Date:8/30/2012

on anthracycline alone compared with no chemotherapy, yet similar to results of previous clinical trials. But the overall risk of these cardiac problems was even greater among women who used trastuzumab alone. And the risk among women who used both anthracycline and trastuzumab was greater than previously reported. Also, women receiving anthracyclinewith or without trastuzumabtended to be younger and without other illnesses; by contrast, women on trastuzumab alone tended to be older and have more illnesses.

Chemotherapy can cause cardiac problems through several mechanisms, Ms. Bowles added. "These drugs are toxic," she said. "They kill cancer cells, and sometimes kill other cells in the body, too. These drugs are still important for women with breast cancer to use because we know they improve survival. But as with any drug, people need to be aware of the risks, too."

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Contact: Rebecca Hughes hughes.r@ghc.org 206-287-2055 Group Health Research Institute Source:Eurekalert

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