Navigation Links
More Evidence That Statins Cut Stroke Risk
Date:1/14/2010

Benefit linked to cholesterol-lowering effect, study suggests

THURSDAY, Jan. 14 (HealthDay News) -- One of the largest analyses of the effect of statin drug therapy on the risk of stroke confirms the benefits of these widely used drugs.

Much of the benefit from statins such as Crestor, Lipitor and Zocor appears tied to the drugs' lowering of blood levels of "bad" LDL cholesterol, the researchers found.

Data from clinical trials including almost 267,000 participants showed an overall 12 percent reduction in stroke incidence among those taking statins, with each 1 percent reduction in total cholesterol predicting a 0.8 percent relative risk reduction of stroke.

The report, published in the Jan. 19 issue of the Journal of the American College of Cardiology, was led by physicians at G. d'Annunzio University in Chieti, Italy.

"This is consistent with prior studies and reinforces the benefit of statin therapy in preventing stroke in selected populations of patients," said Dr. Larry B. Goldstein, director of the Stroke Center at Duke University.

But the report contains hints that the reduction of stroke risk is not entirely explained by the cholesterol-lowering effect of statins, added Dr. Brendan M. Everett, an instructor in medicine at Harvard Medical School and attending cardiologist at Brigham and Women's Hospital. The JUPITER study, which he helped conduct, found a benefit for people with high levels of C-reactive protein, a marker of inflammation.

"There are many possible explanations for the reduction in stroke risk observed in actively treated patients, and one of those is a reduction of inflammation with statin therapy," Everett said. "In JUPITER, we observed a 48 percent reduction in total stroke and 51 percent reduction in ischemic stroke among patients with a normal LDL cholesterol at baseline."

An ischemic stroke, the most common form, occurs when a blood clot blocks a brain artery.

"We took people with normal cholesterol levels and saw a reduction in stroke similar to that in trials that selected people with higher levels of cholesterol," Everett said. "That suggests to me there's something else going on there."

That's possible, Goldstein said. "In clinical trials you measure LDL cholesterol, but many other things are going on at the same time," he said. "Still, the amount of benefit is directly related to the amount of cholesterol lowering."

While the JUPITER researchers focused on inflammation, "they still reduced LDL cholesterol levels significantly," Goldstein said.

There was no debate about the value of statin therapy in reducing other cardiovascular risks in people with high LDL levels. The Italian analysis found more benefits from statins than from other cholesterol-lowering regimens.

"Statins really ought to be our first choice for cholesterol reduction," Everett said. "That is true for heart disease and true for stroke. We showed that even patients with normal cholesterol levels may benefit from statins."

"The most gratifying thing reported by this meta-analysis is that statins among all lipid-lowering therapies appear to be the most effective," said Dr. Robert D. Brown, chairman of neurology at the Mayo Clinic in Minnesota. "The use of statin therapy is particularly important among people who have had a stroke. They are being used more aggressively in people who have had a stroke in an attempt to prevent another."

At least one trial has shown a significant reduction in second strokes among people taking statins, Brown noted.

More information

There's more on statins at the American Heart Association.



SOURCES: Larry B. Goldstein, M.D., director, Duke Stroke Center, Durham, N.C.; Brendan M. Everett, M.D., instructor, medicine, Harvard Medical School, and attending cardiologist, Brigham and Women's Hospital, Boston; Robert D. Brown, M.D., chairman, neurology, Mayo Clinic, Rochester, Minn; Jan. 11, 2010, Journal of the American College of Cardiology


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Jefferson researchers uncover new evidence of prolactins possible role in breast cancer
2. No strong evidence linking amateur boxing with long-term brain injury
3. AHRQ Announces Next Phase of Its Evidence-Based Practice Center Program
4. Vanderbilt Medical Center chosen as Evidence-based Practice Center
5. Little Evidence Silicone Breast Implants Harm Health
6. Consumers Should Demand Evidence, Not Guesswork, On Meat-Cancer Links
7. U of M study: Medicare lacks tools, incentives to enforce evidence-based coverage policies
8. New Study Provides Scientific Evidence That DermaLastyl Face Cream Reduces Wrinkles
9. Scientific evidence of the significant anti-cancer effect of milk thistle
10. Defining the Value of Medicine in an Evidence-Based Healthcare Marketplace
11. UC Davis researchers find evidence of mature heart cell potential in embryonic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... 2016 , ... When it came time to blow out his candles on his 14th birthday, ... Pediatric Heart Transplant team at Joe DiMaggio Children’s Hospital surprised his family with a ... heart transplant recipient. , “He was playing at home, when we got the phone ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... services from offices located in South Lyon, Dewitt, Williamston, East Lansing, Ann Arbor, ... coach who needs treatment for a brain tumor. , Jason Bauer and his ...
(Date:12/7/2016)... ... 07, 2016 , ... Augustine Insurance Agency, a locally owned ... owners in the greater Dallas metropolitan area, is announcing a charity event that ... Established in 2009 by active police professionals in the Dallas region, the Dallas ...
(Date:12/7/2016)... ... December 07, 2016 , ... AlignLife clinics nationwide are giving back to ... fortunate enough to receive bountiful gifts wrapped tightly under a Christmas Tree. AlignLife ... children of the world. , In exchange for generous donations, customers will receive a ...
(Date:12/7/2016)... ... OCTOBER XX, 2016 (PRWEB) (PRWEB) December 07, 2016 , ... ... “Canine Filamentous Dermatitis Associated with Borrelia Infection” reveals that a condition ... in the prestigious Journal of Veterinary Science & Medical Diagnosis. , Morgellons disease ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... DIEGO , Dec. 6, 2016 /PRNewswire/ ... on the development of Conditionally Active Biologic ... and Beijing Sinobioway Group Company, Limited (Sinobioway) ... for development.  The specific program candidates and ... March 2015, BioAtla and Sinobioway entered into ...
(Date:12/6/2016)... , Dec. 6, 2016 In this age ... to be hopeful.  A special kind of sunglasses, from ... anxious life. Photo - http://photos.prnewswire.com/prnh/20161205/445444 ... Robert Buck, the psychotherapist who developed and patented the ... to overcoming anxiety and worry.  "Anxiety doesn,t have ...
(Date:12/5/2016)... Dec. 5, 2016  Zimmer Biomet Holdings, Inc. (NYSE ... pursuant to its previously-announced cash tender offers (the ... table below (collectively, the "Notes"), approximately $2.6 billion in ... and not validly withdrawn on or prior to ... time, today, December 5, 2016 (the "Early Tender ...
Breaking Medicine Technology: