Navigation Links
More Kids Taking Antipsychotics for ADHD: Study
Date:8/7/2012

By Steven Reinberg
HealthDay Reporter

TUESDAY, Aug. 7 (HealthDay News) -- Use of powerful antipsychotic medications such as Abilify and Risperdal to control youngsters with attention-deficit/hyperactivity disorder (ADHD) and other behavior problems has skyrocketed in recent years, a new study finds.

Antipsychotics are approved to treat bipolar disorder, schizophrenia, other serious mental problems and irritability related to autism. But they don't have U.S. Food and Drug Administration approval for ADHD or other childhood behavior problems, and their use for this purpose is considered "off label."

"Only a small proportion of antipsychotic treatment of children (6 percent) and adolescents (13 percent) is for FDA-approved clinical indications," said lead researcher Dr. Mark Olfson, a professor of clinical psychiatry at Columbia University Medical Center in New York City.

"These national trends focus attention on the substantial and growing extent to which children diagnosed with ADHD and other disruptive behavioral disorders are being treated with antipsychotic medications," said Olfson.

The researchers found that doctor visits between 1993-1998 and 2005-2009 that involved a prescription of antipsychotic medication for children jumped sevenfold -- from 0.24 to 1.83 per 100 people. For teens, 14 to 20 years old, the rate rose from 0.78 to 3.76 per 100 people, and for adults, it just about doubled, from 3.25 to 6.18 per 100 people.

Many of the prescriptions for children were ordered by doctors who are not psychiatrists, the researchers found.

Although these drugs can deliver rapid improvement in children with severe conduct problems and aggressive behaviors, it is not clear whether they are helpful for the larger group of children with ADHD, he said. Nor has their long-term effect on children's developing brains been studied.

Olfson said most children and adolescents treated with antipsychotics are not receiving psychotherapy. "This suggests that more needs to be done to increase access and availability of psychosocial interventions," he said.

"Parent management training and cognitive problem-solving skills training are examples of effective but underused treatments for young people with disruptive behavioral problems," he said.

The study, published in the Aug. 6 online edition of the Archives of General Psychiatry, used data from the National Ambulatory Medical Care Surveys from 1993 to 2009. More than 484,000 people were included in total.

The researchers found prescriptions for antipsychotics increased for children and adults. But doctors prescribed more antipsychotics to children and adolescents (68 percent and 72 percent, respectively) than to adults (50 percent).

For children 13 and younger, the most prescribed drug was risperidone (Risperdal). Other drugs included aripiprazole (Abilify), quetiapine (Seroquel) and olanzapine (Zyprexa). Of these drugs, Abilify was most commonly prescribed to adolescents, aged 14 to 20, the study found.

All of these antipsychotics, developed since the 1990s, are considered "atypical" or second-generation antipsychotics.

For elderly patients, the FDA recently issued a Public Health Advisory about atypical antipsychotic medications after determining that death rates are higher for elderly people with dementia when taking atypical antipsychotics.

Dr. Peter Breggin, a psychiatrist from Ithaca, N.Y., and an outspoken critic of widespread antipsychotic use in children, said these drugs damage developing brains.

"We have a national catastrophe," said Breggin. "This is a situation where we have ruined the brains of millions of children."

In controlling behavior, antipsychotics act on the frontal lobes of the brain -- the same area of the brain targeted by a lobotomy, Breggin said.

"These are lobotomizing drugs," he added. "Of course, they will reduce all behavior, including irritability," he said.

Olfson's team found that most children treated with antipsychotic medications are diagnosed with ADHD, oppositional behavior and unspecified disruptive behavioral disorders.

Between 2005 and 2009, controlling "disruptive behavior" accounted for 63 percent of the reason antipsychotics were given to children and almost 34 percent for adolescents, the researchers found.

In contrast, bipolar disorder and depression were the most common reasons these drugs were prescribed to adults during that time period.

Simon Rego, director of psychology training at Montefiore Medical Center/Albert Einstein College of Medicine in New York City, said these drugs have serious side effects, including weight gain, diabetes and heart problems.

"But, perhaps even more important is the finding that a substantial majority of the child antipsychotic visits were for young people diagnosed with disruptive behavior disorders, for which there are currently no FDA-approved antipsychotic medications," he said.

Given the uncertain effects that antipsychotic medications have on cognitive (brain), social and physical development in children and adolescents, it may be necessary to reevaluate clinical practice patterns, Rego said.

Efforts to educate physicians about the safety and effectiveness of antipsychotic medications are also needed, he said.

More information

For more information on antipsychotics, visit the U.S. National Institute of Mental Health.

SOURCES: Mark Olfson, M.D., M.P.H., professor of clinical psychiatry, Columbia University, New York City; Simon A. Rego, Psy.D., director of psychology training, Montefiore Medical Center/Albert Einstein College of Medicine, New York City; Peter Breggin, M.D., psychiatrist, Ithaca, N.Y., author, Psychiatric Drug Withdrawal: A Guide for Prescribers, Therapists, Patients and their Families; Aug. 6, 2012, Archives of General Psychiatry, online


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Not taking gastroprotective drugs prescribed with anti-inflammatory medicines
2. Seniors Stop Taking Heart Drugs In Medicare Donut Hole
3. Taking Away Car Keys Can Be Tough for Older Drivers
4. Taking Anti-HIV Meds Prior to Exposure May Help Prevent Infection
5. Patients taking certolizumab pegol are twice as likely to achievE ACR20 compared to placebo
6. Young Men Taking HIV Meds May Be at Risk for Bone Loss
7. Taking the fate of stem cells in hand: RUB researchers generate immature nerve cells
8. Taking tissue regeneration beyond the state-of-the-art
9. Taking nothing at face value
10. Off-label drug use common, but patients may not know theyre taking them, Mayo finds
11. Antipsychotics Do Help Many With Schizophrenia, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
More Kids Taking Antipsychotics for ADHD: Study 
(Date:12/2/2016)... ... 2016 , ... Center for Autism and Related Disorders (CARD) Portland today announced ... disorder (ASD) and other developmental disabilities. The group, which is being launched with the ... the opportunity to share stories and advice, seek help, and continue their education on ...
(Date:12/2/2016)... ... 2016 , ... U.S. Surgeon General, Dr. Vivek Murthy, graces the cover of ... was inspired to practice medicine at an early age by his father, who was ... diagnoses and prescribing medicine,” he states. “It is about building relationships with people; relationships ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... two ostomy patients, standing as living proof that attitude and determination can combine ... and issues that spike around the holidays. This campaign will offer patients a ...
(Date:12/2/2016)... ... December 02, 2016 , ... More than half of American teens report losing ... report speaking with their child about sex related topics, less than 60 percent spoke ... proud to announce the launch of its second edition of the “Sexual Wellness” campaign, ...
(Date:12/2/2016)... ... 02, 2016 , ... CloudLIMS.com, a class-leading provider of Laboratory ... CloudLIMS Lite helps biobanks, clinical, research and testing laboratories keep track of their ... version is a faster and a more efficient product, allowing batch processing of ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... -- UCB is pleased to announce that 12 scientific abstracts have ... American Epilepsy Society (AES) Annual Meeting, which takes place ... USA. 1-12 Data being presented include ... ® (lacosamide) CV and BRIVIACT ® (brivaracetam) CV. ... state of the union of epilepsy care and antiepileptic drugs ...
(Date:12/2/2016)... -- Allergan plc (NYSE: AGN ), a leading ... announced Accelerated Share Repurchase (ASR) Program. Logo - ... , ... announced, the Company entered into a variable tenor ASR arrangement ... $10 billion of its ordinary shares. Approximately 40.5 million shares ...
(Date:11/30/2016)... , Nov 30, 2016 Research and ... Intracranial Pressure Monitoring Devices 2017 - MedCore" report to their offering. ... , , ... brain and the skull. In healthy individuals, it is circulated though the ... are cases where the amount of CSF surrounding the brain changes significantly. ...
Breaking Medicine Technology: