Navigation Links
More than two-thirds of healthy Americans are infected with human papilloma viruses
Date:5/20/2014

In what is believed to be the largest and most detailed genetic analysis of its kind, researchers at NYU Langone Medical Center and elsewhere have concluded that 69 percent of healthy American adults are infected with one or more of 109 strains of human papillomavirus (HPV). Only four of the 103 men and women whose tissue DNA was publicly available through a government database had either of the two HPV types known to cause most cases of cervical cancer, some throat cancers, and genital warts.

Researchers say that while most of the viral strains so far appear to be harmless and can remain dormant for years, their overwhelming presence suggests a delicate balancing act for HPV infection in the body, in which many viral strains keep each other in check, preventing other strains from spreading out of control. Although infection is increasingly known to happen through skin-to-skin contact, HPV remains the most common sexually transmitted infection in the United States. It is so common that experts estimate nearly all men and women contract some strain of it during their lives.

"Our study offers initial and broad evidence of a seemingly 'normal' HPV viral biome in people that does not necessarily cause disease and that could very well mimic the highly varied bacterial environment in the body, or microbiome, which is key to maintaining good health," says senior study investigator and NYU Langone pathologist Zhiheng Pei, MD, PhD. Dr. Pei, an associate professor at NYU Langone, plans to present his team's findings on May 20 in Boston at the annual meeting of the American Society for Microbiology.

Lead study investigator and NYU Langone research scientist Yingfei Ma, PhD, says "the HPV 'community' in healthy people is surprisingly more vast and complex than previously thought, and much further monitoring and research is needed to determine how the various non-cancer-causing HPV genotypes interact with the cancer-causing strains, such as genotypes 16 and 18, and what causes these strains to trigger cancer."

For the study, which took two years to complete, researchers analyzed data made publicly available from the National Institutes of Health (NIH) Human Microbiome Project, which is gathering information on microorganisms' effects on human health.

The NIH data consisted of comprehensive DNA analyses assembled by a technique called shotgun sequencing. The DNA decoding technique helped sort through vast amounts of genetic material among 748 tissue swabs of study participants' major organs, including skin, vagina, mouth, and gut. Tissue samples were originally collected from healthy study volunteers, ages 18 to 80, participating in the NIH project. In shotgun sequencing, the genetic code of long strands of DNA is deciphered in a random firing pattern, much like pixels in a photo, until a full picture becomes apparent.

Researchers then refined their analysis to only HPV strains by removing all human DNA sequences and, using special bioinformatics software developed at NYU Langone, comparing what was left with known national databases on HPV.

Dr. Pei cautions that until the harm or benefits of the many HPV strains become apparent, people should not be overly concerned, but consult their physician or an infectious disease specialist to assess any potential threat before seeking any antiviral or other therapy. In addition, he says getting vaccinated against types 16 and 18 is still "a good idea," especially for preventing cervical cancer, until broader, more comprehensive anti-HPV vaccines become available that also target cancers in other body organs and tissues.

Among the study's other key findings:

  • Some 109 of 148 known HPV types were detected in study participants.

  • Most study participants had HPV infections in the skin (61 percent); then vagina (41 percent), mouth (30 percent), and gut (17 percent).

  • Of the 71 study participants infected with HPV, 42 (59 percent) had HPV in only one organ, 22 (31 percent) had it in two organs, and seven (10 percent) had it in three; none had HPV in all four organs tested.

  • Skin samples contained the most varied HPV strains (80 types of HPV, including 40 that were found only in the skin). Vaginal tissue had the second most numerous strains (43 types of HPV, with 20 strains exclusive to the organ), followed by mouth tissue (33 types, of which five were exclusively oral in origin), and gut tissue (six types, all of which were found in other organs).

Dr. Pei says his team's study results also highlight the weaknesses in current clinical test kits for HPV, currently designed to recognize only a dozen or more viral types most closely tied to cervical cancer. He says broader detection methods and comprehensive diagnostic tests are needed to more accurately assess people's "true" HPV infection status.

According to Dr. Ma, the team has plans to investigate which non-cancer-causing HPV types may play a role in cancers of the cervix, mouth and skin. The team also plans to develop better diagnostic tests, which would test for all known types of HPV.


'/>"/>

Contact: David March
david.march@nyumc.org
212-404-3528
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert  

Related medicine news :

1. More than two-thirds of Americans support mandated coverage of birth control in health plans
2. Medical research needs kids, but two-thirds of parents unaware of opportunities
3. Almost two-thirds of women who attempt natural delivery after a c-section are successful
4. Two-Thirds of U.S. Youth Have Had Oral Sex, CDC Reports
5. Two-Thirds of Osteo Hip Fractures Occur After 80: U.S. Study
6. College kids need to change unhealthy ways
7. Critical protein discovered for healthy cell growth in mammals
8. Most women undergoing surgery for vulvar cancer maintain healthy body image and sex life
9. Helping Kids Make Healthy Choices Every Day with the Brilliantly Simple 5-4-3-2-1+10® Program
10. The Metabolic Cooking Review by Go and Get Healthy
11. Sacramento Acupuncture Experts Tian Chao Herbs and Acupuncture Help Customers Stay Healthy With Herbal Medicine, Traditional Chinese Medicine, and Acupuncture
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
More than two-thirds of healthy Americans are infected with human papilloma viruses
(Date:9/20/2017)... ... September 20, 2017 , ... Health & Safety Institute (HSI) is offering discounted ... and 40-Hour courses from now until November 30, 2017 to assist with the clean-up ... prices to all businesses and government agencies – whether or not they will be ...
(Date:9/20/2017)... ... September 20, 2017 , ... “Finn Mouseson”: follows the exciting story ... average life. This mouse sets out on a journey that will show that friends ... the creation of newly published author and illustrator, Melody Gersonde-Mickelson, who has earned a ...
(Date:9/20/2017)... ... September 20, 2017 , ... “The Foggy Road to Moorwick”: the adventures of a young ... creation of published author, Jeanine Liston, a busy mother of five who used her time ... been writing this book for over twenty years. It was a way to give ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... Brazilian jiu-jitsu community have raised more than $15,000 in just a couple of ... professional submission grappling matches and world-class instructor seminars, organizers expect to double those ...
(Date:9/19/2017)... ... ... Trusted debt-reduction firm CreditAssociates, LLC has announced two important milestones. To date, ... million in resolved debt for its clients. , Credit card debt, unpaid hospital bills, ... debt settled by the company. With more than a decade of combined service to ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... N.Y. , Sept. 6, 2017   PDI , ... announced it will host an educational session focused on ... bloodstream infection (CLABSI) prevention at the 2017 Annual Scientific ... which will take place at the Phoenix ... from Sept. 16-19, will also feature PDI,s ...
(Date:9/5/2017)... N.J. , Sept. 5, 2017  Getinge, ... has created a vibrant charitable donation program -- ... and support congenital heart defect research by The ... providers and the general public are encouraged to ... and submit the completed artwork to the gallery ...
(Date:9/1/2017)... 1, 2017  Bayer will present the latest research from ... Medical Oncology (ESMO) 2017 Congress, September 8-12 in ... preclinical and clinical data on Bayer,s marketed portfolio and late-stage ... "We value the ... cancer research at ESMO," said Carsten Brunn , Head ...
Breaking Medicine Technology: