Navigation Links
Morria Biopharmaceuticals Plc Announces Preliminary Results Regarding Inflammatory Markers From its Phase II Study in Allergic Rhinitis
Date:10/29/2008

LONDON, Oct. 29 /PRNewswire/ -- Morria Biopharmaceuticals Plc, a biopharmaceutical company focused on the development of novel, anti-inflammatory drugs, announced today the preliminary results from its recently completed Phase II equivalent study of MRX-4, in a nasal aerosol formulation, in 105 patients suffering from allergic rhinitis (AR). The two-arm, randomized, multi-dose, double-blind, placebo-controlled study included Rhinocort(R) as the steroid comparator arm.

A secondary efficacy endpoint of this study was the effect of MRX-4 on inflammatory mediators/markers in the nasal lavage of selected patients following allergen stimulus. The patients were pre-treated by either a placebo or MRX-4 for 7 days twice per day (b.i.d.) beforehand.

MRX-4 demonstrates an overall trend of reducing the levels of five inflammatory mediators: IL-5 (interleukin-5), IL-13, TNF-alpha (Tumor Necrosis Factor alpha), MCP-1 (Monocyte Chemoattractant Protein-1) and Eotoxin. These mediators have been shown to play an important role in various inflammatory diseases such as allergic rhinitis, asthma, skin and intestinal inflammation and arthritis. All have previously been shown to be modulated by MRX-4 in vitro and in vivo in pre-clinical models. This is the first time that such modulation has been observed in patients.

In addition, the levels of eosinophils were tested in the nasal lavage. Eosinophils are white blood cells that play a key role in the allergic response. MRX-4 reduced the levels of these cells compared to placebo-treated patients.

"We are pleased by the wide range of divergent inflammatory mediators that we are modulating, several of which have been extensively covered in the scientific literature recently. Mediators, such as IL-5, IL-13 and TNF-alpha, are currently targets of research and development in the pharmaceutical field for treating respiratory inflammatory diseases, and MRX-4 modulates them in these patients," said Yuval Cohen, Pr
'/>"/>

SOURCE Morria Biopharmaceuticals Plc
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine news :

1. Presentation Time Correction: Keryx Biopharmaceuticals Presents at 12:00pm, ET Tomorrow (Oct. 3) at William Blair & Company Small-Cap Growth Stock Conference
2. Nabi Biopharmaceuticals Announces Third Quarter 2007 Financial Results and Positive Vote from November 8, 2007 Special Stockholders Meeting
3. Nabi Biopharmaceuticals Completes Sale of Nabi Biologics to Biotest AG
4. Keryx Biopharmaceuticals, Inc. Announces Poster Presentations Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) to be Presented at the Upcoming American Society of Hematology Meeting in Atlanta, Georgia
5. XTL Biopharmaceuticals Announces Financial Results for the Year Ended December 31, 2007
6. Keryx Biopharmaceuticals, Inc. Announces Second Quarter 2008 Financial Results
7. HHS Announces $75 Million in Supplemental Funding to States for Pandemic Flu Preparedness
8. CRC Health Group Announces Acquisition of Bayside Marin Recovery Center, San Rafael
9. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
10. HEI, Inc. Announces Sale of RFID Division Assets
11. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Zyloprim(R)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... If you have asthma, you may have an asthma ... recognize and respond to changes and understand when symptoms are ... green zone, you,re doing well, yellow means your asthma has ... urgent care. New guidelines are now available to help your ... green and away from the red zone. , "Management of ...
(Date:7/31/2014)... July 31, 2014 Developer Jamestown, L.P., ... on its Ponce City Market project in Atlanta’s Old ... Roebuck & Company building into best-in-class office, housing, and ... reviewed Jamestown’s experience with their construction webcam service to ... Jamestown wanted a construction camera for monitoring ...
(Date:7/31/2014)... Hoping to attract new customers who are looking for a ... ready to ship out free samples of product. A form ... offer fast and easy: http://www.nutrigold.com/Free-Samples , According to ... know that every time customers purchase one of our products, ... own health or the health of a loved one and ...
(Date:7/31/2014)... Ce-Classes.com has announced that they are ... professionals, a Systematic Review of Sexual Satisfaction . ... the International Journal of Clinical and Health Psychology. , ... a need to have accurate information about sexual satisfaction ... possible. The material provides a systematic review of ...
(Date:7/31/2014)... 2014 Dr. Stewart Shofner of ... first surgeons in the United States to successfully treat glaucoma ... smallest medical device ever approved by the FDA. Dr. ... the benefits of using a procedure known as Selective Laser ... and his colleagues now recognize that this procedure is a ...
Breaking Medicine News(10 mins):Health News:OxBlue Construction Webcam Proves Valuable Tool for Developer, Consumers on Historic Ponce City Market Project 2Health News:OxBlue Construction Webcam Proves Valuable Tool for Developer, Consumers on Historic Ponce City Market Project 3Health News:NutriGold Launches Product Samples Page for its Supplements 2Health News:NutriGold Launches Product Samples Page for its Supplements 3Health News:Company Provides New Course on Sexual Satisfaction 2Health News:Company Provides New Course on Sexual Satisfaction 3Health News:Nashville’s Top Eye Surgeon, Dr. Stewart Shofner Successfully Treats Glaucoma Patients Using a Procedure Known as Selective Laser Trabeculoplasty (SLT) 2Health News:Nashville’s Top Eye Surgeon, Dr. Stewart Shofner Successfully Treats Glaucoma Patients Using a Procedure Known as Selective Laser Trabeculoplasty (SLT) 3Health News:Nashville’s Top Eye Surgeon, Dr. Stewart Shofner Successfully Treats Glaucoma Patients Using a Procedure Known as Selective Laser Trabeculoplasty (SLT) 4
... Mass. (February 10, 2008) Unlike the rest of the ... That quirk dates back to the time when mammals began ... have red cells that contain nuclei that are inactive. Losing ... oxygen-carrying hemoglobin, thus enabling more oxygen to be transported in ...
... pose deadly burden , , SUNDAY, Feb. 10 (HealthDay News) ... doctors have long been familiar with this curious but ... there,s a greater likelihood that the surviving spouse will ... better understanding of the forces at work, realizing problems ...
... in the Government ... AIDS System, NEW ... its strong support for a Global,Fund to Fight AIDS, Tuberculosis and Malaria ... (WB) concerning,the second phase of National AIDS Control Programme (NACO) projects,implemented throughout ...
... Day - What better Valentine,s Day gift than the,"gift ... Saturn,retailers nationwide have held more than 1,900 community donor ... local blood center partners,as part of Saturn National Donor ... the launch will be hosted by,Cavender,s Saturn of San ...
... Antidepressant medications,which increase serotonin neurotransmitter levels can ... depression, impulsivity and,suicide risk in depressed patients, ... serotonin enhancement medications to dopamine,deficient patients, patients ... Dr. Rick Sponaugle, Medical Director of Florida ...
... ev3 Inc. (Nasdaq:,EVVV), a global endovascular device company, today ... as Chief Scientist and,from the company,s board of directors ... years, few people have shaped the treatment of,cardiovascular disease ... and vision for improving the lives of patients worldwide," ...
Cached Medicine News:Health News:How red blood cells nuke their nuclei 2Health News:Spouse's Sickness Bodes Ill for Partner's Health 2Health News:Spouse's Sickness Bodes Ill for Partner's Health 3Health News:AIDS Healthcare Foundation Shares World Bank, Global Fund Concerns Over Alleged Corruption at India's NACO 2Health News:Saturn Celebrates 11 Years of Helping Save Lives Through Blood, Marrow, Organ and Tissue Donation 2Health News:Saturn Celebrates 11 Years of Helping Save Lives Through Blood, Marrow, Organ and Tissue Donation 3Health News:Antidepressants Can Increase Depression, Impulsivity and Suicide Risk by Decreasing Dopamine 2Health News:Antidepressants Can Increase Depression, Impulsivity and Suicide Risk by Decreasing Dopamine 3
(Date:7/31/2014)... 2014 Lazarus Effect, a medical device company ... facilitate removal of blood clots, announced the closing of ... support EU commercialization of several approved Lazarus Effect devices, ... and Lazarus Cover™ in the United States ... in the value of our novel, platform technology as ...
(Date:7/31/2014)... Colo. , July 31, 2014  Cannabis ... in cannabis formulation-based drug development and related consulting, ... production of multiple strains of cannabis and European ... to select the best strains for development of ... the cannabis formulations to market for critical ailments ...
(Date:7/31/2014)... July 31, 2014 For the first time, ... the implantation of the SynCardia temporary Total Artificial Heart ... video posted on the Journal of Visualized Experiments website. ... the paper on the SynCardia Total Artificial Heart implantation ... accompanies "Implantation of the SynCardia Total Artificial Heart," a ...
Breaking Medicine Technology:Lazarus Effect Closes $5 Million Financing 2Cannabis Science Initiates Scientific Cultivation Programs to Test Multiple Strains of Cannabis to Obtain Extract Formulations for Clinical Drug Development Targeting Multiple Critical Ailments Starting with Cancer and Neurological Disorders 2How to Implant the SynCardia Total Artificial Heart Detailed in Peer Reviewed Paper and Matching Video 2How to Implant the SynCardia Total Artificial Heart Detailed in Peer Reviewed Paper and Matching Video 3
Cushing Little Joker periosteal elevators, solid handle, blade width 1/4" (6 mm), length 7 1/2" (191 mm)....
Molt 9 periosteal elevators....
Alexander periosteal elevators....
Lambotte periosteal elevators....
Medicine Products: