Navigation Links
More Dialysis Not Better in Acute Kidney Injury
Date:5/20/2008

Intensive therapy did not improve recovery or survival, researchers say.

TUESDAY, May 20 (HealthDay News) -- Intensive kidney dialysis for patients with acute kidney injury does not reduce death, improve kidney function, or reduce the rate of organ failure, a new study finds.

Acute kidney injury is a complication often seen in critically ill patients. Approximately 2 percent to 7 percent of hospitalized patients, and 35 percent of critically ill patients, will suffer from acute kidney injury. For patients with acute kidney injury, the death rate is approximately 50 percent to 80 percent.

"In acute kidney injury, there is no specific treatment to reverse kidney function," said lead researcher Dr. Paul M. Palevsky, a professor of medicine at the University of Pittsburgh. "The treatment is predominantly supportive."

The common teaching has been that in people who survived the illness, most will recover kidney function, Palevsky said. Previous studies have suggested that more dialysis improved outcomes. "So, we did the study to see if that was the case," Palevsky explained.

"Increasing the dose of dialysis beyond what is considered normal did not improve outcomes," Palevsky said. "There was no improvement in survival, no improvement in recovery of renal function, and no improvement in the course of non-renal organ failure. So, more was not better."

The report was released early, in the May 20 online edition of the New England Journal of Medicine, to coincide with a presentation at the American Thoracic Society's International Conference, in Toronto.

In the study, Palevsky's team randomly assigned 1,124 patients with acute kidney injury to receive intensive or less intensive dialysis.

Patients who received intensive renal therapy had dialysis six times a week, while patients who received less intensive renal therapy, underwent dialysis three times a week.

The researchers found that the rate of death, after two months, was 53.6 percent among patients receiving intensive renal therapy and 51.5 percent among patients receiving less intensive therapy.

Moreover, there was no difference between the groups in the length of time renal replacement therapy was given, the recovery of kidney function or failure of other organs, the researchers found.

"The evidence suggests that doing it well, but not necessarily doing more of it, is what is best for patients," Palevsky said.

One expert said that the results of the study will change how patients with acute renal injury are treated.

"This is an important study that will change our practice," said Dr. Ajay K. Singh, from the Renal Division at Brigham and Women's Hospital and an associate professor of medicine at Harvard Medical School in Boston.

At Brigham, for example, Singh said that based on previously published studies, they were treating patients more intensively. "Based on this study, we will go back to adopting the less-intensive approach," he said

"However, it is disappointing that we are unable to identify a therapeutic strategy that improves the survival of our patients with acute kidney injury," Singh said. "This study should further underscore the importance of developing novel strategies to improve outcomes in these patients."

More information

For more about acute kidney failure, visit the U.S. National Library of Medicine.



SOURCES: Paul M. Palevsky, M.D., professor, medicine, University of Pittsburgh; Ajay K. Singh, M.B., Renal Division, Brigham and Women's Hospital, and associate professor, medicine, Harvard Medical School, Boston; May 20, 2008, New England Journal of Medicine, online


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Blood-Thinner No Help for Dialysis Treatment
2. Kidney Community Gathers on Capitol Hill to Ask Congress to Support Legislation for Increased Kidney Care Education, Updates for Kidney Dialysis Benefit
3. Dialysis Corporation of America Announces the Development of a New Facility in Pennsylvania
4. Dialysis Corporation of America Earnings Call Reminder
5. Dialysis Corporation of America Reports Fourth Quarter and Year Ended December 31, 2007 Results
6. Dialysis Corporation of America Announces Fiscal Year 2007 Earnings Release Date
7. Dialysis Corporation of America Announces its Newest Center Opening in South Carolina
8. Standard test for blood sugar control not accurate in diabetic dialysis patients
9. Dialysis Corporation of America Announces Opening of New Dialysis Center in Ohio
10. Nations Leading Dialysis Provider - DaVita - Partners with eDiets(R) to Launch One-of-a-Kind Diet Helper Online Nutrition and Meal Planning Tool for Late-Stage Kidney Disease Patients and Caregivers
11. 16-Year-Old Ecuadorian Boy in Dire Need of Dialysis Treatments Thanks One of Nations Leading Providers for Saving His Life
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
More Dialysis Not Better in Acute Kidney Injury
(Date:6/27/2016)... California (PRWEB) , ... June 27, 2016 , ... "FCPX ... fully customizable inside of Final Cut Pro X," said Christina Austin - CEO of ... unique style. Final Cut Pro X users can now reveal the media ...
(Date:6/27/2016)... Park, KS (PRWEB) , ... June 27, 2016 , ... ... in retailers of Eyeglasses . , Millions of individuals in the United States ... eyeglasses have become a way to both correct vision and make a fashion statement. ...
(Date:6/26/2016)... North Carolina (PRWEB) , ... June 26, 2016 , ... ... release of a new product that was developed to enhance the health of felines. ... for centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica Scruggs ... for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs surgery, ... Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, MD, ...
(Date:6/25/2016)... ... 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned ... the David Geffen School of Medicine at UCLA. He trained in Internal Medicine at ... fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Global Blood Therapeutics, Inc. (GBT) (NASDAQ: ... novel therapeutics for the treatment of grievous blood-based ... closing of its previously announced underwritten public offering ... public offering price of $18.75 per share. All ... by GBT. GBT estimates net proceeds from the ...
(Date:6/24/2016)... Dublin ... of the " Global Markets for Spectroscopy Equipment" ... This report focuses on the global ... including its applications in various applications. The report deals ... three main industries: pharmaceutical and biotechnology, food and beverage, ...
(Date:6/24/2016)... 24, 2016 The Academy of Managed Care ... that would allow biopharmaceutical companies to more easily ... make formulary and coverage decisions, a move that addresses ... medicines. The recommendations address restrictions in the ... the drug label, a prohibition that hinders decision makers ...
Breaking Medicine Technology: