Navigation Links
More Cancer Tests Mean More False-Positive Results
Date:5/11/2009

Risk for incorrect but worrying findings rises 50 percent by the 14th test, study finds,,,,

MONDAY, May 11 (HealthDay News) -- The more cancer screening tests you undergo, the higher your risk of having at least one false-positive result, researchers say.

While that conclusion may seem like common sense, it's not something that patients or doctors often consider, suggest the authors of a study in the May/June issue of the Annals of Family Medicine.

False-positive results from routine cancer screening can cause undue worry and in some cases lead to unnecessary biopsies or treatments, experts note.

In the new study, "after 14 tests total, over half of the people in our study had a false-positive result. No test is perfect, and you would expect to see it go up over time, but how rapidly the risk went up was surprising," said the study's lead author, Dr. Jennifer Croswell, acting director of the office of medical applications of research at the U.S. National Institutes of Health in Bethesda, Md.

"It's important to know ahead of time the risk of false-positives," she said. "Screenings have to be thought of like any other medical intervention and it's important to have the discussion about the risks and the benefits."

Croswell and her colleagues reviewed data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, which included nearly 70,000 participants. The study volunteers were between the ages of 55 and 74, and were randomly selected to receive either normal care or more intensive screening.

Those in the normal-care group were offered screening through their own private physicians as usual. Those in the intervention group were offered a baseline chest X-ray along with a yearly follow-up for two years for non-smokers and three years for smokers to check for lung cancer; a baseline flexible sigmoidoscopy to check for colorectal cancer, along with a three- or five-year follow-up; annual tests for cancer antigen 125 (CA-125) and a transvaginal ultrasound yearly to check for ovarian cancer in women; and an annual digital rectal exam to check for prostate cancer in men, as well as a prostate-specific antigen test.

No information was included on mammography for women in either the intervention group or the usual care group.

For those who had 14 screening tests during the study period, the cumulative risk of having at least one false-positive was 60.4 percent for men and about 49 percent for women. The cumulative risk of having to undergo an invasive diagnostic procedure due to a false-positive test result was almost 29 percent for men and just over 22 percent for women.

Croswell said the researchers weren't sure why the false-positive rate was higher for men, but it likely had something to do with the tests that were studied.

"The fact is that screening tests aren't diagnostic," said Robert Smith, director of cancer screening for the American Cancer Society. "A certain risk of false positives and false negatives are to be expected. You can try to very aggressively reduce the false-positive rate, but then you also cut into cancer detection rates," he explained.

"Most people place a higher priority on finding cancer early than preventing false-positives. I think the public often understands that false-positives happen," said Smith. But, he added, "We really need to do a better job of explaining to adults that there is a plus side and a down side to screening. We need to do a better job of letting people know what to expect, and that screening tests aren't perfect."

In another study in the same issue of the journal, researchers at the University of Auckland, New Zealand, take a different look at medical errors, and focus on the types of errors that patients make. While the study didn't attempt to rank which medical errors patients are most likely to make, the researchers did try to identify the types of errors patients might make.

They found that patient errors could be classified into two broad categories: action or mental errors. Action errors are related to patient behavior and may include coming late to an appointment or not following directions when taking medications. Mental errors are when a patient has compromised thought processes, memory problems or knowledge deficits. Examples of mental errors include forgetting to take medications or a failure to understand the doctor's instructions. The authors suggest that future research should try to account for these errors and find ways for clinicians and patients to work together to reduce errors.

More information

The American Cancer Society's Web site lists which cancer screenings you need.



SOURCES: Jennifer M. Croswell, M.D., acting director, office of medical applications of research, U.S. National Institutes of Health, Bethesda, Md.; Robert Smith, Ph.D., director of cancer screening, American Cancer Society; May/June 2009 Annals of Family Medicine


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study finds iron levels not predictive of survival for form of blood cancer
2. Where You Live May Affect Your Cancer Diagnosis
3. HealthCentral.com Collaborates With BreastCancer.org, Providing Quality Awareness Sponsorships to #1 Breast Cancer Resource Online
4. Surgery improves survival for prostate cancer patients younger than 50
5. Over 3,000 Skin Cancer Patients Treated with the TOPEX System.............
6. Research Findings on Nine GlaxoSmithKline Cancer Compounds to be Presented at ASCO 2009
7. Conflicts of Interest Still Exist in Cancer Research
8. Review finds conflicts of interest in many cancer studies
9. City-dwellers have higher risk of late-stage cancer than rural residents
10. Budget Cuts for Free Cancer Screening Clinics in New York Could Put Patients' Lives at Risk, Says New York Medical Malpractice Lawyer
11. Make No Small Plans: M. D. Anderson Cancer Center Endeavors to Make Cancer History
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
More Cancer Tests Mean More False-Positive Results
(Date:12/2/2016)... ... December 02, 2016 , ... CloudLIMS.com, a class-leading ... LIMS, CloudLIMS Lite. CloudLIMS Lite helps biobanks, clinical, research and testing laboratories keep ... disposal. The new version is a faster and a more efficient product, allowing ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... diagnostic imaging systems and the first company to offer robotic imaging to ... at their tradeshow booth # 941 for the American Association of Equine Practitioners ...
(Date:12/2/2016)... ... December 02, 2016 , ... Rijuven Corp launches rejiva ( http://www.rejiva.com ... and night. No other wearable health technology on the market can deliver all that ... poeple more meaningful insights about their health than the usual heart rate and steps ...
(Date:12/2/2016)... ... 2016 , ... "Pro3rd Accents Volume 2 is a set of 30 accented ... with just a few clicks of the mouse," said Christina Austin - CEO of ... Choose from various styles with accented animations, rigid boxes, simplistic lines, and more. In ...
(Date:12/2/2016)... Miami, FL (PRWEB) , ... December 02, 2016 ... ... over 5,100 hot meals to needy individuals and families from eight different sites ... Florida on Thanksgiving Day. Over 1,000 volunteers worked very hard on Thanksgiving morning ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... Research and Markets has announced the addition of the ... to 2022" report to their offering. ... , , The global ultrasound ... is expected to grow at a CAGR of 5.5% during 2016-2022. Based ... during the forecast period, a CAGR of 8.8% in the global market. ...
(Date:12/2/2016)... Quantum Radiology,s Mobile Breast Center (QR MBC) brings cutting-edge ... at the workplace, thereby maximizing convenience and compliance.  QR ... and SunTrust Bank, and community health groups to provide ... "I think it,s a great service for ... a mammogram without taking a large amount of time ...
(Date:12/2/2016)... 2, 2016 In the first ever attempt ... those derived from C. sativa, the Hebrew University in ... Napoli Federico II , the Universita` del Piemonte Orientale ... critical, integrated and unified inventory of phytocannabinoids of different ... on the remarkable chemical and structural diversity of phytocannabinoids. ...
Breaking Medicine Technology: