Navigation Links
Most Antidepressants Miss Key Target of Clinical Depression
Date:12/10/2009

Brain Not Healed After Six Weeks of Antidepressants - Don't Stop Treatment Too Early

TORONTO, Dec. 10 /PRNewswire/ - People often feel well after six weeks of antidepressants but a new study published in the Archives of General Psychiatry shows why it is hazardous to stop treatment at this point.

A key brain protein called monoamine oxidase A (MAO-A) is highly elevated during clinical depression and does not normalize after six weeks of treatment with commonly used antidepressants called SSRIs (serotonin reuptake inhibitors).

This is not the time to stop taking the antidepressant because MAO-A digests brain chemicals including serotonin, that help maintain healthy mood. High MAO-A levels remove too much serotonin.

The study also showed that when people are not taking antidepressants, high levels of MAO-A lead to getting ill again.

According to Dr. Jeffrey Meyer, the lead investigator, "Since most antidepressants do not target MAO-A, we have to wait for the brain to heal this process. The future is to make treatments that tell the brain to make less MAO-A so as to shorten the period of time antidepressants are needed. In the meantime it is important to follow standard recommendations of continuing treatment for at least a minimum of six months to a year."

Researchers at the Centre for Addiction and Mental Health used an advanced brain imaging method to measure levels of the brain protein MAO-A. VP of Research Bruce Pollock highlights the study's use of complex technology, "CAMH has the only positron emission tomography (PET) centre in the world that is dedicated solely to mental health and addiction treatment and research. As a result, we were able to develop this new technology to measure MAO-A levels."

Dr. Meyer is the Head of Neurochemical Imaging Program in Mood Disorders, and a Canada Research Chair in the Neurochemistry of Depression.

The study (Brain Monoamine Oxidase A Binding in Depressive Disorder: Relationship to Selective Serotonin Reuptake Inhibitor Treatment, Recovery, and Recurrence) was funded by the Canadian Institutes of Health Research, the Ontario Mental Health Foundation, and the Canadian Foundation for Innovation. The Centre for Addiction and Mental Health (CAMH) is Canada's largest mental health and addiction teaching hospital. CAMH combines clinical care, research, education, policy, development, prevention and health promotion to transform the lives of people affected by mental health and addiction issues.

SOURCE CAMH Foundation


'/>"/>
SOURCE CAMH Foundation
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Antidepressants May Change Your Personality
2. Why antidepressants dont work for so many
3. Antidepressants May Be Linked to Birth Problems
4. Antidepressants Linked to Heart Defects in Newborns
5. Antidepressants: Benefit of SNRI is proven
6. Suicide Risk With Antidepressants Falls With Age
7. Almost 1 quarter of Spanish women take antidepressants
8. Antidepressants aid electroconvulsive therapy in treating severe depression
9. Preliminary report on antidepressants published
10. Some Antidepressants May Thwart Tamoxifens Effect on Breast Cancer
11. Are we cherry picking participants for studies of antidepressants?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Carolina (PRWEB) , ... June 26, 2016 , ... ... of a new product that was developed to enhance the health of felines. The ... centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... 2016 , ... Experts from the American Institutes for Research ... June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR experts ... planning, healthcare costs and patient and family engagement. , AIR researchers will be ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX ... Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over ... Cut Pro X . Simply select a ProHand generator and drag it above media ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... ... , ... A recent article published June 14 on E Online ... on to state that individuals are now more comfortable seeking to undergo not only ... calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... has announced the addition of the " Global ... This report ... provides an updated review, including its applications in various ... total market, which includes three main industries: pharmaceutical and ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June ... -based mobile pulmonary function testing company, is now able to ... devices developed by ndd Medical Technologies , Inc. ... done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ... , can get any needed testing done in the comfort of ...
(Date:6/24/2016)... , June 24, 2016 ... appointment of Dr. Edward Futcher to ... Director, effective June 23, 2016.Dr. Futcher was also ... and Governance Committees.  As a non-executive member of ... expertise and strategic counsel to VolitionRx in connection ...
Breaking Medicine Technology: