Navigation Links
More Dialysis Not Better in Acute Kidney Injury

Intensive therapy did not improve recovery or survival, researchers say.

TUESDAY, May 20 (HealthDay News) -- Intensive kidney dialysis for patients with acute kidney injury does not reduce death, improve kidney function, or reduce the rate of organ failure, a new study finds.

Acute kidney injury is a complication often seen in critically ill patients. Approximately 2 percent to 7 percent of hospitalized patients, and 35 percent of critically ill patients, will suffer from acute kidney injury. For patients with acute kidney injury, the death rate is approximately 50 percent to 80 percent.

"In acute kidney injury, there is no specific treatment to reverse kidney function," said lead researcher Dr. Paul M. Palevsky, a professor of medicine at the University of Pittsburgh. "The treatment is predominantly supportive."

The common teaching has been that in people who survived the illness, most will recover kidney function, Palevsky said. Previous studies have suggested that more dialysis improved outcomes. "So, we did the study to see if that was the case," Palevsky explained.

"Increasing the dose of dialysis beyond what is considered normal did not improve outcomes," Palevsky said. "There was no improvement in survival, no improvement in recovery of renal function, and no improvement in the course of non-renal organ failure. So, more was not better."

The report was released early, in the May 20 online edition of the New England Journal of Medicine, to coincide with a presentation at the American Thoracic Society's International Conference, in Toronto.

In the study, Palevsky's team randomly assigned 1,124 patients with acute kidney injury to receive intensive or less intensive dialysis.

Patients who received intensive renal therapy had dialysis six times a week, while patients who received less intensive renal therapy, underwent dialysis three times a week.

The researchers found that the rate of death, after two months, was 53.6 percent among patients receiving intensive renal therapy and 51.5 percent among patients receiving less intensive therapy.

Moreover, there was no difference between the groups in the length of time renal replacement therapy was given, the recovery of kidney function or failure of other organs, the researchers found.

"The evidence suggests that doing it well, but not necessarily doing more of it, is what is best for patients," Palevsky said.

One expert said that the results of the study will change how patients with acute renal injury are treated.

"This is an important study that will change our practice," said Dr. Ajay K. Singh, from the Renal Division at Brigham and Women's Hospital and an associate professor of medicine at Harvard Medical School in Boston.

At Brigham, for example, Singh said that based on previously published studies, they were treating patients more intensively. "Based on this study, we will go back to adopting the less-intensive approach," he said

"However, it is disappointing that we are unable to identify a therapeutic strategy that improves the survival of our patients with acute kidney injury," Singh said. "This study should further underscore the importance of developing novel strategies to improve outcomes in these patients."

More information

For more about acute kidney failure, visit the U.S. National Library of Medicine.

SOURCES: Paul M. Palevsky, M.D., professor, medicine, University of Pittsburgh; Ajay K. Singh, M.B., Renal Division, Brigham and Women's Hospital, and associate professor, medicine, Harvard Medical School, Boston; May 20, 2008, New England Journal of Medicine, online

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Blood-Thinner No Help for Dialysis Treatment
2. Kidney Community Gathers on Capitol Hill to Ask Congress to Support Legislation for Increased Kidney Care Education, Updates for Kidney Dialysis Benefit
3. Dialysis Corporation of America Announces the Development of a New Facility in Pennsylvania
4. Dialysis Corporation of America Earnings Call Reminder
5. Dialysis Corporation of America Reports Fourth Quarter and Year Ended December 31, 2007 Results
6. Dialysis Corporation of America Announces Fiscal Year 2007 Earnings Release Date
7. Dialysis Corporation of America Announces its Newest Center Opening in South Carolina
8. Standard test for blood sugar control not accurate in diabetic dialysis patients
9. Dialysis Corporation of America Announces Opening of New Dialysis Center in Ohio
10. Nations Leading Dialysis Provider - DaVita - Partners with eDiets(R) to Launch One-of-a-Kind Diet Helper Online Nutrition and Meal Planning Tool for Late-Stage Kidney Disease Patients and Caregivers
11. 16-Year-Old Ecuadorian Boy in Dire Need of Dialysis Treatments Thanks One of Nations Leading Providers for Saving His Life
Post Your Comments:
Related Image:
More Dialysis Not Better in Acute Kidney Injury
(Date:10/13/2017)... ... October 13, 2017 , ... ... ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice ... of cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , ... mock evacuation of the facility as part of a disaster drill on October 3rd. ... EMS and Shelton City Emergency Manager, as well as the Connecticut Long Term ...
(Date:10/13/2017)... ... 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud ... and unique items from across the nation, this holiday-themed event will raise funds and ... the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed ... geared towards children of all ages; it is a non-competitive, non-timed event, which is ...
(Date:10/13/2017)... ... 13, 2017 , ... Talented host, actor Rob Lowe, is ... a new episode of "Success Files," which is an award-winning educational program broadcasted ... each subject in-depth with passion and integrity. , Sciatica occurs when the sciatic ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... , Oct. 6, 2017   Provista, a ... than $100 billion in purchasing power, today announced a ... information. The Newsroom is the online home ... trends, infographics, expert bios, news releases, slideshows and events. ... to a wealth of resources at their fingertips, viewers ...
(Date:10/2/2017)... 2017 Diplomat Pharmacy, Inc. (NYSE: ... Consulting, LLC , and named its founder as Diplomat,s ... Tennessee , will operate under Diplomat ... service offerings for health care partners to include IT ... "In an interoperable world, technology delivers comprehensive ...
(Date:9/28/2017)... -- Hill-Rom Holdings, Inc. (NYSE: HRC), will host its ... on Friday, November 3, 2017, beginning at 7:00 a.m. ... 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... and guidance for 2018, Hill-Rom executives will also highlight ... and long-range financial outlook through 2020. ...
Breaking Medicine Technology: