Navigation Links
More blood vessels in hormone-resistant prostate tumors
Date:12/15/2009

Patients with advanced prostate cancer are often treated with hormones, but when the tumours start growing again they have more and different blood vessels, reveals a thesis from the Sahlgrenska Academy, at the University of Gothenburg, Sweden. This discovery paves the way for new treatments for hormone-resistant prostate cancer.

Late in the course of the disease, when the prostate cancer has spread, most patients are given hormone therapy. This reduces the production of the male sex hormone and the tumour shrinks.

"The problem is that the effect is transient," says molecular biologist Helne Gustavsson, who wrote the thesis. "Sooner or later the tumour will develop resistance to the hormone treatment and then the cancer will continue to grow, often as secondary tumours in the bones.

Tumours have to make new blood vessels if they are to grow and spread in the body. The thesis shows that the tumours that have relapsed after a patient has been given hormone therapy contain more blood vessels. The blood vessels often also look different to how they looked during the earlier stages of the disease.

Another interesting finding is that levels of a protein known as ADAMTS1 are lower in these aggressive tumours. This protein is known to inhibit the growth of blood vessels. Low levels of the protein in the tumours are associated with more blood vessels and a greater spread of the cancer.

"If we can prevent the tumour from making new blood vessels, we can also prevent the cancer from spreading," says Gustavsson. "Now that we have a better understanding of how the formation of blood vessels is controlled in this stage of prostate cancer, we are in a better position to develop medicines that suppress the formation of new vessels in hormone-resistant prostate cancer."

The research team at the Sahlgrenska Academy will now assess how these changes affect the function of the blood vessels and their sensitivity to different treatments.


'/>"/>

Contact: Helne Gustavsson
helene.gustavsson@urology.gu.se
46-313-422-928
University of Gothenburg
Source:Eurekalert

Related medicine news :

1. Specific antagonism lowers blood pressure
2. Restricting Blood Flow May Help Heart Bypass Patients
3. FDA Updates Prescription Guidelines for Blood Thinner
4. Doctors Often Miss High Blood Pressure in Kids
5. Back to School Means Return of School Blood Drives
6. Blood-flow detector software show promise in preventing brain damage
7. FDA Approves New Roche West Nile Virus Blood Screening Test
8. Australian-led international study shows blood pressure drugs cut death rate in type 2 diabetes
9. Laser blasts viruses in blood
10. Study Demonstrates Marteks Algal DHA Oil Improves Blood Triglyceride Lipid Levels
11. LifeMasters Provides Tips for Maintaining a Healthy Blood Cholesterol Level
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... 28, 2017 , ... AutismOne announced the Board Certified in ... Medicine and available for application on Saturday, May 27, 2017, following Thursday, Friday, ... Springs. , Ed Arranga, president of AutismOne, stated: "Many of the modalities termed ...
(Date:3/28/2017)... ... 2017 , ... Public relations pros work hard to earn placements and ... While many results are clear, much of PR is hard to quantify. Goal-setting and ... to measurement, firms should always take an all-inclusive approach that takes both traditional and ...
(Date:3/28/2017)... ... 2017 , ... With expansion and efficiency in mind, Patten Seed Company completed ... processing plant opened in Marshallville in 2006, and a bagging and shipping facility has ... transition of Patten Seed operations to the Middle Georgia location from their previous home ...
(Date:3/28/2017)... ... 2017 , ... Oily skin is a common and unwelcomed occurrence in people of all ages, ... to offer to the discussion of dealing with excess skin oil. “Oily skin is a ... remedies that can help remove the oily shine while keeping the skin fresh and clean,” ...
(Date:3/28/2017)... ... 28, 2017 , ... Nurse practitioners and physician assistants are ... in the healthcare workforce, according to a survey recently released by PracticeMatch ... candidate leads to healthcare employers of physicians and advanced practice clinicians. , Only ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... Calif. , March 27, 2017  Cryoport, Inc. ... that it intends to offer shares of common stock ... registration statement on file with the Securities and Exchange ... and other conditions, and there can be no assurance ... completed, or as to the actual size or terms ...
(Date:3/27/2017)... , March 27, 2017 ... attendees and more than 600 exhibitors from 70 ... opportunities and solutions that will advance the medical ... 2017 at the Messe Stuttgart, Stuttgart, ... medical technology platform showcasing the key trends and ...
(Date:3/27/2017)... , March 27, 2017  Sanderling Ventures, ... by Ethicon, a division of Johnson & Johnson. Torax ... for the treatment of gastro-esophageal reflux disease (GERD). ... augmentation (MSA) technology and the procedure is currently ... Torax Medical was founded by Sanderling ...
Breaking Medicine Technology: