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More Focused Radiation Treatment May Work Better Against Brain Tumors
Date:1/11/2013

FRIDAY, Jan. 11 (HealthDay News) -- Treating aggressive brain tumors called glioblastomas with smaller, more focused areas of radiation does not increase the likelihood of tumor recurrence, a new study finds.

Restricting the radiotherapy to a smaller zone also spares the rest of the brain and preserves patients' brain function, the researchers note.

One outside expert explained that for many years, radiation treatment was spread over a larger area of the brain.

"Glioblastoma multiforme is one of the most deadly brain cancers despite aggressive treatment with surgery, radiation therapy and chemotherapy," said Dr. Louis Cornacchia, director of neurosurgery at Brookdale University Hospital and Medical Center, New York City. "For this reason, doctors who give radiation therapy have tended to treat the tumor plus a large margin (10 to 20 millimeters or more) outside the tumor on the theory that more radiation might improve outcomes."

However, "the down side is that the more brain that gets irradiated, the higher the risk of complications like cognitive [mental] dysfunction and radiation necrosis [tissue death]," Cornacchia said.

But the new study suggests that focusing radiation on a narrower area might have its advantages.

"We are the first to show definitively that people with smaller margins [areas of treatment] don't do any worse than those with larger margins," the study's lead investigator, Dr. Michael Chan, assistant professor of radiation oncology at Wake Forest Baptist Medical Center, said in a university news release.

"For patients with glioblastoma, we now know we can safely and effectively treat them with smaller radiation fields to spare the rest of their normal brain. That's important because it lessens the symptoms from radiation toxicity like tiredness and nausea."

For the study, published recently online in the American Journal of Clinical Oncology, researchers exam
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