Navigation Links
More surgery in early-stage laryngeal cancer treatment; more chemoradiation for advanced-stage
Date:10/17/2011

CHICAGO The use of surgery to treat early-stage laryngeal cancer (cancer of the voice box) is increasing in the United States, and chemotherapy in combination with radiation therapy is being used increasingly to treat patients in an advanced stage of the disease, according to a report in the October issue of Archives of Otolaryngology Head & Neck Surgery, one of the JAMA/Archives journals.

Cancer of the larynx, or voice box, was diagnosed in nearly 13,000 people in the U.S. in 2010, and 3,660 were projected to die from the disease, according to background information in the article. Early-stage laryngeal cancer has traditionally been treated with radiation therapy or surgical resection (removal of part of the larynx) with comparable successful outcomes.

Amy Y. Chen, M.D., M.P.H., and colleagues at Emory University and the American Cancer Society, Atlanta, conducted a study to examine trends and four-year survival rates of surgical and non-surgical treatment for laryngeal cancer. They analyzed data on 131,694 laryngeal cancer cases diagnosed from 1985 to 2007, identified from the National Cancer Database. The primary treatment information included radiation therapy (RT), chemoradiation (CRT, chemotherapy in combination with radiation therapy), and curative intent surgery.

The authors found that surgical resection of early-stage laryngeal cancer increased over the years, with a corresponding decrease in radiation.

"Among patients with early-stage cancer, the proportion receiving primary surgery increased (from 20 percent in 1985 to 33 percent in 2007), whereas the use of RT decreased from 64 percent to 52 percent," they report. "The four-year survival rate for patients with early-stage laryngeal cancer treated with surgery was higher than the rate for those treated with RT (79 percent vs. 71 percent)."

"Among patients with advanced-stage cancer, the use of CRT increased from less than 7 percent to 45 percent, whereas the use of total laryngectomy [surgical removal of the voice box] decreased from 42 percent to 32 percent," they continue.

Advanced-stage patients who had total laryngectomy had a four-year survival rate of 51 percent. The survival rate for patients treated with CRT was 48 percent, and for those treated with RT the survival rate was 38 percent.

Patients who lived in areas with higher socioeconomic status zip codes and who had private insurance were more likely to be treated with surgery for early-stage laryngeal cancer, and to receive CRT for advanced-stage cancer. Early-stage patients who were not African American, and who were treated at academic facilities, were more likely to receive surgery. Younger patients with advanced-stage cancer were more likely to be treated with CRT.

"Not only were clinical factors associated with type of treatment, but select sociodemographic elements were also associated with treatment," the authors conclude. "Further investigation as to the decision-making process of patients with different sociodemographic backgrounds will assist in mitigating the differences in survival for this group of patients."


'/>"/>
Contact: Kathi Baker
kobaker@emory.edu
404-727-9371
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Repeated Weight-Loss Surgery Carries Added Risks
2. The New Liposuction Technique Means No Surgery or Suction
3. Research validates surgery alone offers reasonable overall survival for stage I SCLC
4. "New Cosmetic Surgery" Journalism Prize
5. Abington Memorial Hospital Welcomes Vakil to Orthopaedic Surgery Division
6. Drug for advanced kidney cancer shrinks tumors prior to surgery
7. Abington Memorial Hospital Earns Two Designations: Blue Distinction Center for Spine Surgery(SM) and Blue Distinction Center for Knee and Hip Replacement(SM)
8. New endoscopic treatment may spare Barretts esophagus patients from surgery
9. Pittsburgh Neurosurgeons Explore Use of Drug that Illuminates Brain Tumor Cells To Guide Surgery
10. Surgery Alone May Thwart Stage 1 Lung Cancer
11. Comparison shows robot-assisted option offers advantages for kidney surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/19/2017)... ... ... Braun Industries will be participating as an exhibitor at EMS Today 2017. ... 23-25, 2017 at the Calvin L. Rampton Salt Palace Convention Center in Salt Lake ... on display. , “JEMS is a leader in EMS news and education. ...
(Date:2/19/2017)... ... February 19, 2017 , ... "At your fingertips" electronic ... MEDfx and the Delaware Health Information Network (DHIN) have partnered to improve connectivity ... state-wide health information exchange, DHIN stores and shares real-time health data for more ...
(Date:2/18/2017)... (PRWEB) , ... February 17, ... ... Change for Devicemakers , Sponsored by Axendia, **FDAnews Free Webinar**, March 1, ... Are manufacturers looking to reduce their regulatory burden? Pay dividends in enhanced ...
(Date:2/18/2017)... ... ... Butler Mobility invited Ken Matthews to visit its manufacturing facility and showroom ... impressed with the safety and reliability of the Stannah Stairlift as well as with ... endorsement by Ken Matthews can be heard on News Radio WHP 580 weekdays from ...
(Date:2/18/2017)... ... 2017 , ... Park Cities Pet Sitter President, Joette White, has been featured ... network. The episode, which was posted this week, features a 30-minute interview of ... Park Cities Pet Sitter’s being awarded the 2017 National Association of Professional Pet Sitter’s ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... Pa. , Feb. 16, 2017 Absorption ... biologics, and medical devices, is pleased to announce that ... has been selected as a winner of the 2017 ... SmartCEO Magazine and recognizes driven executives for their ... work ethic. The awards ceremony and celebration is on ...
(Date:2/16/2017)... 2017  Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ... announced that executive management will participate in the RBC ... 22-23, 2017. Adrian Adams , Chief Executive Officer, ... p.m. local time on Wednesday, February 22, 2017. ... event may be accessed from the Investors section of ...
(Date:2/16/2017)... YORK , Feb. 16, 2017 Summary ... agreements entered into by the worlds leading healthcare companies. ... Description The Global Allergy ... to partnering deals and agreements entered into by the world,s leading ... - Top deals by value - Deals listed by company ...
Breaking Medicine Technology: