Navigation Links
Most Antidepressants Miss Key Target of Clinical Depression
Date:12/10/2009

Brain Not Healed After Six Weeks of Antidepressants - Don't Stop Treatment Too Early

TORONTO, Dec. 10 /PRNewswire/ - People often feel well after six weeks of antidepressants but a new study published in the Archives of General Psychiatry shows why it is hazardous to stop treatment at this point.

A key brain protein called monoamine oxidase A (MAO-A) is highly elevated during clinical depression and does not normalize after six weeks of treatment with commonly used antidepressants called SSRIs (serotonin reuptake inhibitors).

This is not the time to stop taking the antidepressant because MAO-A digests brain chemicals including serotonin, that help maintain healthy mood. High MAO-A levels remove too much serotonin.

The study also showed that when people are not taking antidepressants, high levels of MAO-A lead to getting ill again.

According to Dr. Jeffrey Meyer, the lead investigator, "Since most antidepressants do not target MAO-A, we have to wait for the brain to heal this process. The future is to make treatments that tell the brain to make less MAO-A so as to shorten the period of time antidepressants are needed. In the meantime it is important to follow standard recommendations of continuing treatment for at least a minimum of six months to a year."

Researchers at the Centre for Addiction and Mental Health used an advanced brain imaging method to measure levels of the brain protein MAO-A. VP of Research Bruce Pollock highlights the study's use of complex technology, "CAMH has the only positron emission tomography (PET) centre in the world that is dedicated solely to mental health and addiction treatment and research. As a result, we were able to develop this new technology to measure MAO-A levels."

Dr. Meyer is the Head of Neurochemical Imaging Program in Mood Disorders, and a Canada Research Chair in the Neurochemistry of Depression.

The study (Brain Monoamine Oxidase A Binding in Depressive Disorder: Relationship to Selective Serotonin Reuptake Inhibitor Treatment, Recovery, and Recurrence) was funded by the Canadian Institutes of Health Research, the Ontario Mental Health Foundation, and the Canadian Foundation for Innovation. The Centre for Addiction and Mental Health (CAMH) is Canada's largest mental health and addiction teaching hospital. CAMH combines clinical care, research, education, policy, development, prevention and health promotion to transform the lives of people affected by mental health and addiction issues.

SOURCE CAMH Foundation


'/>"/>
SOURCE CAMH Foundation
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Antidepressants May Change Your Personality
2. Why antidepressants dont work for so many
3. Antidepressants May Be Linked to Birth Problems
4. Antidepressants Linked to Heart Defects in Newborns
5. Antidepressants: Benefit of SNRI is proven
6. Suicide Risk With Antidepressants Falls With Age
7. Almost 1 quarter of Spanish women take antidepressants
8. Antidepressants aid electroconvulsive therapy in treating severe depression
9. Preliminary report on antidepressants published
10. Some Antidepressants May Thwart Tamoxifens Effect on Breast Cancer
11. Are we cherry picking participants for studies of antidepressants?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2016)... ... May 06, 2016 , ... A wide variety of national pet product manufacturers, companies and ... Safety Media Showcase Wednesday, May 18 from noon to 8 p.m. at New York City’s ... at new and established home, garden, outdoor and safety pet products in today’s marketplace. ...
(Date:5/6/2016)... ... May 06, 2016 , ... Online HR/benefits platforms offer a range of ... for traditional brokers and health plans. “ The Rapid Emergence of Online Benefits Firms: ... Information Services, Inc. (AIS), will offer an accurate picture of online benefits today, and ...
(Date:5/6/2016)... ... May 06, 2016 , ... Expert ... . , Since launching in September, 2014 Sleepopolis has resided at Sleepopolis-mattress-reviews.com ... now include pillows, sheets, mattress toppers, bed frames, and more. , Founder and ...
(Date:5/6/2016)... ... May 06, 2016 , ... This Mother’s Day kicks ... everywhere. The 17th annual National Women’s Health Week takes place May 8-May ... Health are combining forces to empower women to make their health a top priority. ...
(Date:5/5/2016)... ... 05, 2016 , ... While the practice and profession of Aging Life Care ... population has on communities and resources. Aging Life Care plays an important role as ... , Aging Life Care is a holistic, client-centered approach to caring for older ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... , May 4, 2016 ... of the  "Global Acute lymphocytic Leukemia Market ... to their offering.       (Logo: ... Acute Lymphocytic Leukemia Market and Competitive Landscape ... Lymphocytic Leukemia pipeline products, Acute Lymphocytic Leukemia ...
(Date:5/3/2016)... DUBLIN , May 4, 2016 ... the "Global Cancer Stem Cell Therapy Market Outlook ... (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,Recombinant technology has ... therapeutics are expected to be developed in coming years. ... these techniques. Cancer stem cell therapies are also expected ...
(Date:5/3/2016)... , May 3, 2016 ACME ... Whelan and Delaware County Councilman ... Nasal Spray in all ACME pharmacies across ... for Disease Control and Prevention (CDC), naloxone has saved 26,463 lives ... officers in Delaware County were authorized to ...
Breaking Medicine Technology: