Navigation Links
More Gene Variants Linked to Heart Trouble
Date:11/8/2012

THURSDAY, Nov. 8 (HealthDay News) -- Specific DNA variations explain more than 10 percent of the inherited genetic risk for developing heart disease, a new study suggests.

Researchers discovered 20 previously unidentified genetic variations in more than 63,000 people with coronary artery disease, which causes more deaths worldwide than any other disease.

These variations were uncommon in a control group of more than 130,000 people without heart disease.

The newly identified mutations bring to 47 the total number of genetic variations that have so far been linked to an increased risk for developing heart disease, according to study co-leader Panos Deloukas, head of the Genetics of Complex Traits in Humans research group at the Wellcome Trust Sanger Institute, in Cambridge, England.

One previous study estimated that 30 percent to 60 percent of heart disease cases might be attributable to genetic risk factors. This new study increases the number of genes likely involved in coronary artery disease.

The study was to be presented Thursday at the American Society of Human Genetics annual meeting in San Francisco.

"We no longer assume that coronary heart disease is triggered by just a handful of genes, each with a strong effect on a person's risk for the disease," Deloukas said in a society news release. "Our research supports the current assumption that heart disease risk is determined by a large group of genes, each with a modest effect on risk."

Deloukas said pinpointing the genetic variations involved in coronary artery disease may lead to improved treatments, and noted that many of the newly identified variations are in genes involved in the body's metabolism of fats as well as in inflammation.

The findings highlight the roles of high cholesterol levels and inflammation in coronary artery disease, Deloukas said.

Research presented at medical meetings should be viewed as preliminary until published in a peer-reviewed journal.

More information

The American Academy of Family Physicians has more about coronary artery disease.

-- Robert Preidt

SOURCE: American Society of Human Genetics, news release, Nov. 8, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Bigger human genome pool uncovers rarer variants
2. New gene variants raise risk of neuroblastoma, influence tumor progression
3. Genetic variants, tobacco exposure and lung cancer risk
4. High-Carb Diet Linked to Colon Cancer Recurrence in Study
5. Higher dietary glycemic load linked to worse colon cancer survival
6. Inflammation marker linked to increased risk for death from cancer in Korean men
7. Gene Linked to Alzheimers May Lose Power With Age
8. Acupuncture Might Ease Fatigue Linked to Breast Cancer
9. Lupus May Be Linked to Serious Pregnancy Complication
10. Stem Cell Therapy Reversed Chemo-Linked Infertility in Male Monkeys
11. Multiple C-Sections Linked to Raised Complication Risks: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
More Gene Variants Linked to Heart Trouble
(Date:6/27/2016)... , ... June 27, 2016 , ... TopConsumerReviews.com recently awarded ... Eyeglasses . , Millions of individuals in the United States and Canada wear ... a way to both correct vision and make a fashion statement. Even celebrities use ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media ... give their videos a whole new perspective by using the title layers in ... Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 VolitionRx ... of Dr. Edward Futcher to the ... effective June 23, 2016.Dr. Futcher was also appointed ... Governance Committees.  As a non-executive member of the ... and strategic counsel to VolitionRx in connection with ...
(Date:6/23/2016)... 2016  MedSource announced today that it has ... solution of choice.  This latest decision demonstrates MedSource,s ... their clients by offering a state-of-the-art electronic data ... nowEDC as the EDC platform of choice in ... "nowEDC has long been a preferred EDC platform ...
(Date:6/23/2016)... June 23, 2016 Any dentist who has made ... the current process. Many of them do not even offer ... difficulties and high laboratory costs involved. And those who ARE ... at such a high cost that the majority of today,s ... Dr. Parsa Zadeh , founder of Dental Evolutions Inc. ...
Breaking Medicine Technology: