Navigation Links
Morphine May Protect Brains of People With HIV
Date:4/16/2010

Painkiller produces protein that inhibits disease-related dementia, study finds,,

FRIDAY, April 16 (HealthDay News) -- The painkiller morphine may help protect against HIV-associated dementia, says a new study.

Georgetown University Medical Center researchers found that morphine protected rat neurons from HIV toxicity, a discovery that could lead to the development of new drugs to treat people with HIV-related dementia, which causes depression, anxiety and physical and mental problems.

"We believe that morphine may be neuroprotective in a subset of people infected with HIV," lead investigator Italo Mocchetti, a professor of neuroscience, said in a Georgetown news release.

He and his colleagues conducted the study because they knew that some people with HIV who are heroin users never develop HIV brain dementia. Morphine is similar to heroin.

In their tests on rats, the researchers found that morphine triggers brain cells called astrocytes to produce a protein called CCL5, which activates factors that suppress HIV infection in immune cells.

CCL5 "is known to be important in blood, but we didn't know it is secreted in the brain," Mocchetti said. "Our hypothesis is that it is in the brain to prevent neurons from dying."

The study was to be presented at the annual meeting of the Society of NeuroImmune Pharmacology, April 13 to 17 in Manhattan Beach, Calif.

"Ideally, we can use this information to develop a morphine-like compound that does not have the typical dependency and tolerance issues that morphine has," Mocchetti said.

More information

The Family Caregiver Alliance has more about HIV-associated dementia.



-- Robert Preidt



SOURCE: Georgetown University Medical Center, news release, April 15, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Roxane Laboratories, Inc. Announces the New Drug Application Approval of Morphine Sulfate Oral Solution CII, 100mg/5mL (20mg/mL)
2. B-vitamins Help Protect Against Stroke, Heart Disease
3. Flu Vaccine With Both B Strains May Offer Better Protection
4. CLIF BAR Family Foundation Commits $500,000 to Protect and Promote Organic Seed and Farming
5. Sun protection program increases hat use among 4th graders
6. EarPeace Protects Hearing for Thousands at South by Southwest
7. Sun protection program increases hat use among 4th-graders
8. Pregnancy May Protect Breast Cancer Survivors
9. Study finds surgical masks provided effective protection of health-care workers against H1N1
10. Bishops Encourage Vigilance that Health Care Legislation Protects Conscience, Does Not Fund Abortion
11. Diversinets New MobiSecure(R) SMS Provides Healthcare Organizations With Secure and Protected SMS Communications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet ... product that was developed to enhance the health of felines. The formula is all-natural ... two main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CLEMENTE, Calif. , June 24, 2016  American Respiratory Labs ... company, is now able to perform sophisticated lung assessments in patients, ... Technologies , Inc. Patients are no longer limited ... ndd,s EasyOne PRO ® , ARL patients like Jeanne R. of ... done in the comfort of her own home. ...
(Date:6/24/2016)... NAMUR , Belgium , ...  (NYSE MKT: VNRX), today announced the appointment of ... Board of Directors as a Non-Executive Director, effective ... the Company,s Audit, Compensation and Nominations and Governance ... Board, Dr. Futcher will provide independent expertise and ...
(Date:6/23/2016)... Any dentist who has made an implant supported ... Many of them do not even offer this as a ... laboratory costs involved. And those who ARE able to offer ... high cost that the majority of today,s patients would not ... Zadeh , founder of Dental Evolutions Inc. and inventor of ...
Breaking Medicine Technology: