Navigation Links
Most Antidepressants Miss Key Target of Clinical Depression
Date:12/10/2009

Brain Not Healed After Six Weeks of Antidepressants - Don't Stop Treatment Too Early

TORONTO, Dec. 10 /PRNewswire/ - People often feel well after six weeks of antidepressants but a new study published in the Archives of General Psychiatry shows why it is hazardous to stop treatment at this point.

A key brain protein called monoamine oxidase A (MAO-A) is highly elevated during clinical depression and does not normalize after six weeks of treatment with commonly used antidepressants called SSRIs (serotonin reuptake inhibitors).

This is not the time to stop taking the antidepressant because MAO-A digests brain chemicals including serotonin, that help maintain healthy mood. High MAO-A levels remove too much serotonin.

The study also showed that when people are not taking antidepressants, high levels of MAO-A lead to getting ill again.

According to Dr. Jeffrey Meyer, the lead investigator, "Since most antidepressants do not target MAO-A, we have to wait for the brain to heal this process. The future is to make treatments that tell the brain to make less MAO-A so as to shorten the period of time antidepressants are needed. In the meantime it is important to follow standard recommendations of continuing treatment for at least a minimum of six months to a year."

Researchers at the Centre for Addiction and Mental Health used an advanced brain imaging method to measure levels of the brain protein MAO-A. VP of Research Bruce Pollock highlights the study's use of complex technology, "CAMH has the only positron emission tomography (PET) centre in the world that is dedicated solely to mental health and addiction treatment and research. As a result, we were able to develop this new technology to measure MAO-A levels."

Dr. Meyer is the Head of Neurochemical Imaging Program in Mood Disorders, and a Canada Research Chair in the Neurochemistry of Depression.

The study (Brain Monoamine Oxidase A Binding in Depressive Disorder: Relationship to Selective Serotonin Reuptake Inhibitor Treatment, Recovery, and Recurrence) was funded by the Canadian Institutes of Health Research, the Ontario Mental Health Foundation, and the Canadian Foundation for Innovation. The Centre for Addiction and Mental Health (CAMH) is Canada's largest mental health and addiction teaching hospital. CAMH combines clinical care, research, education, policy, development, prevention and health promotion to transform the lives of people affected by mental health and addiction issues.

SOURCE CAMH Foundation


'/>"/>
SOURCE CAMH Foundation
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Antidepressants May Change Your Personality
2. Why antidepressants dont work for so many
3. Antidepressants May Be Linked to Birth Problems
4. Antidepressants Linked to Heart Defects in Newborns
5. Antidepressants: Benefit of SNRI is proven
6. Suicide Risk With Antidepressants Falls With Age
7. Almost 1 quarter of Spanish women take antidepressants
8. Antidepressants aid electroconvulsive therapy in treating severe depression
9. Preliminary report on antidepressants published
10. Some Antidepressants May Thwart Tamoxifens Effect on Breast Cancer
11. Are we cherry picking participants for studies of antidepressants?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... communities in the greater Dallas, Miami, and Raleigh regions, is organizing an extended ... overcome a rare and deadly chromosome abnormality. , After struggling since birth with ...
(Date:10/13/2017)... Pekin, IL (PRWEB) , ... October 13, 2017 ... ... Foundation, which established the certification process to promote standards of excellence for the ... iaedp™ Symposium, scheduled for March 22 – 25, 2018 in Orlando, Florida at ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term ... long-term care insurance companies have a waiver for care if the client has a ... when the family pays for care, is often waived, so the benefits from their ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor ... on sciatica in a new episode of "Success Files," which is an award-winning ... innovation and investigates each subject in-depth with passion and integrity. , Sciatica occurs ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco dentists, ... cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated to ... breathing. Oral appliances can offer significant relief to about 75 percent of people ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Oct. 12, 2017   Divoti USA will ... to the standard of the latest FDA requirements, which stipulates new ... Anyone in need of Medical ID jewelry such as Medical ... are engraved in terms of the new FDA requirements ... Divoti offers this dark ...
(Date:10/11/2017)... 2017  Caris Life Sciences ® , a leading ... of precision medicine, today announced that St. Jude Medical ... Alliance™ (POA) as its 17 th member. Through ... Crosson Cancer Institute will help develop standards of care ... profiling, making cancer treatment more precise and effective. ...
(Date:10/10/2017)... COUNTY, Calif. , Oct. 10, 2017  NDS received FDA ... Mobile  — a medical-grade battery-powered display stand specifically designed for endoscopy ... to transform technology into a clinical solution to support the improvement ... Innovative Design ... ZeroWire Mobile Wireless Solution ...
Breaking Medicine Technology: