Navigation Links
Mosquito mating mechanism could lead to new attack on dengue and yellow fever
Date:4/10/2008

Cornell researchers have identified a mating mechanism that possibly could be adapted to prevent female mosquitoes from spreading the viruses that cause dengue fever, second only to malaria as the most virulent mosquito-borne disease in the tropical world.

Specifically, they have discovered 63 proteins that male mosquitoes transfer to Aedes aegypti females during mating and are thought briefly to change the females' physiology and behavior, in particular suppressing the female's appetite for mammalian blood.

In a study published in the journal Insect Biochemistry and Molecular Biology, the Cornell researchers report that the proteins in the seminal fluid of the males also trigger a loss of sexual appetite in the females, stimulate egg production and influence clotting of the blood she has ingested.

The findings could lead to novel strategies to prevent the spread of dengue as well as mosquito-borne yellow fever viruses. "This is a new angle in our fight against vector-borne disease," said Laura Harrington, Cornell associate professor of entomology and the paper's senior author.

Dengue affects 50 million people annually, and two-thirds of the world's population is at risk. In the past year, it has reached epidemic levels in Asia, South and Central America and Mexico, where the number of dengue cases has increased by more than 300 percent from a year earlier. No dengue vaccine is available, and no treatment exists beyond supportive care.

Laura Sirot, a postdoctoral researcher in molecular biology and genetics, is the paper's lead author, and Mariana Wolfner, Cornell professor of molecular biology and genetics, also is a co-author. The work builds on Wolfner's work on the reproductive biology of fruit flies.

The next step, said Harrington, is to isolate, identify and verify the targets of the mosquito proteins that regulate such key post-mating behaviors as reduced sexual drive or lack of appetite for blood; also, to manipulate such physiological responses as increased egg production. Eventually, the researchers hope that this knowledge will lead to new ways to control mosquitoes that spread disease. This could involve the identification of highly specific chemicals that affect these newly discovered reproductive proteins, or potentially could inform experiments on the use of genetically modified mosquitoes with knocked out (or turned off) genes or modified reproductive behaviors.


'/>"/>

Contact: Blaine Friedlander
bpf2@cornell.edu
607-254-8093
Cornell University Communications
Source:Eurekalert

Related medicine news :

1. Fort Dodges Mosquito Shot Offers Convenient Protection Against Dangerous Mosquito-Borne Illnesses
2. Free distribution of insecticide-treated mosquito nets can save lives
3. Study garners unique mating photos of wild gorillas
4. Researchers Define Mechanism of Methamphetamine Addiction
5. Study identifies mechanism underlying multidrug resistance in fungi
6. Increased hepcidin expression: A novel oncogenic signalling mechanism
7. Researchers describe mechanisms by which capon gene causes heart rhythm disturbances
8. Novel mechanism found that may boost impaired function of leukemia protein
9. Mechanism of blood clot elasticity revealed in high definition
10. Who found some new mechanisms of HBV virulence?
11. Japan Backs Away from Making Real Changes to Its Rx Pharma Pricing Mechanism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... (PRWEB) , ... August 22, 2017 , ... ... luxurious collection of unique masks and serums that perfectly fuse the beauty of ... advancements, at the 2017 Indie Beauty Expo on August 23rd & 24th in ...
(Date:8/22/2017)... ... 2017 , ... The old adage “you are what you ... healthy foods. But this well-known piece of nutrition advice ignores that an individual’s ... not only on properties of the food but also on properties of the ...
(Date:8/22/2017)... , ... August 22, 2017 , ... ... pleased to announce the addition of Zack Tisch as the firm’s new Consulting ... KLAS-ranked healthcare IT consulting firm’s national accounts, from assisting clients with initial vendor ...
(Date:8/22/2017)... CA (PRWEB) , ... August 22, 2017 , ... ... cycle management (RCM) solutions, announced recently the availability of a new professional fee ... in appreciation for their service to the healthcare industry. E/M coding is complex ...
(Date:8/22/2017)... DFW Metroplex, TX (PRWEB) , ... August 22, 2017 , ... Five Star Glass is ... They provide repair and replacement of auto glass for most makes and models, in ... area in the USA. , They have been a family owned business for the ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... , Aug. 3, 2017  Agragen, LLC, ... company active in the biopharmaceutical, nutraceutical, and aquacultural ... development of its lead drug candidates, AGR131.  This ... proinflammatory cytokine from the blood of patients suffering ... and inflammatory bowel disease. ...
(Date:8/2/2017)... -- CaryRx, a next-generation full-service pharmacy, has announced the launch ... the Washington D.C. metropolitan area. CaryRx ... of medications through the convenience of its patient-friendly mobile app. ... one hour to any location in D.C. ... service to Washington D.C. ," says Areo ...
(Date:7/28/2017)... CHICAGO, July 28, 2017 Hill-Rom Holdings, Inc. ... fiscal third quarter ended June 30, 2017, and updated ... For the fiscal third quarter, ... to $0.68 per diluted share in the prior-year period. ... of $0.39 per diluted share primarily related to the ...
Breaking Medicine Technology: