Navigation Links
More reasons to keep this New Year's weight loss resolution uncovered by Ben-Gurion U researchers
Date:12/21/2011

BEER-SHEVA, Israel Long-term healthy dietary interventions frequently induce a rapid weight decline, mainly in the first four to six months, followed by weight stabilization or regain, despite continued dieting. The partial regain may discourage people from adhering to healthier habits, but research now shows that improvements to health remain even if weight is regained.

The study recently released online in Diabetes Care (Print: February 2012) identified two distinct biomarker patterns that correspond to weight change, one of which continues to improve with time.

The study was conducted among 322 participants during the two-year Dietary Intervention Randomized Controlled Trial (DIRECT) performed by Ben-Gurion University of the Negev at the Nuclear Research Center Negev, Israel (New England Journal of Medicine). The population was randomized to three different, but healthy interventions: low-fat, Mediterranean or low-carbohydrate diets, and unprecedented adherence rates were maintained throughout the entire two-year period.

According to BGU Faculty of Health Sciences Prof. Assaf Rudich, "This study tells us that we may all have tunnel vision on weight when it comes to healthy dieting. Although maintaining ideal body weight is linked to better health, when it comes to adopting healthier dietary habits in mild to moderately obese people, there are benefits beyond weight loss, such as decreasing inflammatory tone and elevating the 'good cholesterol' HDL."

Rudich explains that switching to healthier dieting extends benefits beyond the single outcome of weight loss. In fact, important improvements that likely signify decreased risk for cardiovascular disease occur even despite weight regain, as long as dieting continues.

The researchers identified two distinct patterns:

"Pattern-A" includes biomarkers [insulin, triglycerides, leptin, chemerin, monocyte-chemotactic-protein-1(MCP-1), and retinol-binding-protein-4(RBP4)] whose dynamics tightly corresponded to changes in body weight. They significantly improved during the first six months of the "rapid weight loss phase." Then, unfortunately, they significantly trended in the opposite direction once participants started to regain weight during months 7-24 (the "weight maintenance/regain phase").

"Pattern B" that includes high-molecular-weight (HMW) [adiponectin, HDL-cholesterol, high-sensitive C-reactive protein (hsCRP), fetuin-A, progranulin, and vaspin], which displayed a continued, cumulative improvement throughout the intervention, despite the partial weight regain observed during months 7-24 of continued dieting, a totally different pattern of biomarkers.

These patterns were similar, although of different magnitude, across the low-carb, Mediterranean and low-fat diets.

Along the same line of continued benefit of adopting healthier dietary habits, the research team published an article last year in Circulation (a journal of the American Heart Association) that participants in DIRECT showed regression of the atherosclerotic plaque in their carotid artery, a process underlying a large percentage of the cases of stroke. Regression of atherosclerosis was previously only demonstrated with medications or with rather extreme dietary regimens.

According to Prof. Iris Shai, principal investigator of DIRECT, these findings contain a strong message for the public. A researcher at BGU's S. Daniel Abraham International Center for Health and Nutrition in the Department of Epidemiology, Shai says that, "Switching to a healthy lifestyle is a long-term strategy that should be done moderately but persistently. There are no magic shortcuts," she says.

"There is no doubt that moderate weight loss is an important goal for specific populations, and losing weight will indeed improve several markers that are rather tightly related to fat mass, such as triglycerides, insulin and leptin. These, however, will tend to change similarly to weight dynamics.

"Yet, it is encouraging that adhering to a healthy diet per-se will continue to improve other blood biomarkers, some of which quite strongly associate with improved cardio-metabolic health, likely because they reflect adipose tissue and other organ function, such as HDL-c, adiponectin and CRP. Such markers may signify long-term effects of the initial weight loss, or, maybe even more promisingly, reveal to us the capacity of healthier dietary habits to reverse obesity-associated adipose tissue and liver dysfunction."


'/>"/>
Contact: Andy Lavin
andrewlavin@alavin.com
516-944-4486
American Associates, Ben-Gurion University of the Negev
Source:Eurekalert

Related medicine news :

1. A Thousand New Reasons to Love Uni K Wax Centers Earn 5,000 Points for Referring A Friend New Rewards Program and New Centers
2. Study examines reasons patients with early stage lung cancer do not have surgery
3. Studies of womens attitudes to social egg freezing find reasons differ with age
4. Study Examines Reasons Some Black Men Avoid Doctors
5. More reasons to be nice: Its less work for everyone
6. Georgetown research identifies key reasons racial disparities exist in emergent stroke treatment
7. Survey reveals reasons doctors avoid online error-reporting tools
8. Internists to reveal top 10 reasons why Congress should repeal the SGR now
9. Should nuns be given the pill for health reasons?
10. “Hearts and Minds” Education Program Launched: On Average, People with Mental illness Live 25 Years Less than Other Americans
11. The Foundation of the American Academy of Ophthalmology's Museum of Vision Celebrates 30 Years of Preserving Ophthalmic Heritage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... To better understand the ... research award to examine gender differences in lung cancer. Today, the Lung Association announced ... Lung Cancer in Women Award, funded by the American Lung Association’s LUNG FORCE initiative, ...
(Date:5/24/2016)... ... , ... Jericho Project has named LaToya Williams-Belfort to the position of Chief ... and communications for the nationally-acclaimed nonprofit, working closely with CEO Tori Lyon and the ... at its roots. , “LaToya Williams-Belfort is joining Jericho at an exciting time ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... at Sentara Northern Virginia Medical Center located in Woodbridge, VA. The project ... services into a single site. , The new 2 story building houses the ...
(Date:5/24/2016)... ... 24, 2016 , ... Regenerative Medicine is being transformed by ongoing research and ... protocols and patient results as have been achieved with Okyanos Cell Therapy ... of care for patients worldwide. , As the Medical Advisory Chairman at Okyanos, Eric ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... Boyd Industries, ... Concealed Delivery Unit® (CDU), a groundbreaking new product for pediatric dentistry , at ... Dentistry in San Antonio, TX May 26-29. The Concealed Delivery Unit keeps dental hand ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... According to a new ... Product (Wheelchair, Scooters, Medical Beds, Bathroom Safety, Mechanical, ... Wound), Accessories (Lifting, Transfer) & by End User ... MarketsandMarkets, the patient handling equipment market is expected ... a CAGR of 10.5% during the forecast period ...
(Date:5/23/2016)... YORK , May 23, 2016 ... Spectrometry Market Size, Share, Development, Growth and Demand ... (Hybrid, Single and Other), by Application (Drug Discovery ... by End Users (Pharmaceuticals, Life Science and Biotechnology, ... by P&S Market Research, the global mass ...
(Date:5/23/2016)... , UAE, May 23, 2016 ... the importance of Precision Medicine and the role ...     The First International Conference of ... under the distinguished patronage and presence of Sheikh Nahyan bin ... conference focused in Precision Medicine, which helps provide personalized medicine ...
Breaking Medicine Technology: