Navigation Links
Mosquito mating mechanism could lead to new attack on dengue and yellow fever
Date:4/10/2008

Cornell researchers have identified a mating mechanism that possibly could be adapted to prevent female mosquitoes from spreading the viruses that cause dengue fever, second only to malaria as the most virulent mosquito-borne disease in the tropical world.

Specifically, they have discovered 63 proteins that male mosquitoes transfer to Aedes aegypti females during mating and are thought briefly to change the females' physiology and behavior, in particular suppressing the female's appetite for mammalian blood.

In a study published in the journal Insect Biochemistry and Molecular Biology, the Cornell researchers report that the proteins in the seminal fluid of the males also trigger a loss of sexual appetite in the females, stimulate egg production and influence clotting of the blood she has ingested.

The findings could lead to novel strategies to prevent the spread of dengue as well as mosquito-borne yellow fever viruses. "This is a new angle in our fight against vector-borne disease," said Laura Harrington, Cornell associate professor of entomology and the paper's senior author.

Dengue affects 50 million people annually, and two-thirds of the world's population is at risk. In the past year, it has reached epidemic levels in Asia, South and Central America and Mexico, where the number of dengue cases has increased by more than 300 percent from a year earlier. No dengue vaccine is available, and no treatment exists beyond supportive care.

Laura Sirot, a postdoctoral researcher in molecular biology and genetics, is the paper's lead author, and Mariana Wolfner, Cornell professor of molecular biology and genetics, also is a co-author. The work builds on Wolfner's work on the reproductive biology of fruit flies.

The next step, said Harrington, is to isolate, identify and verify the targets of the mosquito proteins that regulate such key post-mating behaviors as reduced sexual drive or lack of appetite for blood; also, to manipulate such physiological responses as increased egg production. Eventually, the researchers hope that this knowledge will lead to new ways to control mosquitoes that spread disease. This could involve the identification of highly specific chemicals that affect these newly discovered reproductive proteins, or potentially could inform experiments on the use of genetically modified mosquitoes with knocked out (or turned off) genes or modified reproductive behaviors.


'/>"/>

Contact: Blaine Friedlander
bpf2@cornell.edu
607-254-8093
Cornell University Communications
Source:Eurekalert

Related medicine news :

1. Fort Dodges Mosquito Shot Offers Convenient Protection Against Dangerous Mosquito-Borne Illnesses
2. Free distribution of insecticide-treated mosquito nets can save lives
3. Study garners unique mating photos of wild gorillas
4. Researchers Define Mechanism of Methamphetamine Addiction
5. Study identifies mechanism underlying multidrug resistance in fungi
6. Increased hepcidin expression: A novel oncogenic signalling mechanism
7. Researchers describe mechanisms by which capon gene causes heart rhythm disturbances
8. Novel mechanism found that may boost impaired function of leukemia protein
9. Mechanism of blood clot elasticity revealed in high definition
10. Who found some new mechanisms of HBV virulence?
11. Japan Backs Away from Making Real Changes to Its Rx Pharma Pricing Mechanism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... ... The University of Iowa, long recognized as one of the top research ... teachers with the specific skills and training they need to teach English as a ... and HigherEducation.com is working to ensure that this new program is available to the ...
(Date:1/24/2017)... CA (PRWEB) , ... January 24, 2017 , ... The ... good news for everyone and particularly good news for prostate cancer patients: incidents of ... diagnosis. , According to the report the cancer death rate has dropped from its ...
(Date:1/24/2017)... Pass, OR (PRWEB) , ... January 24, 2017 ... ... Gerald H. Pollack, Ph.D., http://www.faculty.washington.edu/ghp , Sharon Kleyne, the nation’s foremost ... of Water, Global Climate Change and Your Health on Voice America, once again ...
(Date:1/24/2017)... ... January 24, 2017 , ... ... unveiled its latest award-winning bottles, designed specifically to optimize the drinking experience for ... Agua is renowned for introducing the world’s first untouched bottled water purposed exclusively ...
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... ... a leading natural supplement for relieving premenstrual syndrome, or PMS . , ... some point. These symptoms can include cramps, constipation, irritability, headaches, fatigue, and other ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... PUNE, India , January 24, 2017 ... Allied Market Research, titled, "Cold Chain Logistics Market by ... & Frozen Dessert, Meat, Fish & Sea Food, Drugs ... Industry Forecasts, 2014-2022," projects that the global cold chain ... 2022, growing at a CAGR of 16% (2016 to ...
(Date:1/24/2017)... January 24, 2017 Analysis of the Liquid ... Liquid Biopsies - our new study reveals trends, R&D progress, ... If you are involved in this sector you must read this ... revenues streams to 2027, assessing data, trends, opportunities and business prospects ... Discover How ...
(Date:1/24/2017)... GAITHERSBURG, Md. , Jan. 24, 2017 /PRNewswire/ ... leader in the engineering and industrialization of biology to improve ... announced that it has entered into a definitive agreement to ... a clinical-stage company and pioneer in the development of AdenoVerse™ ... and expand upon GenVec,s expertise in adenoviral vectors and cGMP ...
Breaking Medicine Technology: