Navigation Links
More Doubt on Link Between a Blood Chemical and Heart Disease
Date:2/21/2012

TUESDAY, Feb. 21 (HealthDay News) -- Having high levels of the amino acid homocysteine won't raise your risk of developing heart disease, a new analysis indicates.

The findings appear to close the door on the potential benefit of lowering homocysteine levels with folic acid supplements, according to report author Robert Clarke, of the University of Oxford in the United Kingdom, and his colleagues.

The researchers also said previous studies that suggested high levels of homocysteine might be a modifiable risk factor for heart disease were plagued by publication bias and methodological problems.

Clarke and his team analyzed data on nearly 50,000 heart disease patients and 68,000 healthy people, culled from 86 published studies and 19 unpublished studies. There was no increased risk of heart disease in people who had an MTHFR gene variant that is associated with 20 percent higher blood homocysteine levels.

The MTHFR gene plays a role in the production of methylene tetrahydrofolate reductase, which uses folate to break down and remove homocysteine.

The study appears in this week's issue of the journal PLoS Medicine.

"The discrepancy between the overall results in the unpublished and the published datasets is too extreme to be plausibly dismissed as a chance finding," the researchers wrote. "Some studies, particularly if small, might have been prioritized for publication by investigators, referees or editors according to the positivity of their results and some may have been liable to other methodological problems that bias the average of all results. To avoid such biases, we chiefly emphasize the new results from the previously unpublished datasets."

"The magnitude of the effect of publication bias is substantial and, in addition to distorting the association of MTHFR with [coronary heart disease] in published studies, publication bias may also help explain the discrepant findings recently reported for MTHFR and stroke," they concluded.

More information

The U.S. National Heart Lung and Blood Institute has more about coronary heart disease.

-- Robert Preidt

SOURCE: PLoS Medicine, news release, Feb. 21, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Doubt Cast on Use of Genetic Test Before Plavix
2. Requests for Alzheimers disease research grants up by 33 percent, as federal funding in doubt
3. Study Casts Doubt on Hot Dogs Link to Colon Cancer
4. New Report Casts More Doubt on Virus Link to Chronic Fatigue Syndrome
5. Intensive care nurses have doubts about method for establishing brain death
6. Lifesaving antibiotics face doubtful future
7. Study Casts Doubt on Hospice Admission Criteria for Patients With Dementia
8. The balancing act between protection and inflammation in MS
9. UCLA scientists report link between traumatic brain injury, post-traumatic stress disorder
10. Molecular profiling reveals differences between primary and recurrent ovarian cancers
11. ROCK off: Study establishes molecular link between genetic defect and heart malformation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
More Doubt on Link Between a Blood Chemical and Heart Disease
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... Those ... deal with these feelings, many turn to unhealthy avenues, such as drug or alcohol ... of Marne, Michigan, has released tools for healthy coping following a traumatic event. , ...
(Date:6/24/2016)... ... 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 ... by their peers for this recognition are considered among the top 2 percent of ... honors as members of this year’s Legal Elite Hall of Fame: Miami Shareholders ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their ... Award, an essay contest in which patients and their families pay tribute to a ... the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... actively feeding the Frederick area economy by obtaining investment capital for emerging technology ... past 2½ years that have already resulted in more than a million dollars ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Collagen Matrix, ... design, development and manufacturing of collagen and mineral ... announced today that Bill Messer has ... Marketing to further leverage the growing portfolio of ... devices. Bill joins the Collagen Matrix ...
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
(Date:6/24/2016)... , June 24, 2016 Research and ... Market for Companion Diagnostic Tests" report to their offering. ... for Companion Diagnostics The World Market for ... personalized medicine diagnostics. Market analysis in the report includes the ... Market (In Vitro Diagnostic Kits) by Region (N. America, EU, ...
Breaking Medicine Technology: