Navigation Links
Morphine May Help Tumors Spread in Cancer Patients
Date:11/18/2009

Lab study finds that common surgical painkillers help cancer cells thrive

WEDNESDAY, Nov. 18 (HealthDay News) -- Two new studies add to growing evidence that morphine and other opiate-based painkillers may promote the growth and spread of cancer cells.

The papers, scheduled to be presented Wednesday at an international cancer conference in Boston, also demonstrate how preventing opiates from reaching lung cancer cells reduces cancer cell proliferation, invasion and migration.

The findings from tests with cell cultures and mice suggest that the mu opiate receptor -- where morphine acts in the body -- may offer a potential treatment target.

"If confirmed clinically, this could change how we do surgical anesthesia for our cancer patients. It also suggests potential new applications for this novel class of drugs which should be explored," Patrick A. Singleton, an assistant professor of medicine at the University of Chicago and principal author of both studies, said in a university news release.

Morphine can increase tumor cell proliferation, inhibit the immune system, promote the growth of new blood vessels (angiogenesis) that feed tumors and decrease barrier function. In cancer patients undergoing surgery, decreased barrier function may make it easier for tumors to invade tissue and spread to other parts of the body, while increased angiogenesis helps tumors thrive in a new location.

Singleton and colleagues found that mice without the mu opiate receptor didn't develop tumors when injected with lung cancer cells, while normal mice did develop cancer. The researchers also found that methylnaltrexone -- developed to treat opiate-induced constipation -- reduced the proliferation of cancer cells in normal mice by 90 percent.

More information

The U.S. National Cancer Institute has more about metastatic cancer.



-- Robert Preidt



SOURCE: University of Chicago Medical Center, news release, Nov. 18, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. FDA Reverses Stance on Removal of Morphine Painkiller
2. GSU study first to confirm long-term benefits of morphine treatment in infants
3. Roxane Laboratories, Inc. Announces the Approval of Morphine Sulfate Tablets and Oral Solution
4. ETHEX Corporation Voluntarily Recalls a Single Lot of Morphine Sulfate 60 mg Extended Release Tablets Due to the Potential for Oversized Tablets
5. Morphine dependency blocked by single genetic change
6. Morphine: a comfort measure for the dying or pain control for the living?
7. Blocking Potent Oxidant Could Prevent Morphine Tolerance
8. KV Pharmaceutical Announces FDA Approval for Morphine ER 100 mg and 200 mg Tablets
9. Morphine Painkillers Wont Impair Driving
10. Wistar researchers show targeting normal cells in tumors slows growth
11. Drug shrinks lung cancer tumors in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... (PRWEB) , ... May 05, 2016 , ... ... conditions and Make-A-Wish grants the most heartfelt wishes of these children. The ... of medical treatment. President and CEO of Make-A-Wish Mississippi, Brent Wilson said, ...
(Date:5/5/2016)... ... ... Long Island’s fastest growing comprehensive eye care provider, North Shore Eye ... Valkenburg, MD as part of their ongoing effort to increase ophthalmic coverage in their ... of North Shore Eye Care. , “We are extremely proud to welcome ...
(Date:5/5/2016)... ... ... TIME for Kids and The ZAC Foundation – a national leader in drowning ... million children with important water safety messages before summer break begins. , ... in children one to 6 years of age. TIME for Kids and The ...
(Date:5/5/2016)... ... , ... In honor of National Nurses Week 2016, Aya Healthcare , ... to thank a nurse who's made a difference in their life. From Friday, May ... Cross of San Diego/Imperial Counties (up to $10,000) every time someone tells them via ...
(Date:5/5/2016)... ... ... Lung Institute will celebrate its three-year anniversary on May 14 by giving away a ... of May. To date, the Lung Institute has treated over 2,000 people at their five ... to the success of this treatment and to the patients who refuse to give up,” ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... 2016 Research and ... Thalassaemia Market and Competitive Landscape Highlights - ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) ... Competitive Landscape Highlights - 2016, provides comprehensive ... Thalassaemia market valuations and forecast, Thalassaemia products ...
(Date:5/4/2016)... May 4, 2016 According to ... entitled "Brain Computer Interface Market - Global Industry Analysis, Size, ... brain computer interface (BCI) market  is expected to reach ... is estimated to expand at a CAGR of 14.9 ... A BCI device provides collaboration between the ...
(Date:5/4/2016)... -- According to market research "Global Computed Tomography ... 2022 - Industry Insights by Slice Type (High, Mid and ... P&S Market Research, the global computed tomography market ... expected to grow at a CAGR of 5.0% during 2016-2022. ... expected to witness the faster growth, CAGR of 5.3%, during ...
Breaking Medicine Technology: