Navigation Links
Morphine May Protect Brains of People With HIV

Painkiller produces protein that inhibits disease-related dementia, study finds,,

FRIDAY, April 16 (HealthDay News) -- The painkiller morphine may help protect against HIV-associated dementia, says a new study.

Georgetown University Medical Center researchers found that morphine protected rat neurons from HIV toxicity, a discovery that could lead to the development of new drugs to treat people with HIV-related dementia, which causes depression, anxiety and physical and mental problems.

"We believe that morphine may be neuroprotective in a subset of people infected with HIV," lead investigator Italo Mocchetti, a professor of neuroscience, said in a Georgetown news release.

He and his colleagues conducted the study because they knew that some people with HIV who are heroin users never develop HIV brain dementia. Morphine is similar to heroin.

In their tests on rats, the researchers found that morphine triggers brain cells called astrocytes to produce a protein called CCL5, which activates factors that suppress HIV infection in immune cells.

CCL5 "is known to be important in blood, but we didn't know it is secreted in the brain," Mocchetti said. "Our hypothesis is that it is in the brain to prevent neurons from dying."

The study was to be presented at the annual meeting of the Society of NeuroImmune Pharmacology, April 13 to 17 in Manhattan Beach, Calif.

"Ideally, we can use this information to develop a morphine-like compound that does not have the typical dependency and tolerance issues that morphine has," Mocchetti said.

More information

The Family Caregiver Alliance has more about HIV-associated dementia.

-- Robert Preidt

SOURCE: Georgetown University Medical Center, news release, April 15, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Roxane Laboratories, Inc. Announces the New Drug Application Approval of Morphine Sulfate Oral Solution CII, 100mg/5mL (20mg/mL)
2. B-vitamins Help Protect Against Stroke, Heart Disease
3. Flu Vaccine With Both B Strains May Offer Better Protection
4. CLIF BAR Family Foundation Commits $500,000 to Protect and Promote Organic Seed and Farming
5. Sun protection program increases hat use among 4th graders
6. EarPeace Protects Hearing for Thousands at South by Southwest
7. Sun protection program increases hat use among 4th-graders
8. Pregnancy May Protect Breast Cancer Survivors
9. Study finds surgical masks provided effective protection of health-care workers against H1N1
10. Bishops Encourage Vigilance that Health Care Legislation Protects Conscience, Does Not Fund Abortion
11. Diversinets New MobiSecure(R) SMS Provides Healthcare Organizations With Secure and Protected SMS Communications
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... Altec Products, ... Title Sponsorship of Synergy 2015. The annual WennSoft KEY2ACT user conference will take ... and will unite customers, partners, WennSoft team members and sponsors to facilitate the ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... County, Illinois with more than 59,000 emergency department visits per year, today announced ... from T-System, to help improve clinical, operational and financial outcomes. , ...
(Date:10/13/2015)... ... 2015 , ... California Southern University has named Dr. Judith ... Doctor of Nursing Practice from the renowned Johns Hopkins University—comes to CalSouthern with ... McLeod’s long and successful nursing practice included a variety of patient care, education ...
(Date:10/13/2015)... CA (PRWEB) , ... October 13, 2015 , ... According ... Derrick Rose suffered an orbital fracture when a teammate accidentally elbowed him in the ... 2015. Rose's recent eye injury is just one of a series of setbacks, including ...
(Date:10/13/2015)... ... ... With Fall weather approaching and holiday travel season upon us, is giving away ... to win! , How to Enter:, 1. Like on Facebook , 2. ... us on Instagram @thebeautyplace , 4. Share Facebook Contest Image With Friends , ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... Research and Markets ( ) has announced the ... Yeast, Mold, Others), Flavors (Herbs & Spices, Citrus, Berries, ... - Forecasts to 2020" report to their offering. ... --> The global market for kombucha has grown ... value, the market is projected to reach USD 1.8 ...
(Date:10/13/2015)... WuXi PharmaTech (Cayman) Inc. (NYSE:  WX), a ... serving the pharmaceutical, biotechnology, and medical device industries, ... version of OncoWuXi, the first App in the ... and data on the go.  The OncoWuXi App ... to identify relevant tumor models for use in ...
(Date:10/13/2015)... , Oct. 13, 2015  The ... Harvard University today announced the launch of ... Ultivue will introduce imaging reagents providing ... to those of expensive specialized instruments. The ... Harvard,s Office of Technology Development (OTD) ...
Breaking Medicine Technology: