatments, said the researchers at Washington University in St. Louis and the Siteman Cancer Center.

After sequencing the tumor genomes, the researchers compared the sequences to the matched DNA of the same patients' healthy cells, which allowed them to find the mutations. They also sequenced the 10 trillion chemical bases of DNA more than 30 times to ensure the data was accurate.

All the patients in the study had estrogen-receptor-positive breast cancer, in which cancer cells have receptors that bind to estrogen and help the tumors grow. The study will be presented Saturday at the American Association for Cancer Research (AACR) annual meeting in Orlando, Fla.

Some genetic mutations that are rare in breast cancer are common in other cancers and there may be drugs available to treat them, lead investigator Dr. Matthew Ellis, a professor of medicine at Washington University School of Medicine in St. Louis, said in an AACR news release.

However, treatment is only possible when the cancer's genetics are known beforehand. The ideal goal is to be able to design treatments by sequencing the tumor genome when a patient's cancer is first diagnosed, Ellis said.

He and the other researchers found two common mutations previously found in breast cancer patients, as well as three new ones that occured in an average of one in 10 women. However, "to get through this experiment and find only three additional gene mutations at the 10 percent recurrence level was a bit of a shock," he said.

In addition, the researchers found 21 other mutations that appeared at much lower rates in several patients. Even though these mutations were relatively rare, Ellis emphasized the finding's value. "Breast cancer is so common that mutations that recur at a 5 percent frequency level still involve many thousands of women," he said.

"We get good therapeutic ideas from the genomic information," he added. "The near term goal is to use information on whole genome sequencing to guide a personalized approach to the patient's treatment."

Because the study is being presented at a medical meeting, the findings should be considered preliminary until published in a peer-reviewed journal.

More information

The U.S. National Cancer Institute has more about breast cancer.

-- Robert Preidt

SOURCE: American Association of Cancer Research, news release, April 2, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
2. Low forms of cyclin E reduce breast cancer drugs effectiveness
3. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
4. For Some Breast Cancer Patients, Shorter Radiation Works Well
5. Short-term radiation therapy successful on breast cancer
6. Few Women at High Risk for Breast Cancer Take Tamoxifen
7. Hormone May Prevent Aggressive Breast Cancer
8. MSU researcher linking breast cancer patients with alternative therapies
9. MRI May Not Add Value to Routine Breast Cancer Care
10. Breast Cancer Stats Differ Racially Despite Similar Mammogram Rates
11. Businesses Rally Big Efforts to Benefit the Susan G. Komen Phoenix Affiliates Fight Against Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Most Breast Tumors Have Unique Genetic 'Fingerprint,' Study Finds
(Date:10/12/2017)... ... ... Planet Fitness, one of the largest and fastest growing franchisors and operators ... location in Covington, LA at 401 N. U.S. Highway 190, in January of 2018. ... in the Holiday Square shopping center. Its location allows it to serve both Covington ...
(Date:10/12/2017)... ... 12, 2017 , ... The American College of Medical Informatics (ACMI) will present ... the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... Collen, a pioneer in the field of medical informatics, this prestigious award is presented ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... Restoration, has recently contributed a medical article to the newly revamped Cosmetic ... Mohebi’s article spotlights the hair transplant procedure known as Follicular Unit Extraction ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the Health & ... by Moonlight to raise money for the American Heart Association Heart Walk. Teams of ... will work together to keep their treadmills moving for 5 hours. Treadmills will start ...
(Date:10/12/2017)... BALTIMORE (PRWEB) , ... October 12, 2017 , ... ... average of $3,296 in property taxes a year. In some states—like New York, ... higher. , By contrast, many overseas retirement havens have extremely low property-tax rates, ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... , Sept. 27, 2017  Commended for their devotion ... notable awards. Ranked as number one in the South Florida ... time in Inc. 5000 yearly list, the national specialty pharmacy ... Armando Bardisa will soon be honored by SFBJ ... Set to receive his award in ...
(Date:9/25/2017)...   Montrium , an industry leader in ... IQPC Trial Master Files & Inspection Readiness Conference ... Clinical Services has selected eTMF Connect ... EastHORN, a leading European contract research organization (CRO), ... to enable greater collaboration with sponsors, improve compliance ...
(Date:9/23/2017)... , Sept. 22, 2017 Janssen Biotech, Inc. ... response letter from the U.S. Food and Drug Administration ... of sirukumab for the treatment of moderately to severely ... additional clinical data are needed to further evaluate the ... severely active RA. ...
Breaking Medicine Technology: