Navigation Links
Most Antidepressants Miss Key Target of Clinical Depression
Date:12/10/2009

Brain Not Healed After Six Weeks of Antidepressants - Don't Stop Treatment Too Early

TORONTO, Dec. 10 /PRNewswire/ - People often feel well after six weeks of antidepressants but a new study published in the Archives of General Psychiatry shows why it is hazardous to stop treatment at this point.

A key brain protein called monoamine oxidase A (MAO-A) is highly elevated during clinical depression and does not normalize after six weeks of treatment with commonly used antidepressants called SSRIs (serotonin reuptake inhibitors).

This is not the time to stop taking the antidepressant because MAO-A digests brain chemicals including serotonin, that help maintain healthy mood. High MAO-A levels remove too much serotonin.

The study also showed that when people are not taking antidepressants, high levels of MAO-A lead to getting ill again.

According to Dr. Jeffrey Meyer, the lead investigator, "Since most antidepressants do not target MAO-A, we have to wait for the brain to heal this process. The future is to make treatments that tell the brain to make less MAO-A so as to shorten the period of time antidepressants are needed. In the meantime it is important to follow standard recommendations of continuing treatment for at least a minimum of six months to a year."

Researchers at the Centre for Addiction and Mental Health used an advanced brain imaging method to measure levels of the brain protein MAO-A. VP of Research Bruce Pollock highlights the study's use of complex technology, "CAMH has the only positron emission tomography (PET) centre in the world that is dedicated solely to mental health and addiction treatment and research. As a result, we were able to develop this new technology to measure MAO-A levels."

Dr. Meyer is the Head of Neurochemical Imaging Program in Mood Disorders, and a Canada Research Chair in the Neurochemistry of Depression.

The study (Brain Monoamine Oxidase A Binding in Depressive Disorder: Relationship to Selective Serotonin Reuptake Inhibitor Treatment, Recovery, and Recurrence) was funded by the Canadian Institutes of Health Research, the Ontario Mental Health Foundation, and the Canadian Foundation for Innovation. The Centre for Addiction and Mental Health (CAMH) is Canada's largest mental health and addiction teaching hospital. CAMH combines clinical care, research, education, policy, development, prevention and health promotion to transform the lives of people affected by mental health and addiction issues.

SOURCE CAMH Foundation


'/>"/>
SOURCE CAMH Foundation
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Antidepressants May Change Your Personality
2. Why antidepressants dont work for so many
3. Antidepressants May Be Linked to Birth Problems
4. Antidepressants Linked to Heart Defects in Newborns
5. Antidepressants: Benefit of SNRI is proven
6. Suicide Risk With Antidepressants Falls With Age
7. Almost 1 quarter of Spanish women take antidepressants
8. Antidepressants aid electroconvulsive therapy in treating severe depression
9. Preliminary report on antidepressants published
10. Some Antidepressants May Thwart Tamoxifens Effect on Breast Cancer
11. Are we cherry picking participants for studies of antidepressants?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the ... Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , “We ... new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin ... injury. Recently, he has implemented orthobiologic procedures as a method for treating his ... of the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of ... of the latter, setting the bar too high can result in disappointment, perhaps even ... progress toward their goal. , Research from PsychTests.com reveals that behind ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced ... feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as a ... has released tools for healthy coping following a traumatic event. , Trauma sufferers tend ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, ... at his family verbally and physically. , “When something upset him, he couldn’t control his ... it. He would throw rocks at my other children and say he was going to ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... 23, 2016 Any dentist who has made an ... current process. Many of them do not even offer this ... and high laboratory costs involved. And those who ARE able ... such a high cost that the majority of today,s patients ... Parsa Zadeh , founder of Dental Evolutions Inc. and ...
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: RO, ... clearance for its Elecsys BRAHMS PCT (procalcitonin) assay as ... or septic shock. With this clearance, Roche is the ... fully integrated solution for sepsis risk assessment and management. ... bacterial infection and PCT levels in blood can aid ...
Breaking Medicine Technology: