Navigation Links
Morria Biopharmaceuticals Plc Announces Preliminary Results Regarding Inflammatory Markers From its Phase II Study in Allergic Rhinitis
Date:10/29/2008

LONDON, Oct. 29 /PRNewswire/ -- Morria Biopharmaceuticals Plc, a biopharmaceutical company focused on the development of novel, anti-inflammatory drugs, announced today the preliminary results from its recently completed Phase II equivalent study of MRX-4, in a nasal aerosol formulation, in 105 patients suffering from allergic rhinitis (AR). The two-arm, randomized, multi-dose, double-blind, placebo-controlled study included Rhinocort(R) as the steroid comparator arm.

A secondary efficacy endpoint of this study was the effect of MRX-4 on inflammatory mediators/markers in the nasal lavage of selected patients following allergen stimulus. The patients were pre-treated by either a placebo or MRX-4 for 7 days twice per day (b.i.d.) beforehand.

MRX-4 demonstrates an overall trend of reducing the levels of five inflammatory mediators: IL-5 (interleukin-5), IL-13, TNF-alpha (Tumor Necrosis Factor alpha), MCP-1 (Monocyte Chemoattractant Protein-1) and Eotoxin. These mediators have been shown to play an important role in various inflammatory diseases such as allergic rhinitis, asthma, skin and intestinal inflammation and arthritis. All have previously been shown to be modulated by MRX-4 in vitro and in vivo in pre-clinical models. This is the first time that such modulation has been observed in patients.

In addition, the levels of eosinophils were tested in the nasal lavage. Eosinophils are white blood cells that play a key role in the allergic response. MRX-4 reduced the levels of these cells compared to placebo-treated patients.

"We are pleased by the wide range of divergent inflammatory mediators that we are modulating, several of which have been extensively covered in the scientific literature recently. Mediators, such as IL-5, IL-13 and TNF-alpha, are currently targets of research and development in the pharmaceutical field for treating respiratory inflammatory diseases, and MRX-4 modulates them in these patients," said Yuval Cohen, Pr
'/>"/>

SOURCE Morria Biopharmaceuticals Plc
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2

Related medicine news :

1. Presentation Time Correction: Keryx Biopharmaceuticals Presents at 12:00pm, ET Tomorrow (Oct. 3) at William Blair & Company Small-Cap Growth Stock Conference
2. Nabi Biopharmaceuticals Announces Third Quarter 2007 Financial Results and Positive Vote from November 8, 2007 Special Stockholders Meeting
3. Nabi Biopharmaceuticals Completes Sale of Nabi Biologics to Biotest AG
4. Keryx Biopharmaceuticals, Inc. Announces Poster Presentations Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) to be Presented at the Upcoming American Society of Hematology Meeting in Atlanta, Georgia
5. XTL Biopharmaceuticals Announces Financial Results for the Year Ended December 31, 2007
6. Keryx Biopharmaceuticals, Inc. Announces Second Quarter 2008 Financial Results
7. HHS Announces $75 Million in Supplemental Funding to States for Pandemic Flu Preparedness
8. CRC Health Group Announces Acquisition of Bayside Marin Recovery Center, San Rafael
9. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
10. HEI, Inc. Announces Sale of RFID Division Assets
11. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Generic Version of Zyloprim(R)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... -- Low-income, minority parents have more realistic views ... open to vaccinating their daughters against the cervical ... contends. Conversely, white, middle-class parents are more ... according to researchers from the Boston University School ... an HPV-related cancer each year, many of which ...
(Date:5/24/2013)... (PRWEB) May 24, 2013 According to a ... Facebook: Social Media Leads to Spikes in Plastic Surgery ... is a growing prevalence of facial plastic surgery ... These people have become keenly aware of the need to ... such as Facebook, Google and even Skype's video chat feature ...
(Date:5/24/2013)... York, New York (PRWEB) May 24, 2013 ... 101 Mobility® is a leading nationwide sales, ... solutions for both consumer and commercial applications. The ... vertical platform lifts, vehicle lifts for mobility devices, ... among others. 101 Mobility operates over 30 locations, ...
(Date:5/24/2013)... 24 (HealthDay News) -- Two out of five medical ... new study found. The study authors, from Wake ... a significant barrier to the treatment of obesity. They ... is necessary to improve care for the millions of ... affect clinical care and the doctor-patient relationship, and even ...
(Date:5/24/2013)... A new investigational device - the Helio System (TF-FA) ... Transcatheter Heart Valve was successfully deployed in all four ... use in high-risk aortic insufficiency reported at EuroPCR 2013. ... to help stabilise the SAPIEN XT valve for patients ... are captured between the transcatheter heart valve and the ...
Breaking Medicine News(10 mins):Health News:Low-Income, Minority Parents More Open to HPV Vaccine for Girls, Study Says 2Health News:Facebook and Google – Is Social Media Driving Demand for Plastic Surgery? 2Health News:Cortec Closes Equity Transaction with 101 Mobility 2Health News:Many Medical Students Have Anti-Fat Bias, Study Finds 2Health News:Feasibility trial reports deployment of new device for TAVI in aortic insufficiency 2
... approved at annual shareholder meeting , , SALT LAKE CITY, ... overwhelmingly approved the renaming of Sonic Innovations, Inc. to Otix Global, ... meeting May 7, 2009. The company has filed the appropriate ... effect on June 15, 2009. , , ...
... HUNTINGTON BEACH, Calif., June 8 Forterus Inc. (Pink Sheets: ... alcohol rehabilitation and a variety of other healthcare services, with ... renewing an offer to provide free outpatient treatment to military ... or Afghanistan war zones within the last five years. , ...
... , ... 4.0 allows help desk staff to administer and remotely control Windows computers. Unlike similar ... to find computers With its unique search engine. It can find the computer you ... , ...
... ARBOR, Mich. Women are under-represented in clinical cancer ... study by researchers at the University of Michigan Comprehensive ... particular types of cancer among women, studies included a ... analysis looked specifically at studies of cancer types that ...
... A ... in facelift surgery and what benefits these techniques have for the patient. , ... Manchester, UK (PRWeb UK) 07 June, 2009 ... clinics / providers of cosmetic surgery than ever before. As a result there is an ...
... can do a lot to keep kids safe, experts say, , ... to be), youngsters are probably going to be spending less ... doing cannonballs. , It,s all fun and games -- until someone ... warn child safety experts. , Though many injuries amount to little ...
Cached Medicine News:Health News:Otix Global, Inc. to Become Parent Company of Sonic Innovations, Inc. 2Health News:Otix Global, Inc. to Become Parent Company of Sonic Innovations, Inc. 3Health News:Forterus Inc. Announces Free Outpatient Treatment to Military Veterans Back from War Zones 2Health News:Windows XP, Vista, and Windows 7 Compatible Remote Control 4.0 Beta Released by IntelliAdmin, LLC 2Health News:Women under-represented in cancer research, U-M study finds 2Health News:Latest Developments In Facelift Surgery - Expert Opinion by Mr James Murphy 2Health News:Latest Developments In Facelift Surgery - Expert Opinion by Mr James Murphy 3Health News:Summer Fun Need Not Be Hazardous 2
(Date:5/24/2013)... 2013  Auxilium Pharmaceuticals, Inc. (Nasdaq: AUXL ... the Deutsche Bank Health Care Conference to be held ... Adrian Adams , Chief Executive Officer ... the Company and its product pipeline at 12:00 p.m. ... (Logo: http://photos.prnewswire.com/prnh/20101202/MM10881LOGO ) The presentation will ...
(Date:5/23/2013)... 24, 2013 3SBio Inc. (NASDAQ: ... leading China -based biotechnology company ... products, announced today that, at an extraordinary general ... voted in favor of the proposal to authorize ... of merger dated February 8, 2013, among Decade ...
(Date:5/23/2013)... BRAINTREE, Mass. , May 23, 2013  Haemonetics Corporation ... Chris Lindop , CFO & EVP-Business Development, will present ... Care Conference in Boston, MA on ... (Logo: http://photos.prnewswire.com/prnh/20120206/NE47232LOGO ) The public may ... About Haemonetics Haemonetics (NYSE: ...
Breaking Medicine Technology:Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 2Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 3Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 43SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 23SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 3
... is the most versatile orthopedic/trauma ... designed for both lower body ... an integrated shoulder attachment. The ... operating table for your most ...
... is restricted. Due to its excellent drive ... every situation. For many complicated surgery positions, ... on the JUPITER during the induction to ... the high level of stability of JUPITER ...
... universal operating table for any application. ... for unlimited C-arm access. High stability ... neurosurgical and cardiovascular procedures. An extension ... support can easily be attached for ...
... The Medstone Pro-2000BT carbon fiber ... unobstructed imaging for urology, brachytherapy, gynecology, ... other procedures. The open design allows ... movements include up to 16-inch elevating ...
Medicine Products: