Navigation Links
More Genes Implicated in Type 2 Diabetes

By Amanda Gardner
HealthDay Reporter

SUNDAY, June 27 (HealthDay News) -- Scientists have located 12 new genes that seem to be linked with a predisposition for type 2 diabetes, bringing the total number of genetic locations implicated in the condition to 38.

At this point, the findings don't mean much for patients or doctors, although one day they may lead to better treatments.

"From here, to apply this clinically is going to be many more years," said Dr. Joel Zonszein, director of the Clinical Diabetes Center at Montefiore Medical Center in New York City.

"It is tough to pull clinical relevance out of [these types of studies], but this is laying the groundwork for what can come later," added Jacob L. McCauley, an assistant professor at the John P. Hussman Institute for Human Genomics at the University of Miami's Miller School of Medicine. "The size of this study is what's impressive. This provides a lot of power that in time these results will have medical relevance."

Also, Zonszein pointed out, these genes only relate to a predisposition for developing diabetes, not actually having or getting diabetes.

"Environmental factors are the other 50 percent of the story," he said.

And those environmental factors are well known. The most important is being overweight or obese.

According to the study authors, who publish their report in the June 27 online edition of Nature Genetics, the genes related to type 2 diabetes that are already known represent less than 10 percent of the total genetic picture of this disease.

"The majority of people with type 2 diabetes don't have a monogenetic [traceable to one gene] disease. These are only 4 to 5 percent," Zonszein said. "Most have a very complex polygenic disease."

And each of the genomic regions identified in this study lend only a small increase to the risk of diabetes.

These researchers, from Europe and North America, revisited data from previously conducted genome-wide association studies involving more than 8,000 individuals with type 2 diabetes and almost 40,000 healthy controls. All participants were of European descent.

They then added genetic data from another 34,000 people with diabetes and close to 60,000 controls.

The genes they found were associated with well-known biological processes of diabetes, namely beta-cell function (these are the pancreatic cells that produce insulin) and insulin performance, as well as cell-cycle regulation.

An unexpected finding was that one of the genes resides on the X chromosome. "That's important because it may indicate maternal inheritance," Zonszein explained.

"X chromosome association has been rare in most complex diseases, and this is the first one identified for type 2 diabetes," McCauley explained.

Also interesting is the fact that seven of the regions are known to be involved in other diseases or human characteristics including height, certain cardiovascular risk factors, and skin and prostate cancer.

"There are independent associated signals in what we would consider to be unrelated diseases or unrelated phenotypes," McCauley stated. "This further points out that biology is complex. Genes do a lot of things. They're involved with a lot of networks."

More information

The American Diabetes Association has more on type 2 diabetes.

SOURCES: Joel Zonszein, M.D., director, Clinical Diabetes Center, Montefiore Medical Center, New York City; Jacob L. McCauley, Ph.D., assistant professor, John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine; June 27, 2010, Nature Genetics

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scientists ID a protein that splices and dices genes
2. Genes May Influence Preterm Births
3. New Research Shows Genes of Pregnant Women and Their Fetuses Can Increase the Risk of Preterm Labor
4. Genes of pregnant women and their fetuses can increase the risk of preterm labor
5. NIH scientists identify maternal and fetal genes that increase preterm birth risk
6. Very Obese People May Be Missing Genes
7. Scientists map out regulatory regions of genome, hot spots for diabetes genes
8. Mutating Genes May Lead to Premature Births
9. ThermoGenesis Corp. Names Healthcare Industry Executive Craig Moore to Board of Directors
10. Genes, Diet Offer New Clues to Parkinsons Disease
11. Discovery Links Genes to Pancreatic Cancer
Post Your Comments:
Related Image:
More Genes Implicated in Type 2 Diabetes
(Date:6/24/2016)... , ... June 24, 2016 , ... Comfort Keepers® of ... Cancer Society and the Road To Recovery® program to drive cancer patients to and ... other adults to ensure the highest quality of life and ongoing independence. Getting ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing ... which patients and their families pay tribute to a genetic counselor by nominating him ... Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute ... Dr. Barry M. Weintraub as a prominent plastic surgeon and the network’s newest ... world, and the most handsome men, look naturally attractive. Plastic surgery should be ...
(Date:6/24/2016)... ... 24, 2016 , ... Strategic Capital Partners, LLC (SCP) in ... investment capital for emerging technology companies. SCP has delivered investment events and ... more than a million dollars of capital investment for five companies. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) sponsors ... on June 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, ... to helping service members that have been wounded in battle and their families. Venture ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has ... Global Analysis (United States, China, Japan, Brazil, United Kingdom, ... their offering. Surgical ... business planners, provides surgical procedure volume data in a ... an in-depth analysis of growth drivers and inhibitors, including ...
(Date:6/23/2016)... -- The Biotechnology industry might still be ... opportunities to investors. assesses the recent performances of ... XON ), Vertex Pharmaceuticals Inc. (NASDAQ: ... ), and Regeneron Pharmaceuticals Inc. (NASDAQ: REGN ... complimentary trade alerts at: ...
(Date:6/23/2016)... , June 23, 2016 Leading BioSciences ... address medical conditions resulting from a breakdown of ... appointed Greg Doyle as chief executive ... BioSciences, executive management team and board of directors, ... financial officer. He will provide continued leadership and ...
Breaking Medicine Technology: