Navigation Links
More sun exposure may be good for some people
Date:1/7/2008

UPTON, NY - A new study by scientists at the U.S. Department of Energy's Brookhaven National Laboratory and colleagues in Norway suggests that the benefits of moderately increased exposure to sunlight - namely the production of vitamin D, which protects against the lethal effects of many forms of cancer and other diseases - may outweigh the risk of developing skin cancer in populations deficient in vitamin D. The study will be published online in the Proceedings of the National Academy of Sciences the week of January 7, 2008.

"We know that solar radiation is the leading cause of skin cancer," said communicating author Richard Setlow, a Senior Biophysicist Emeritus at Brookhaven and a well-known expert on the link between solar radiation and skin cancer. Setlow's group was the first to establish that ultraviolet A (UVA) radiation and visible light are the primary causes of malignant melanoma, the deadliest form of skin cancer. He and his colleagues emphasize that people need to protect themselves from the harmful effects of sun exposure.

But solar radiation is also a major, if not the main, source of vitamin D in humans. In the presence of sunlight, the body converts certain precursor chemicals to active vitamin D.

"Since vitamin D has been shown to play a protective role in a number of internal cancers and possibly a range of other diseases, it is important to study the relative risks to determine whether advice to avoid sun exposure may be causing more harm than good in some populations." The concern, he says, is particularly great in populations from northern latitudes, such as Scandinavia, where sun exposure is extremely limited.

In the current study, Setlow and his colleagues used a model incorporating information on solar radiation intensity and a vertical cylinder shape to represent the human body's skin surface to calculate the relative production of vitamin D via sunlight as a function of latitude, or distance from the equator. The cylindrical model more realistically represents human body sun exposure than flat surface exposure measurements used in previous models. The scientists also examined the incidence of and survival rates for various forms of cancer by latitude.

According to the calculations, people residing in Australia (just below the equator) produce 3.4 times more vitamin D as a result of sun exposure than people in the United Kingdom, and 4.8 times more than people in Scandinavia.

"There is a clear north-south gradient in vitamin D production," Setlow says, "with people in the northern latitudes producing significantly less than people nearer the equator."

In populations with similar skin types, there is also a clear increase in the incidence of all forms of skin cancer from north to south. "This gradient in skin cancer rates indicates that there is a true north-south gradient in real sun exposure," Setlow says.

The scientists also found that the incidence rates of major internal cancers such as colon cancer, lung cancer, and cancers of the breast and prostate also increased from north to south. However, when the scientists examined the survival rates for these cancers, they found that people from the southern latitudes were significantly less likely to die from these internal cancers than people in the north.

"In previous work, we have shown that survival rates for these cancers improve when the diagnosis coincides with the season of maximum sun exposure, indicating a positive role for sun-induced vitamin D in prognosis - or at least that a good vitamin-D status is advantageous when combined with standard cancer therapies," Setlow says. "The current data provide a further indication of the beneficial role of sun-induced vitamin D for cancer prognosis."

So, how can people get the benefits of vitamin D without running the risk of deadly skin cancer"

"As far as skin cancer goes, we need to be most worried about melanoma, a serious disease with significant mortality," Setlow says.

Melanoma is triggered by UVA (the long UV wavelengths) and visible light. Vitamin-D production in the body, on the other hand, is triggered by UVB (the short UV wavelengths at the earth's surface). "So perhaps we should redesign sunscreens so they don't screen out as much UVB while still protecting us from the melanoma-inducing UVA and visible light," Setlow says.

Increased UVB exposure may result in an increase in non-melanoma skin cancers. But these are relatively easy to cure and have very low mortality rates compared with the internal cancers vitamin D appears to protect against, Setlow adds.

Another option would be to increase vitamin D consumption while continuing to wear sunscreen. Vitamin D is easily accessible in many foods and liquids, such as cod liver oil and milk, and in dietary supplements.


'/>"/>

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
Source:Eurekalert

Related medicine news :

1. Nonhospital health-care workers at substantial risk of exposure to bloodborne pathogens
2. Fetal Alcohol Exposure May Prime Offspring for Alcoholism
3. Jefferson neuroscientists find early lead exposure impedes recovery from brain injury
4. Radiation Exposure of Pregnant Women More than Doubles in 10 Years
5. Westaim reduces ABCP exposure
6. Fetal Exposure to Arsenic Affects Genes
7. VIDEO from Medialink and EcoQuest: New Technology Reduces Exposure to MRSA Staph
8. Firing clay in unvented kilns may be a source of exposure to dioxins
9. Exposure to sunlight may decrease risk of advanced breast cancer by half
10. Low Lead Exposures Can Hurt Kidneys
11. Occupational exposures may be linked to death from autoimmune disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... , ... February 12, 2016 ... ... today announced a new initiative—the Siemens Foundation-PATH Ingenuity Fellowships—to develop the advanced ... will recruit top students from U.S. universities who will draw from Siemens’ ...
(Date:2/12/2016)... ... ... Each year, the American Physical Therapy Association (APTA) offers a Combined Sections Meeting. ... Almost 10,000 physical therapists across the country are expected to attend this annual convention ... field and network with their colleagues. As in years past, HydroWorx is proud ...
(Date:2/12/2016)... ... February 12, 2016 , ... The ThedaCare ... San Francisco General Hospital on April 5-7. The series is a multi-day, multi-workshop ... habits. The workshops cover a broad range of topics, including coaching skills, the ...
(Date:2/12/2016)... NC (PRWEB) , ... February 12, 2016 , ... AssureVest ... surrounding areas, is initiating a charity drive that will raise funds earmarked to purchase ... John C. Tayloe Elementary School. , “My school is in a low-income area and ...
(Date:2/12/2016)... ... February 12, 2016 , ... Young Asset ... celebrates the beginning of the latest charity campaign in their community enrichment program. ... Donations to this worthy cause are currently being accepted at: http://artexpressioninc.org/ . ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... LOUISVILLE, Ky. , Feb. 12, 2016 ... it has completed a $47.1 million Series ... investors Cormorant Asset Management, Hillhouse Capital Group ... investors Morningside Venture Investments, AJU IB Investment, ... will be used to further advance clinical ...
(Date:2/11/2016)... , Feb. 11, 2016 Stem cells are ... characterized by self-renewal and the capacity to differentiate into ... new discovery, as the first mouse embryonic stem cells ... not until 1995 that the first culturing of embryonic ... cells were not produced until 2006 As a result ...
(Date:2/11/2016)... , Feb. 11, 2016  Governor Andrew M. Cuomo ... create 1,400 jobs throughout Western New York ... with the SUNY Polytechnic Institute, includes a major expansion ... in Buffalo , as well as ... facility in Dunkirk . The combined ...
Breaking Medicine Technology: