Navigation Links
Morphine May Help Tumors Spread in Cancer Patients
Date:11/18/2009

Lab study finds that common surgical painkillers help cancer cells thrive

WEDNESDAY, Nov. 18 (HealthDay News) -- Two new studies add to growing evidence that morphine and other opiate-based painkillers may promote the growth and spread of cancer cells.

The papers, scheduled to be presented Wednesday at an international cancer conference in Boston, also demonstrate how preventing opiates from reaching lung cancer cells reduces cancer cell proliferation, invasion and migration.

The findings from tests with cell cultures and mice suggest that the mu opiate receptor -- where morphine acts in the body -- may offer a potential treatment target.

"If confirmed clinically, this could change how we do surgical anesthesia for our cancer patients. It also suggests potential new applications for this novel class of drugs which should be explored," Patrick A. Singleton, an assistant professor of medicine at the University of Chicago and principal author of both studies, said in a university news release.

Morphine can increase tumor cell proliferation, inhibit the immune system, promote the growth of new blood vessels (angiogenesis) that feed tumors and decrease barrier function. In cancer patients undergoing surgery, decreased barrier function may make it easier for tumors to invade tissue and spread to other parts of the body, while increased angiogenesis helps tumors thrive in a new location.

Singleton and colleagues found that mice without the mu opiate receptor didn't develop tumors when injected with lung cancer cells, while normal mice did develop cancer. The researchers also found that methylnaltrexone -- developed to treat opiate-induced constipation -- reduced the proliferation of cancer cells in normal mice by 90 percent.

More information

The U.S. National Cancer Institute has more about metastatic cancer.



-- Robert Preidt



SOURCE: University of Chicago Medical Center, news release, Nov. 18, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. FDA Reverses Stance on Removal of Morphine Painkiller
2. GSU study first to confirm long-term benefits of morphine treatment in infants
3. Roxane Laboratories, Inc. Announces the Approval of Morphine Sulfate Tablets and Oral Solution
4. ETHEX Corporation Voluntarily Recalls a Single Lot of Morphine Sulfate 60 mg Extended Release Tablets Due to the Potential for Oversized Tablets
5. Morphine dependency blocked by single genetic change
6. Morphine: a comfort measure for the dying or pain control for the living?
7. Blocking Potent Oxidant Could Prevent Morphine Tolerance
8. KV Pharmaceutical Announces FDA Approval for Morphine ER 100 mg and 200 mg Tablets
9. Morphine Painkillers Wont Impair Driving
10. Wistar researchers show targeting normal cells in tumors slows growth
11. Drug shrinks lung cancer tumors in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set ... drug or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, ... traumatic event. , Trauma sufferers tend to feel a range of emotions, from depression, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and ... women in the world, and the most handsome men, look naturally attractive. Plastic ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 According to a new ... Pen Needles, Safety Pen Needles), Needle Length (4mm, 5mm, ... Mode of Purchase (Retail, Non-Retail) - Trends & Global ... the market for the forecast period of 2016 to ... Billion by 2021 from USD 1.65 Billion in 2016, ...
(Date:6/23/2016)... 23, 2016  MedSource announced today that it ... software solution of choice.  This latest decision demonstrates ... to their clients by offering a state-of-the-art electronic ... establishes nowEDC as the EDC platform of choice ... clients.  "nowEDC has long been a preferred EDC ...
(Date:6/23/2016)... Ill. , June 23, 2016  In a startling report ... are failing their residents by lacking a comprehensive, proven plan to ... a definitive ranking of how states are tackling the worst ... to only four states – Kentucky , ... Vermont . Of the 28 failing states, three ...
Breaking Medicine Technology: