Navigation Links
Morphine May Protect Brains of People With HIV
Date:4/16/2010

Painkiller produces protein that inhibits disease-related dementia, study finds,,

FRIDAY, April 16 (HealthDay News) -- The painkiller morphine may help protect against HIV-associated dementia, says a new study.

Georgetown University Medical Center researchers found that morphine protected rat neurons from HIV toxicity, a discovery that could lead to the development of new drugs to treat people with HIV-related dementia, which causes depression, anxiety and physical and mental problems.

"We believe that morphine may be neuroprotective in a subset of people infected with HIV," lead investigator Italo Mocchetti, a professor of neuroscience, said in a Georgetown news release.

He and his colleagues conducted the study because they knew that some people with HIV who are heroin users never develop HIV brain dementia. Morphine is similar to heroin.

In their tests on rats, the researchers found that morphine triggers brain cells called astrocytes to produce a protein called CCL5, which activates factors that suppress HIV infection in immune cells.

CCL5 "is known to be important in blood, but we didn't know it is secreted in the brain," Mocchetti said. "Our hypothesis is that it is in the brain to prevent neurons from dying."

The study was to be presented at the annual meeting of the Society of NeuroImmune Pharmacology, April 13 to 17 in Manhattan Beach, Calif.

"Ideally, we can use this information to develop a morphine-like compound that does not have the typical dependency and tolerance issues that morphine has," Mocchetti said.

More information

The Family Caregiver Alliance has more about HIV-associated dementia.



-- Robert Preidt



SOURCE: Georgetown University Medical Center, news release, April 15, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Roxane Laboratories, Inc. Announces the New Drug Application Approval of Morphine Sulfate Oral Solution CII, 100mg/5mL (20mg/mL)
2. B-vitamins Help Protect Against Stroke, Heart Disease
3. Flu Vaccine With Both B Strains May Offer Better Protection
4. CLIF BAR Family Foundation Commits $500,000 to Protect and Promote Organic Seed and Farming
5. Sun protection program increases hat use among 4th graders
6. EarPeace Protects Hearing for Thousands at South by Southwest
7. Sun protection program increases hat use among 4th-graders
8. Pregnancy May Protect Breast Cancer Survivors
9. Study finds surgical masks provided effective protection of health-care workers against H1N1
10. Bishops Encourage Vigilance that Health Care Legislation Protects Conscience, Does Not Fund Abortion
11. Diversinets New MobiSecure(R) SMS Provides Healthcare Organizations With Secure and Protected SMS Communications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association ... Featuring a collection of specialty vendors and unique items from across the nation, this ... health and wellness services offered by the VNA. The boutique will be open ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and ... explains one of the most popular and least understood books in the Holy Scriptures, ... puzzling descriptions that have baffled scholars for centuries. Many have tossed it off as ...
(Date:10/13/2017)... ... ... Journey: From the Mountains to the Mission Field”: the story of a missionary couple ... From the Mountains to the Mission Field” is the creation of published author, Carole ... and currently teaches a class of ladies at her church, which she has taught ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... are now treating sleep apnea using cutting-edge Oventus O2Vent technology. As ... serious sleep disorder characterized by frequent cessation in breathing. Oral appliances can offer ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), ... of an innovative new design of the shoulder pad. The shoulder pad provides ... while controlling your pain while using cold therapy. By utilizing ice and water that ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") ... Surgical facility in Las Piedras, Puerto Rico ... and blades. ... the facility sustained minor structural damage, temporary loss of ... Repairs have been completed, manufacturing operations have resumed, and ...
(Date:10/5/2017)... Oct. 5, 2017  In response to the ... and Maxillofacial Surgeons (AAOMS) released prescribing recommendations that ... be used as a first-line therapy to manage ... Recognizing the value and ... Paper "Opioid Prescribing: Acute and Postoperative Pain Management" ...
(Date:10/2/2017)... Diplomat Pharmacy, Inc. (NYSE: DPLO ... LLC , and named its founder as Diplomat,s chief ... Tennessee , will operate under Diplomat subsidiary ... offerings for health care partners to include IT outsourcing, ... "In an interoperable world, technology delivers comprehensive insight ...
Breaking Medicine Technology: