Navigation Links
More Research Points to Long-Term Ills With Bone Drugs
Date:5/21/2012

MONDAY, May 21 (HealthDay News) -- Adding more weight to concerns about possible long-term dangers of osteoporosis drugs, a new study finds that people who take the drugs, known as bisphosphonates, may be at increased risk for atypical fractures of the thigh bone (femur).

Osteoporosis is a bone-thinning disease that is common in older women. An atypical femoral fracture is an unusual type of break that often occurs spontaneously, without any major leg injury.

In the new study, Swiss researchers looked at 477 patients, aged 50 and older, who were hospitalized with a femoral fracture. Of those patients, 39 had atypical fractures and 438 had a classic fracture (a more common fracture with a typical pattern).

These groups were compared with 200 people without femoral fractures. The findings were published online May 21 in the journal Archives of Internal Medicine.

The investigators found that 82 percent of the patients with atypical fractures had been treated with bisphosphonates, such as Actonel or Fosamax, compared with about 6 percent of the patients with classic fractures.

But compared to patients without fractures, use of bisphosphonates was associated with a 47 percent reduction in the risk of a classic fracture.

The researchers compared duration of bisphosphonate treatment versus no treatment and found that the odds ratio for an atypical fracture versus a classic fracture was 35 to 1 for less than two years of treatment, 46 to 9 for two to five years of treatment, 117 to 1 for five to nine years of treatment, and 175 to 7 for more than nine years of treatment.

"In conclusion, we have demonstrated that the association between bisphosphonate treatment and the occurrence of atypical fractures of the femur is highly likely and that the duration of such treatment significantly correlates with augmented risk," Dr. Raphael Meier and colleagues from University Hospitals of Geneva and Faculty of Medicine in Geneva, concluded in a journal news release.

"However, the incidence rate was very low, and the absolute benefit to risk ratio of bisphosphonate use remains positive," the authors added.

While the study uncovered an association between bisphosphonate use and atypical fractures, it did not prove a cause-and-effect relationship.

In 2010, the U.S. Food and Drug Administration issued a warning about the possible risk of femur fractures from taking bisphosphonates over a long period of time.

More information

The National Osteoporosis Foundation has more about osteoporosis medicines.

-- Robert Preidt

SOURCE: Archives of Internal Medicine, news release, May 21, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Kessler Foundation scientists present cognitive research findings at MS dual symposium
2. AGA presents cutting-edge research during DDW®
3. Research With Dogs Points to Early Test for Arthritis
4. Dartmouth researchers investigate the cognitive effects of athlete head impacts
5. Fish Pedicure a Recipe for Bacterial Infection, Researchers Warn
6. Fox Chase researchers find no disparities in imaging before breast cancer surgery
7. More cutting-edge cancer research supported by industry
8. Mount Sinai presents treatment trends, vaccine research, prognosis data at ASCO
9. Researchers undertake radical new cancer survivorship study
10. Parents are happier than non-parents, new research suggests
11. Researchers make promising discovery in pursuit of effective lymphoma treatments
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
More Research Points to Long-Term Ills With Bone Drugs
(Date:5/6/2016)... KING OF PRUSSIA, PA and LONDON, UK (PRWEB) , ... May ... ... continues to earn accolades for his success in changing the way the pharmaceutical industry ... Power 100 list of the world’s most influential people in pharma, and he was ...
(Date:5/6/2016)... Chandler, AZ (PRWEB) , ... May 06, 2016 ... ... No Greater Odds, are scheduled to provide a unique keynote address at the ... documentary follows the inspirational stories of five community college students. Their stories—of complicated ...
(Date:5/6/2016)... ... ... A wide variety of national pet product manufacturers, companies and brands will gather for one ... 18 from noon to 8 p.m. at New York City’s Roger Smith Hotel. The event ... garden, outdoor and safety pet products in today’s marketplace. , Petrend Event showcases ...
(Date:5/6/2016)... Jupiter, FL (PRWEB) , ... May 06, 2016 ... ... it will feature AsedaSciences® in an upcoming episode, airing third quarter 2016, via ... with the vision of becoming a leader in optimized drug discovery through innovative ...
(Date:5/6/2016)... Pass, OR (PRWEB) , ... May 06, 2016 , ... ... eyes. In other seasons, when the weather is too cold, dry or hot, water ... the eyes can actually absorb moisture from the surrounding air. There’s only one problem, ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... 2016 Research and ... Multiple Myeloma Market and Competitive Landscape Highlights ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) ... Landscape Highlights 2016, provides comprehensive insights into ... Multiple Myeloma market valuations and forecast, Multiple ...
(Date:5/4/2016)... May 4, 2016 ... the  "Global Actinic Keratosis Market and Competitive ... offering.       (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... and Competitive Landscape Highlights 2016, provides comprehensive ... Keratosis epidemiology, Actinic Keratosis market valuations and ...
(Date:5/3/2016)... KANSAS CITY, Mo. , May 3, 2016 ... of Kansas Medical Center,s Institute for Advancing Medical ... develop and commercialize new drugs, diagnostics and medical ... organizations provides BioNovus Innovations with rights to license, ... "This partnership ...
Breaking Medicine Technology: