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More evidence suggests diabetes drug may be dangerous
Date:12/11/2007

TORONTO, Dec. 11 /PRNewswire/ - A popular class of drugs for treating type 2 diabetes is under scrutiny again. A new Canadian study released by the Institute for Clinical Evaluative Sciences (ICES) finds that drugs such as Avandia increase the risk of heart failure, heart attacks and death.

Published in the December 12th issue of JAMA, ICES scientists looked at the glitazone class of drugs including rosiglitazone (Avandia) and pioglitazone (Actos) in the first real world population-based study of its kind. All Ontario residents aged 65 years or older, treated with at least one oral diabetic medication were followed between 2002 and 2006. "The necessity for evaluating diabetes drug outcomes in older patients is reinforced by the fact that seniors have the highest prevalence of diabetes and represent over 40% of the population with the disease," says lead author and ICES researcher, Dr. Lorraine Lipscombe. "We cannot be certain whether similar effects would be seen in younger patients. Our study represents a concern for older patients taking these drugs who are at higher risk for adverse cardiac outcomes."

The ICES study explored three distinct outcomes using Ontario health care databases: hospital visits for congestive heart failure, hospital visits for heart attacks and death from any cause, and looked at exposure to specific diabetes drugs in seniors. Compared to other diabetes pills glitazones (Avandia & Actos ) are associated with the following results:

- 60% relative increase in heart failure, 40% relative increase in

heart attacks, 30% relative increase in death.

- This translates into an estimated 3 additional episodes of heart

failure, 4 additional heart-attacks and 5 additional deaths for every

100 individuals taking these drugs, over a 4 year period in a high-

risk older population.

- Risk predominantly among those taking rosiglitazone (Avandia).

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SOURCE Institute for Clinical Evaluative Sciences
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