Navigation Links
More 'functional' DNA in genome than previously thought
Date:12/11/2007

Surrounding the small islands of genes within the human genome is a vast sea of mysterious DNA. While most of this non-coding DNA is junk, some of it is used to help genes turn on and off. As reported online this week in Genome Research, Hopkins researchers have now found that this latter portion, which is known as regulatory DNA and contributes to inherited diseases like Parkinsons or mental disorders, may be more abundant than we realize.

By conducting an exhaustive analysis of the DNA sequence around a gene required for neuronal development, Andrew McCallion, Ph.D., an assistant professor in the McKusick-Nathans Institute of Genetic Medicine, and his team found that current computer programs that scan the genome looking for regulatory DNA can miss more than 60 percent of these important DNA regions.

The current methods find regulatory sequences by comparing DNA from distantly related species, under the theory that functionally important regions will appear more similar in sequence than non-functional regions. The problem with this approach, we have discovered, says McCallion, is that its often throwing the baby out with the bath water. So while we believe sequence conservation is a good method to begin finding regulatory elements, to fully understand our genome we need other approaches to find the missing regulatory elements.

McCallion had suspected that using sequence conservation would overlook some regulatory DNA, but to see how much, he set up a small pilot project looking at the phox2b gene; he chose this gene both because of its small size and his interest in nerve development (phox2b is involved in forming part of the brain associated with stress response as well as nerves that control the digestive system).

The researchers created what they call a tiled path, cutting up the DNA sequence around the phox2b gene into small pieces, then inserted each piece into zebrafish embryos along with a gene for a fluorescent
'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers uncover novel mechanism that balances the sizes of functional areas in the brain
2. Creating Effective Cross-Functional Teams for Pharmaceutical Commercialization Success
3. Dysfunctional families and bad neighborhoods may worsen asthma in children and adolescents
4. Martek Wins German DHA Patent Infringement Actions Against Lonza and One of Nutrinovas Customers in Suits Relating to DHA Product Marketed for Use in Functional Foods and Dietary Supplements
5. Phase I pharmacokinetic study of ECO-4601, a novel bifunctional targeting agent
6. NetSuite Partners Introduce New Vertical Versions of NetSuite and Horizontal Extensions to Core NetSuite Functionality
7. Exclusive American Council on Exercise (ACE) Research Study Proves Functional Fitness Really Works
8. CJ Transforms His Functional Fitness Program Into an Additional Resource for the Hurricane Katrina Survivors
9. One Species Genome Found Within Another
10. Genome Area Linked to Rheumatoid Arthritis
11. Researchers provide genetic associations from a genome-wide scan for cardiovascular disease traits

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/30/2009)..., , GAINESVILLE, Fla., Nov. 30 /PRNewswire/ -...aCAD marks the availability of the first FDA-clear...etection and analysis by a radiologist of suspicio...ally unveiled at the Radiological Society of North...eloped in partnership with leading experts in brea...
(Date:11/30/2009)...o lab studies report safe transplant results in an...ews) -- Two new studies in animals suggest that st... cord blood could help treat some lung and heart d...stem cells can differentiate into a long list of d... Soon Park of the Samsung Medical Center in Seoul,...
(Date:11/30/2009)..., , WASHINGTON, Nov. 30 - Salo...A Cause" on Monday, December 7(th) to raise funds ...ildhood terminal diseases. All proceeds from each ...hildren,s Research Hospital. ,, Salon Leau has...rs. The salon is owned by LoAnn Lai, widely recogn...
(Date:11/30/2009)..., , PHILADELPHI.../ -- , - Exclusive Updates From Elsevier,...e Reform and ARRA Momentum , Elsevier, a ...n as well,as web-based and electronic health recor...w online resource center for American Recovery and...
(Date:11/30/2009)...UPTON, NY When asked to inhibit their response to...re, on average, able to suppress activity in brain...w study at the U.S. Department of Energy,s Brookha...hed in an upcoming issue of NeuroImage , suggest ... these inhibitory responses could help cocaine abu...
Breaking Medicine News(10 mins):Health News:New Breast MRI Technology Enables Enhanced Breast Cancer Detection 2Health News:New Breast MRI Technology Enables Enhanced Breast Cancer Detection 3Health News:Georgetown Hair Salon Helps St. Jude Find A Cure 2Health News:Elsevier Launches New Online ARRA Resource Center and Clinical Decision Support Blog 2Health News:Elsevier Launches New Online ARRA Resource Center and Clinical Decision Support Blog 3Health News:Elsevier Launches New Online ARRA Resource Center and Clinical Decision Support Blog 4Health News:Brain scan study shows cocaine abusers can control cravings 2Health News:Brain scan study shows cocaine abusers can control cravings 3
... The frequent spread of certain cancers to lymph ...apy that damages the lymphatic system and can caus...tion that often increases susceptibility to infect...ial growth factor-C (VEGF-C) to replace excised mo...
...RAZER, Pa., Dec. 3 Cephalon, Inc. (Nasdaq:,CEPH) ...stration (FDA) has,accepted and granted priority r...HCl) New Drug Application (NDA) for the first-line...,cases diagnosed every year in the United States. ...
... Springhill Medical Center Latest Healthcare Organ... Information Solution; Activation Completed Ahead ..., LAS VEGAS, Dec. 3 At the 2007 American,Society...et momentum for Sunrise Pharmacy(TM) with seven cl...
...ponsored by The Beryl Institute, Conference to Fea...r in Dallas, March 26-28, 2008, DALLAS, Dec. 3 T...its 2008 conference "The Power of Impressions" to ...erence is,the Ritz-Carlton Leadership Center, whic...
...rogram locks in rates while increasing amount avai...e years at no additional cost, DAYTON, Ohio, Dec....l maximum dollars when you renew your contract and...ximum,Advantage feature that offers their Preferre...
...rowing U.S. Customer Base Surpasses 660 Sites, DE... Bulletin Board: GLOB), an international e-Health,...ounced that its Wyndgate,Technologies(R) division ...orial Hospital (Sheridan) joins a growing,customer...
Other Medicine News:Health News:Lymphatic vessel and lymph node function are restored with growth factor treatment 2Health News:Lymphatic vessel and lymph node function are restored with growth factor treatment 3Health News:TREANDA New Drug Application for the Treatment of Chronic Lymphocytic Leukemia Granted Priority Review Status by FDA 2Health News:TREANDA New Drug Application for the Treatment of Chronic Lymphocytic Leukemia Granted Priority Review Status by FDA 3Health News:TREANDA New Drug Application for the Treatment of Chronic Lymphocytic Leukemia Granted Priority Review Status by FDA 4Health News:TREANDA New Drug Application for the Treatment of Chronic Lymphocytic Leukemia Granted Priority Review Status by FDA 5Health News:Eclipsys Announces Strong Market Momentum for Sunrise Pharmacy 2Health News:Eclipsys Announces Strong Market Momentum for Sunrise Pharmacy 3Health News:Eclipsys Announces Strong Market Momentum for Sunrise Pharmacy 4Health News:Eclipsys Announces Strong Market Momentum for Sunrise Pharmacy 5Health News:'The Power of Impressions' 2008 Conference to Explore Customer Service in Healthcare 2Health News:Superior Dental Care Alliance Launches Maximum Advantage Program 2Health News:Global Med Technologies(R), Inc. Adds Wyoming Hospital to Growing Customer Base 2Health News:Global Med Technologies(R), Inc. Adds Wyoming Hospital to Growing Customer Base 3
(Date:11/30/2009)...RK, Nov. 30 Reportlinker.com annou...e in its catalogue: ,, Decubitus Ulcer Treatme...tp://www.reportlinker.com/p0164283/Decubitus-Ulcer...ml ,, Decubitus Ulcers are lesions resulting ...the patient,s bodyweight. Pressure ulcer treatment...
(Date:11/30/2009)...LLS, Mich., Nov. 30 eHealthSource....ted exclusively to products approved for Flexible ...A) claims. The site is also the first to exclusiv...s, saving shoppers up to 75 percent on everyday he...wo common healthcare headaches - high costs and co...
(Date:11/30/2009).... 30 MedPro Imaging, a premium pro... will showcase leading ultrasound solutions includ...X300 Premium Edition during the company,s debut at...) conference, being held in Chicago November 29 - ...arkets ultrasound products and services in 17 coun...
Breaking Medicine Technology:Reportlinker Adds Decubitus Ulcer Treatment Products - A Worldwide Market Review 2Reportlinker Adds Decubitus Ulcer Treatment Products - A Worldwide Market Review 3Reportlinker Adds Decubitus Ulcer Treatment Products - A Worldwide Market Review 4Reportlinker Adds Decubitus Ulcer Treatment Products - A Worldwide Market Review 5Reportlinker Adds Decubitus Ulcer Treatment Products - A Worldwide Market Review 6eHealthSource.com Launches Online Shopping Site Dedicated to Over-the Counter Medications Approved for FSA/HSA Claims 2MedPro Imaging to Showcase Leading New and Refurbished Ultrasound Solutions at RSNA 2 24450 000 Awarded for Innovative Asthma Research Into Death by Drowning in Mucus 57997 1 24450 000 Awarded for Innovative Asthma Research Into Death by Drowning in Mucus 57997 2Fall Chores Spark Safety Advice From Orthopaedic Surgeons 57995 1Fall Chores Spark Safety Advice From Orthopaedic Surgeons 57995 2Fall Chores Spark Safety Advice From Orthopaedic Surgeons 57995 3Reportlinker Adds Pharmaceutical Outsourcing Opportunities Post Launch 3A Contract Manufacturing and Contract Sales and Marketing 3rd Edition Report 57993 1Reportlinker Adds Pharmaceutical Outsourcing Opportunities Post Launch 3A Contract Manufacturing and Contract Sales and Marketing 3rd Edition Report 57993 2Reportlinker Adds Pharmaceutical Outsourcing Opportunities Post Launch 3A Contract Manufacturing and Contract Sales and Marketing 3rd Edition Report 57993 3Reportlinker Adds Pharmaceutical Outsourcing Opportunities Post Launch 3A Contract Manufacturing and Contract Sales and Marketing 3rd Edition Report 57993 4Reportlinker Adds Pharmaceutical Outsourcing Opportunities Post Launch 3A Contract Manufacturing and Contract Sales and Marketing 3rd Edition Report 57993 5Reportlinker Adds Pharmaceutical Outsourcing Opportunities Post Launch 3A Contract Manufacturing and Contract Sales and Marketing 3rd Edition Report 57993 6Reportlinker Adds Pharmaceutical Outsourcing Opportunities Post Launch 3A Contract Manufacturing and Contract Sales and Marketing 3rd Edition Report 57993 7Reportlinker Adds Pharmaceutical Outsourcing Opportunities Post Launch 3A Contract Manufacturing and Contract Sales and Marketing 3rd Edition Report 57993 8Reportlinker Adds Pharmaceutical Outsourcing Opportunities Post Launch 3A Contract Manufacturing and Contract Sales and Marketing 3rd Edition Report 57993 9Reportlinker Adds Pharmaceutical Outsourcing Opportunities Post Launch 3A Contract Manufacturing and Contract Sales and Marketing 3rd Edition Report 57993 10Reportlinker Adds Pharmaceutical Outsourcing Opportunities Post Launch 3A Contract Manufacturing and Contract Sales and Marketing 3rd Edition Report 57993 11Reportlinker Adds Pharmaceutical Outsourcing Opportunities Post Launch 3A Contract Manufacturing and Contract Sales and Marketing 3rd Edition Report 57993 12
...Phase II trial of a single,intraoperative administ...gnificantly reduced pain with activity in the firs...nerally greatest, compared to conventional treatme...uble-blind study were presented,in a poster at the... New York,City today, by lead investigator Richard...
... Texas, Dec. 12 A,groundbreaking study developed ...e significantly affected by the steady stream of i...is study surveyed over 2,400 girls ages 8-18. Som...that nearly 30% of the girls,surveyed believed tha...m of,breast cancer, and more than 20% of girls bel...
Other Medicine Technology:Positive Phase II Study of Pacira's EXPAREL(TM) (DepoBupivacaine) in Hernia Repair Presented at the Postgraduate Assembly in Anesthesiology (PGA) 2Positive Phase II Study of Pacira's EXPAREL(TM) (DepoBupivacaine) in Hernia Repair Presented at the Postgraduate Assembly in Anesthesiology (PGA) 3Positive Phase II Study of Pacira's EXPAREL(TM) (DepoBupivacaine) in Hernia Repair Presented at the Postgraduate Assembly in Anesthesiology (PGA) 4New Research Reveals Unforeseen Side Effect of the Breast Cancer Movement 2
...utostat™II Rheumatoid Factor IgM enzyme linked...id Factor IgM (RF IgM). Enzyme-linked immunosorben...of specific IgM Rheumatoid Factor in human serum. ...aid in the diagnosis of Rheumatoid Arthritis when ...
ACUVUE OASYS with HYDRACLEAR™ PLUS
Carriazo-Pendular
...ctor I or somatomedin-C, is a peptide highly depen...ting activity. IGF-I is transported in serum by se...owth disorders, measurements of IGF-I are a useful.... A normal plasma or serum IGF-I concentration is ...
Medicine Products: