Navigation Links
Morphine May Help Tumors Spread in Cancer Patients
Date:11/18/2009

Lab study finds that common surgical painkillers help cancer cells thrive

WEDNESDAY, Nov. 18 (HealthDay News) -- Two new studies add to growing evidence that morphine and other opiate-based painkillers may promote the growth and spread of cancer cells.

The papers, scheduled to be presented Wednesday at an international cancer conference in Boston, also demonstrate how preventing opiates from reaching lung cancer cells reduces cancer cell proliferation, invasion and migration.

The findings from tests with cell cultures and mice suggest that the mu opiate receptor -- where morphine acts in the body -- may offer a potential treatment target.

"If confirmed clinically, this could change how we do surgical anesthesia for our cancer patients. It also suggests potential new applications for this novel class of drugs which should be explored," Patrick A. Singleton, an assistant professor of medicine at the University of Chicago and principal author of both studies, said in a university news release.

Morphine can increase tumor cell proliferation, inhibit the immune system, promote the growth of new blood vessels (angiogenesis) that feed tumors and decrease barrier function. In cancer patients undergoing surgery, decreased barrier function may make it easier for tumors to invade tissue and spread to other parts of the body, while increased angiogenesis helps tumors thrive in a new location.

Singleton and colleagues found that mice without the mu opiate receptor didn't develop tumors when injected with lung cancer cells, while normal mice did develop cancer. The researchers also found that methylnaltrexone -- developed to treat opiate-induced constipation -- reduced the proliferation of cancer cells in normal mice by 90 percent.

More information

The U.S. National Cancer Institute has more about metastatic cancer.



-- Robert Preidt



SOURCE: University of Chicago Medical Center, news release, Nov. 18, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. FDA Reverses Stance on Removal of Morphine Painkiller
2. GSU study first to confirm long-term benefits of morphine treatment in infants
3. Roxane Laboratories, Inc. Announces the Approval of Morphine Sulfate Tablets and Oral Solution
4. ETHEX Corporation Voluntarily Recalls a Single Lot of Morphine Sulfate 60 mg Extended Release Tablets Due to the Potential for Oversized Tablets
5. Morphine dependency blocked by single genetic change
6. Morphine: a comfort measure for the dying or pain control for the living?
7. Blocking Potent Oxidant Could Prevent Morphine Tolerance
8. KV Pharmaceutical Announces FDA Approval for Morphine ER 100 mg and 200 mg Tablets
9. Morphine Painkillers Wont Impair Driving
10. Wistar researchers show targeting normal cells in tumors slows growth
11. Drug shrinks lung cancer tumors in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... March 23, 2017 , ... Michael Lanteri Agency, an insurance ... Collins area, has unveiled a collaboration with nonprofit Big Bones Canine Rescue as ... worthy cause may now be made at http://bigbonescaninerescue.com/ . , Big Bones ...
(Date:3/23/2017)... ... March 23, 2017 , ... After raising more than $1.135 million ($1,479,231 ... travel pillow in crowdfunding history, has established a U.S. Headquarters in New ... innovation to Americans. , “We’re excited to be operating on U.S. shores, where most ...
(Date:3/23/2017)... ... ... feature 150+ Hospital and Health System Executive Speakers including: , , ... of the United States of America: George W. Bush , Boxing Legend, Successful ... Ray Leonard , JD, Chairperson, McGuireWoods LLP: Amber McGraw Walsh , ...
(Date:3/23/2017)... ... , ... Sharon Kleyne, host of the nationally syndicated radio program, The Sharon ... talked on her program about how she is looking forward to World Water Day ... important distinction. World Water Day, Kleyne pointed out, is an occasion for looking ahead ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... supplements that help improve all aspects of people’s health and nutrition, announced its ... nutritional products. , Natural Subsistence develops nutritional supplements that help people improve ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... 2017  Ethicon* today announced the completion of ... held medical device company that manufactures and markets ... treatment of Gastroesophageal Reflux Disease (GERD). This acquisition ... portfolio of minimally invasive options for patients suffering ... of the transaction have not been disclosed. ...
(Date:3/23/2017)... YORK , March 23, 2017 ... sample preparation market is expected to reach USD 7.2 billion ... of 7.1%. Sample preparation is a procedure in which a ... crucial step in most analytical procedures since the methods are ... preparation is one of the most shared procedures in the ...
(Date:3/23/2017)... 2017  Drug diversion is a significant contributing ... overdoses. A new oral fluid monitoring test, announced ... reports more detailed and actionable information to clinicians ... therapy adherence, patient safety, and help to identify ... fluid Rx Evaluation (CORE) system is the first ...
Breaking Medicine Technology: