Navigation Links
More heart problems with 2 chemo drugs for breast cancer
Date:8/30/2012

SEATTLEWomen who have breast cancer and are treated with two chemotherapy drugs may experience more cardiac problems like heart failure than shown in previous studies, according to a new Cancer Research Network study by Group Health researchers and others in the Journal of the National Cancer Institute.

The study is significant because more and more women are surviving longer with breast cancer, so it's becoming a chronic disease, said lead author Erin Aiello Bowles, MPH, an epidemiologist at Group Health Research Institute. Breast cancer is one of the most common cancers in the United States, with an estimated 232,620 new diagnoses in 2011. Often the cure is problematic, as when chemotherapy causes other health problemsas shown in this study.

Ms. Bowles and her colleagues estimated real-world use of anthracycline and trastuzumab use and their associations with heart failure and cardiomyopathy. Earlier clinical trials had shown that women treated for breast cancer with the drugs anthracycline or trastuzumab were at increased risk for heart failure, cardiomyopathy, or both. Like most clinical trials, the earlier clinical trials excluded large categories of patients, including elderly women and those with other health problems, such as existing heart disease. Excluding these women could make the studies miss what happens in the general population.

"We tried to take a broader look by estimating the risk of heart failure in a more general population," Ms Bowles said. "We looked at all the women in a population with breast cancer, not selected ones. Our study shows that people who are not generally eligible for clinical trialsolder women and those with existing heart failuredo receive these drugs in real life."

In the population-based, retrospective cohort study of 12,500 women diagnosed with invasive breast cancer, the overall risk of developing either heart failure or cardiomyopathy was significantly higher in women on anthracycline alone compared with no chemotherapy, yet similar to results of previous clinical trials. But the overall risk of these cardiac problems was even greater among women who used trastuzumab alone. And the risk among women who used both anthracycline and trastuzumab was greater than previously reported. Also, women receiving anthracyclinewith or without trastuzumabtended to be younger and without other illnesses; by contrast, women on trastuzumab alone tended to be older and have more illnesses.

Chemotherapy can cause cardiac problems through several mechanisms, Ms. Bowles added. "These drugs are toxic," she said. "They kill cancer cells, and sometimes kill other cells in the body, too. These drugs are still important for women with breast cancer to use because we know they improve survival. But as with any drug, people need to be aware of the risks, too."


'/>"/>
Contact: Rebecca Hughes
hughes.r@ghc.org
206-287-2055
Group Health Research Institute
Source:Eurekalert  

Related medicine news :

1. Heart Attacks, Strokes Jumped After Japan Earthquake, Study Finds
2. Belly Fat May Hit Your Heart the Hardest
3. Early Stenting Best for Some Heart Patients: Study
4. 2 Common Blood Pressure Meds Fare Equally in Preventing Heart Woes
5. Electronic Cigarettes Have Slight Impact on Heart: Study
6. Energy drinks improve heart function
7. Renal denervation gives better outcomes than drugs in advanced heart failure
8. New Blood Thinner Effient No Better Than Plavix at Preventing Heart Trouble: Study
9. Study examines factors associated with improvement in survival from heart attack in France
10. Spouses of Heart Attack Victims May Face Heightened Depression Risk
11. 2 Tests May Improve Heart Patients Care, Studies Suggest
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
More heart problems with 2 chemo drugs for breast cancer
(Date:6/24/2017)... ... 24, 2017 , ... The weather is heating up and the days are ... should be aware that the summer months provide more than warmer temperatures that are ... can be negatively affected from direct exposure to the sun. When it comes to ...
(Date:6/23/2017)... , ... June 23, 2017 , ... By scoring 100% ... ninth consecutive four-star rating from premier online charity evaluator, Charity Navigator, validating ANRF's work ... 1% of all charities reviewed by Charity Navigator and earns ANRF a spot on ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... ... plastic surgeon practicing in Newburgh, New York, has recently begun offering three new ... to offering the best cutting-edge procedures and reducing downtime, Dr. Rubinstein is excited ...
(Date:6/23/2017)... Hills, CA (PRWEB) , ... June 23, 2017 , ... ... plane facelift . Dr. Talei has come up with a proprietary technique that ... releases and lifts tissues that have dropped. For all ages, patients can expect to ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... MD ... Florida. This is MD Now’s 28th facility overall and marks the urgent care center's ... located one mile North of The Falls shopping mall. The new clinic offers a ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)...  Hill-Rom Holdings, Inc. (NYSE: HRC), will host its fiscal ... July 28, 2017, beginning at 7:30 a.m. (CDT) / 8:30 ... To participate in the conference call, dial (877) 304-8969 (domestic) ... least 10 minutes prior to the start to allow time ... Webcast: A simultaneous webcast of the ...
(Date:6/16/2017)... , June 16, 2017  Exactly 50 years ago ... off what later became known as the San Francisco "Summer ... ) is unveiling two radical innovations in strategic market research ... This announcement marks the beginning of Northern Light,s "Summer of ... ...
(Date:6/14/2017)... -- In 2016, Embodied Labs took top prize ... came away with $25,000 in seed-fund investment. Embodied Labs ... "entering the life of another" and by the Journal ... medical professionals in an entirely new dimension." Building upon ... for the Department of Education,s EdSimChallenge, where they received ...
Breaking Medicine Technology: