Navigation Links
More Gene Variants Linked to Heart Trouble
Date:11/8/2012

THURSDAY, Nov. 8 (HealthDay News) -- Specific DNA variations explain more than 10 percent of the inherited genetic risk for developing heart disease, a new study suggests.

Researchers discovered 20 previously unidentified genetic variations in more than 63,000 people with coronary artery disease, which causes more deaths worldwide than any other disease.

These variations were uncommon in a control group of more than 130,000 people without heart disease.

The newly identified mutations bring to 47 the total number of genetic variations that have so far been linked to an increased risk for developing heart disease, according to study co-leader Panos Deloukas, head of the Genetics of Complex Traits in Humans research group at the Wellcome Trust Sanger Institute, in Cambridge, England.

One previous study estimated that 30 percent to 60 percent of heart disease cases might be attributable to genetic risk factors. This new study increases the number of genes likely involved in coronary artery disease.

The study was to be presented Thursday at the American Society of Human Genetics annual meeting in San Francisco.

"We no longer assume that coronary heart disease is triggered by just a handful of genes, each with a strong effect on a person's risk for the disease," Deloukas said in a society news release. "Our research supports the current assumption that heart disease risk is determined by a large group of genes, each with a modest effect on risk."

Deloukas said pinpointing the genetic variations involved in coronary artery disease may lead to improved treatments, and noted that many of the newly identified variations are in genes involved in the body's metabolism of fats as well as in inflammation.

The findings highlight the roles of high cholesterol levels and inflammation in coronary artery disease, Deloukas said.

Research presented at medical meetings should be viewed as preliminary until published in a peer-reviewed journal.

More information

The American Academy of Family Physicians has more about coronary artery disease.

-- Robert Preidt

SOURCE: American Society of Human Genetics, news release, Nov. 8, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Bigger human genome pool uncovers rarer variants
2. New gene variants raise risk of neuroblastoma, influence tumor progression
3. Genetic variants, tobacco exposure and lung cancer risk
4. High-Carb Diet Linked to Colon Cancer Recurrence in Study
5. Higher dietary glycemic load linked to worse colon cancer survival
6. Inflammation marker linked to increased risk for death from cancer in Korean men
7. Gene Linked to Alzheimers May Lose Power With Age
8. Acupuncture Might Ease Fatigue Linked to Breast Cancer
9. Lupus May Be Linked to Serious Pregnancy Complication
10. Stem Cell Therapy Reversed Chemo-Linked Infertility in Male Monkeys
11. Multiple C-Sections Linked to Raised Complication Risks: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
More Gene Variants Linked to Heart Trouble
(Date:5/24/2016)... ... May 24, 2016 , ... ... anticipated, web-based software module. The cutting-edge feature provides end users with an ... Izenda’s self-service business intelligence solution and its analytics engine. , This ...
(Date:5/24/2016)... ... May 24, 2016 , ... Celebration is in the Air, ... its 5th Annual Photo Contest. The label contest is underway, and hundreds of ... include a GoPro Hero4, a 40-inch high-definition flat-screen television, an Apple iPad Air ...
(Date:5/23/2016)... ... 23, 2016 , ... On Sunday, May 15, Rockynol Retirement ... assisted living center. After 18 months of construction, the new state-of-the-art structure was ... provides the latest in assisted living amenities and services, offering six different studio ...
(Date:5/23/2016)... ... ... Edward D. Buckingham, M.D . is excited announce that he has been ... out by the National Consumer Advisory Board to honor excellence in medicine. Only doctors ... award. , The National Consumer Advisory Board (NCAB) is a private organization created to ...
(Date:5/23/2016)... Angeles, CA (PRWEB) , ... May 23, 2016 , ... ... surgeons have noted that, less than 1% of United Kingdom residents who could benefit ... UK’s National Health Service (NHS) increases the number of bariatric procedures it offers to ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 2016 Een app die artsen ... collectief patiënten kunnen behandelen, hun kennis kunnen delen en ... de nieuwe en revolutionaire MDLinking App, ontwikkeld door een ... dr. Hans Flu en oncologisch chirurg dr. Gijs ... is, wordt op dinsdag 24 mei officieel gepresenteerd op ...
(Date:5/23/2016)... 2016 Transparency Market Research has ... Insufficiency Market - Global Industry Analysis, Size, Share, Growth, ... the report, the exocrine pancreatic insufficiency market is anticipated ... to 2023 to reach US$2.85 Bn by 2023. ... by the deficiency of the exocrine pancreatic enzymes, causing ...
(Date:5/23/2016)... May 23, 2016 Non-invasive diagnostic ... of multiple diseases; ,Technology to be presented at Yissum’s ... Yissum Research Development Company of the Hebrew University of ... research agreement with Aurum Ventures MKI, the technology investment arm ... a new diagnostic approach for early detection of multiple ...
Breaking Medicine Technology: